{"id":98,"date":"2017-03-03T13:40:14","date_gmt":"2017-03-03T18:40:14","guid":{"rendered":"https:\/\/research.cbc.osu.edu\/bong.6\/?page_id=98"},"modified":"2023-05-31T13:56:02","modified_gmt":"2023-05-31T17:56:02","slug":"about","status":"publish","type":"page","link":"https:\/\/research.cbc.osu.edu\/bong.6\/","title":{"rendered":"About"},"content":{"rendered":"<p><em>General.\u00a0<\/em>Our research group uses organic synthesis and biochemistry to study fundamental and applied aspects of molecular recognition of non-canonical nucleic acid structures. Through synthesis and design, our group develops new functional polymer, peptide, lipid and nucleic acid assemblies to address problems in controlled chemical delivery and biosensing. Though each\u00a0research effort is grounded in\u00a0organic synthesis, these synthetic systems are interrogated using biophysical, biochemical and\u00a0cell culture methods.<\/p>\n<p><em>Systems.<\/em> Much of our current<img loading=\"lazy\" decoding=\"async\" class=\"alignright wp-image-148\" src=\"https:\/\/research.cbc.osu.edu\/bong.6\/wp-content\/uploads\/2017\/03\/TMT-300x197.jpg\" alt=\"\" width=\"206\" height=\"135\" srcset=\"https:\/\/research.cbc.osu.edu\/bong.6\/wp-content\/uploads\/2017\/03\/TMT-300x197.jpg 300w, https:\/\/research.cbc.osu.edu\/bong.6\/wp-content\/uploads\/2017\/03\/TMT-768x503.jpg 768w, https:\/\/research.cbc.osu.edu\/bong.6\/wp-content\/uploads\/2017\/03\/TMT.jpg 810w\" sizes=\"auto, (max-width: 206px) 100vw, 206px\" \/>\u00a0research centers<br \/>\non the use of an unnatural triazine heterocycle, melamine, as an artificial base triple with U\/U or T\/T. When displayed multivalently, the melamine base engages with two Watson-Crick faces of thymine\/uracil in DNA\/RNA, resulting in the formation of triple-stranded hybrid structures. Synthetic triplex hybridizing molecules that utilize melamine as a base triple are in a family of molecules we call &#8220;bPNA&#8221; to represent bifacial [Peptide\/Peptoid\/Polymer] nucleic acid, according to the backbone used for melamine display. We have studied bPNAs as allosteric\u00a0switches for aptamer binding and ribozyme catalysis, as well as packaging and targeting elements for siRNA delivery. Current research continues along these lines.<\/p>\n<p><strong>NEWS<\/strong><\/p>\n<p>Congratulations to Dr. Yufeng Liang on his paper in Nature Communications!<\/p>\n<p>Welcome to our summer 2023 rotation student, Alexis Young!<\/p>\n","protected":false},"excerpt":{"rendered":"<p>General.\u00a0Our research group uses organic synthesis and biochemistry to study fundamental and applied aspects of molecular recognition of non-canonical nucleic acid structures. Through synthesis and design, our group develops new functional polymer, peptide, lipid and nucleic acid assemblies to address problems in controlled chemical delivery and biosensing. Though each\u00a0research effort is grounded in\u00a0organic synthesis, these &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/research.cbc.osu.edu\/bong.6\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;About&#8221;<\/span><\/a><\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-98","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/research.cbc.osu.edu\/bong.6\/wp-json\/wp\/v2\/pages\/98","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/research.cbc.osu.edu\/bong.6\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/research.cbc.osu.edu\/bong.6\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/research.cbc.osu.edu\/bong.6\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/research.cbc.osu.edu\/bong.6\/wp-json\/wp\/v2\/comments?post=98"}],"version-history":[{"count":18,"href":"https:\/\/research.cbc.osu.edu\/bong.6\/wp-json\/wp\/v2\/pages\/98\/revisions"}],"predecessor-version":[{"id":225,"href":"https:\/\/research.cbc.osu.edu\/bong.6\/wp-json\/wp\/v2\/pages\/98\/revisions\/225"}],"wp:attachment":[{"href":"https:\/\/research.cbc.osu.edu\/bong.6\/wp-json\/wp\/v2\/media?parent=98"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}