{"id":1267,"date":"2017-03-03T09:29:33","date_gmt":"2017-03-03T14:29:33","guid":{"rendered":"https:\/\/research.cbc.osu.edu\/foster.281\/?p=1267"},"modified":"2017-03-03T09:32:03","modified_gmt":"2017-03-03T14:32:03","slug":"new-nih-r01-funded","status":"publish","type":"post","link":"https:\/\/research.cbc.osu.edu\/foster.281\/2017\/03\/03\/new-nih-r01-funded\/","title":{"rendered":"New NIH R01: Protein Dynamics in Site-Specific DNA Recombination"},"content":{"rendered":"<p>NIGMS has funded our project R01\u00a0<span id=\"spnPNUMB\">GM122432<\/span>: <a title=\"Click to view Project Description\" href=\"https:\/\/projectreporter.nih.gov\/project_info_description.cfm?aid=9264144&amp;icde=33285698&amp;ddparam=&amp;ddvalue=&amp;ddsub=&amp;cr=2&amp;csb=default&amp;cs=ASC&amp;pball=\">PROTEIN DYNAMICS IN SITE-SPECIFIC DNA RECOMBINATION.<\/a> The work will fill critical gaps in our understanding of the mechanisms of site specific DNA recombination as exemplified by Cre, a commonly used genetic engineering tool. The studies will provide new insights that could facilitate the design of recombinase variants with defined DNA sequence specificity and improved efficiency, and may suggest new avenues for controlling its activity.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>NIGMS has funded our project R01\u00a0GM122432: PROTEIN DYNAMICS IN SITE-SPECIFIC DNA RECOMBINATION. The work will fill critical gaps in our understanding of the mechanisms of site specific DNA recombination as exemplified by Cre, a commonly used genetic engineering tool. The<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":true,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[1],"tags":[],"class_list":["post-1267","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p7sxod-kr","jetpack-related-posts":[{"id":939,"url":"https:\/\/research.cbc.osu.edu\/foster.281\/2016\/04\/28\/enc-2016\/","url_meta":{"origin":1267,"position":0},"title":"ENC 2016","author":"Mark Foster","date":"April 28, 2016","format":false,"excerpt":"Eric, Aparna, Vibhuti, Xiao and Weicheng presented at the 57th ENC in Pittsburgh Poster titles: Induced fit binding involving a dynamic helix confers acceptor stem recognition of mischarged Ala-tRNAPro by a bacterial trans-editing domain Eric M. Danhart, Xiao Ma, Lexie Kuzmishin, Brianne Sanford, Marina Bakhtina, Karin Musier-Forsyth, and Mark P.\u2026","rel":"","context":"Similar post","block_context":{"text":"Similar post","link":""},"img":{"alt_text":"IMG_20160411_132357","src":"https:\/\/i0.wp.com\/research.cbc.osu.edu\/foster.281\/wp-content\/uploads\/2016\/04\/IMG_20160411_132357-1024x768.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/research.cbc.osu.edu\/foster.281\/wp-content\/uploads\/2016\/04\/IMG_20160411_132357-1024x768.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/research.cbc.osu.edu\/foster.281\/wp-content\/uploads\/2016\/04\/IMG_20160411_132357-1024x768.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/research.cbc.osu.edu\/foster.281\/wp-content\/uploads\/2016\/04\/IMG_20160411_132357-1024x768.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":1317,"url":"https:\/\/research.cbc.osu.edu\/foster.281\/2017\/06\/06\/new-4-year-grant-funded-dynamics-and-allostery-in-protein-rna-regulation\/","url_meta":{"origin":1267,"position":1},"title":"New 4-year Grant Funded: Dynamics and Allostery in Protein-RNA Regulation","author":"Mark Foster","date":"June 6, 2017","format":false,"excerpt":"This new NIH R01 is a collaborative grant that funds our research to understand the mechanisms of allosteric regulation of RNA binding by oligomeric proteins, using the undecameric trp RNA binding attenuation protein (TRAP) as a model system. In addition, we study how TRAP binding to the trp leader RNA\u2026","rel":"","context":"Similar post","block_context":{"text":"Similar post","link":""},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1208,"url":"https:\/\/research.cbc.osu.edu\/foster.281\/2016\/12\/09\/postdoctoral-positions-available\/","url_meta":{"origin":1267,"position":2},"title":"Postdoctoral positions available","author":"Mark Foster","date":"December 9, 2