{"id":898,"date":"2016-04-28T22:36:38","date_gmt":"2016-04-29T02:36:38","guid":{"rendered":"https:\/\/research.cbc.osu.edu\/foster.281\/?page_id=898"},"modified":"2022-03-29T16:38:00","modified_gmt":"2022-03-29T20:38:00","slug":"fosterlab-home","status":"publish","type":"page","link":"https:\/\/research.cbc.osu.edu\/foster.281\/","title":{"rendered":"FosterLab Home"},"content":{"rendered":"

Mark P. Foster, PhD\"(img)\"<\/a><\/h2>\n

Department of Chemistry and Biochemistry<\/a>
\nOhio State Biochemistry Program (OSBP)<\/a>
\nBiophysics Program<\/a>
\nCenter for RNA Biology<\/a>
\nCellular, Molecular, and Biochemical Sciences Program (CMBP)<\/a>
\nChemistry-Biology Interface Training Program (CBIP)<\/a>
\nThe Ohio State University<\/a>
\n496 West 12th Ave, Columbus, OH, 43210<\/p>\n

\n

Structure and Dynamics in Biological Regulation by Proteins, Nucleic Acids and their Ligands<\/h1>\n

Welcome to the Foster Lab. Our group uses nuclear magnetic resonance spectroscopy (NMR) and other biochemical and biophysical techniques to understand the structure and function of biological molecules, and decipher the ways they recognize and interact with each other. Our group and our collaborators tackle a range of fascinating questions that allow us to understand how genes are regulated (turned “on” or “off”), how enzymes catalyze chemical reactions, or how drug-like molecules bind and inhibit their cellular targets. Such insights are fundamental to understanding biology and for applying that knowledge to problems in medicine or biotechnology. Members of the lab receive both broad training in biochemistry, biophysics and structural biology, and highly focused training centered on their research project and the tools most critical to its advancement. With this combination of broad and deep research training, group members emerge with the scientific skills to pursue careers in a wide variety of settings, from academia to the private sector.<\/p>\n

Projects in the Foster Lab include interaction of retroviral integrases (HIV, MLV) with eukaryotic transcriptional machinery (LEDGF, Brd4), ligand-dependent binding of proteins to nucleic acids (TRAP, Loz1), enzyme dynamics (Cre recombinase, RNase P, ProXp-Ala), and RNA-mediated gene regulation (riboswitches). In partnership with our collaborators, we tackle fascinating research problems in a supportive, exciting and fast-paced learning environment. We invite you to visit our web pages and contact us if you have questions or are interested in collaborations, or to learn more about our science.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Mark P. Foster, PhD Department of Chemistry and Biochemistry Ohio State Biochemistry Program (OSBP) Biophysics Program Center for RNA Biology Cellular, Molecular, and Biochemical Sciences Program (CMBP) Chemistry-Biology Interface Training Program (CBIP) The Ohio State University 496 West 12th Ave,<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"jetpack_post_was_ever_published":false,"footnotes":""},"class_list":["post-898","page","type-page","status-publish","hentry"],"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/P7sxod-eu","jetpack-related-posts":[{"id":8,"url":"https:\/\/research.cbc.osu.edu\/foster.281\/members-2023\/","url_meta":{"origin":898,"position":0},"title":"Foster Lab Members","author":"Mark Foster","date":"August 8, 2013","format":false,"excerpt":"\u00a0 Mark P. Foster, PhD ProfessorDepartment of Chemistry and BiochemistryThe Ohio State University484 West 12th Ave, Columbus OH 43210EmailB.S.\u00a0University of Illinois, 1987Ph.D University of Utah, 1993Postdoctoral Fellow, The Scripps Research Institute, 1993-1997 \u00a0 \u00a0 Antonia Duran Ohio State Biochemistry Program, Email Describing the structural basis of protein-protein interactions provides valuable\u2026","rel":"","context":"Similar post","block_context":{"text":"Similar post","link":""},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/research.cbc.osu.edu\/foster.281\/wp-content\/uploads\/2023\/08\/image-20230727-193300-178586a0-1024x769.jpeg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/research.cbc.osu.edu\/foster.281\/wp-content\/uploads\/2023\/08\/image-20230727-193300-178586a0-1024x769.jpeg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/research.cbc.osu.edu\/foster.281\/wp-content\/uploads\/2023\/08\/image-20230727-193300-178586a0-1024x769.jpeg?resize=525%2C300&ssl=1 1.5x"},"classes":[]},{"id":1936,"url":"https:\/\/research.cbc.osu.edu\/foster.281\/members\/","url_meta":{"origin":898,"position":1},"title":"Current Lab Members","author":"Mark Foster","date":"January 12, 2025","format":false,"excerpt":"Foster Group members, August 2024. Megan, Robert, Matthew, Tyler, William, Jon, Antonia, Rodrigo, Haoyun, Joe, Mark. Missing: Caroline and Madelyn. \u00a0 Mark P. Foster, PhD ProfessorDepartment of Chemistry and BiochemistryThe Ohio State University484 West 12th Ave, Columbus OH 43210EmailB.S.\u00a0University of Illinois, 1987Ph.D University of Utah, 1993Postdoctoral Fellow, The Scripps Research\u2026","rel":"","context":"Similar post","block_context":{"text":"Similar post","link":""},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/research.cbc.osu.edu\/foster.281\/wp-content\/uploads\/2025\/01\/image-2.png?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/research.cbc.osu.edu\/foster.281\/wp-content\/uploads\/2025\/01\/image-2.png?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/research.cbc.osu.edu\/foster.281\/wp-content\/uploads\/2025\/01\/image-2.png?resize=525%2C300&ssl=1 1.5x"},"classes":[]},{"id":26,"url":"https:\/\/research.cbc.osu.edu\/foster.281\/members-2023\/alumni\/","url_meta":{"origin":898,"position":2},"title":"Alumni","author":"Eric Danhart","date":"August 8, 2013","format":false,"excerpt":"\u00a0 Joseph Hazel PhD, Chemistry, 2025. Email. First position: \u00a0 \u00a0 Antonia Duran B.S. Biochemistry, 2017, University of New Mexico First position: Scientist, Battelle Memorial Institute \u00a0 \u00a0 Haoyun Yang PhD, Chemistry, 2024. Email First position: Postdoc, Houston Methodist Research Institute \u00a0 \u00a0 Rodrigo Muzquiz PhD, Biochemistry, 2024 Email First\u2026","rel":"","context":"Similar post","block_context":{"text":"Similar post","link":""},"img":{"alt_text":"Picture of Joe Hazel","src":"https:\/\/i0.wp.com\/research.cbc.osu.edu\/foster.281\/wp-content\/uploads\/2025\/01\/Hazel_Joseph.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/research.cbc.osu.edu\/foster.281\/wp-content\/uploads\/2025\/01\/Hazel_Joseph.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/research.cbc.osu.edu\/foster.281\/wp-content\/uploads\/2025\/01\/Hazel_Joseph.jpg?resize=525%2C300&ssl=1 1.5x"},"classes":[]},{"id":43,"url":"https:\/\/research.cbc.osu.edu\/foster.281\/links\/","url_meta":{"origin":898,"position":3},"title":"Links","author":"Eric Danhart","date":"August 11, 2013","format":false,"excerpt":"OSU Seminar Series of Interest MLS (Molecular Life Sciences\/OSBP+MCDB) Chemistry Department Seminars RNA Center Seminars Biophysics Program Seminars Neuroscience Graduate Program NMR@OSU Interest Group Research Programs at OSU Ohio State Biochemistry Program (OSBP) Ohio State Biophysics Program Department of Chemistry and Biochemistry Molecular Biophysics Research Expertise at OSU Research Centers\u2026","rel":"","context":"Similar post","block_context":{"text":"Similar post","link":""},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1530,"url":"https:\/\/research.cbc.osu.edu\/foster.281\/teaching\/","url_meta":{"origin":898,"position":4},"title":"Courses","author":"Mark Foster","date":"June 3, 2019","format":false,"excerpt":"Mark P. Foster Undergraduate Biochemistry 4999: Thesis Research Biochemistry 5721 Physical Biochemistry (Syllabus) Graduate Biochemistry 6701: Molecular Biology (Syllabus) Biochemistry 6761: Macromolecular Structure and Function (Syllabus) Biochemistry 6765: Physical Biochemistry (Syllabus) OSBP 7700: Student Seminar Biochemistry 8900: Bio-Macromolecular NMR (Syllabus) Biochemistry 8999: Thesis Research","rel":"","context":"Similar post","block_context":{"text":"Similar post","link":""},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":16,"url":"https:\/\/research.cbc.osu.edu\/foster.281\/publications\/","url_meta":{"origin":898,"position":5},"title":"Publications","author":"Eric Danhart","date":"August 8, 2013","format":false,"excerpt":"Selected Publications Ma X, Baktina M, Shulgina I, Cantara WA, Nagy ABK, Goto Y, Suga H, Foster MP, Musier-Forsyth K. Structural basis of tRNAPro acceptor stem recognition by a bacterial trans-editing domain. Nucleic Acids Res. 2023 May 8; 51(8):3988-3999. doi: 10.1093\/nar\/gkad192. Li W, Norris AS, Lichtenthal K, Kelly S, Ihms\u2026","rel":"","context":"Similar post","block_context":{"text":"Similar post","link":""},"img":{"alt_text":"rid_logo","src":"https:\/\/i0.wp.com\/research.cbc.osu.edu\/foster.281\/wp-content\/uploads\/2013\/08\/rid_logo.gif?ssl=1&resize=350%2C200","width":350,"height":200},"classes":[]}],"_links":{"self":[{"href":"https:\/\/research.cbc.osu.edu\/foster.281\/wp-json\/wp\/v2\/pages\/898","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/research.cbc.osu.edu\/foster.281\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/research.cbc.osu.edu\/foster.281\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/research.cbc.osu.edu\/foster.281\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/research.cbc.osu.edu\/foster.281\/wp-json\/wp\/v2\/comments?post=898"}],"version-history":[{"count":24,"href":"https:\/\/research.cbc.osu.edu\/foster.281\/wp-json\/wp\/v2\/pages\/898\/revisions"}],"predecessor-version":[{"id":1797,"href":"https:\/\/research.cbc.osu.edu\/foster.281\/wp-json\/wp\/v2\/pages\/898\/revisions\/1797"}],"wp:attachment":[{"href":"https:\/\/research.cbc.osu.edu\/foster.281\/wp-json\/wp\/v2\/media?parent=898"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}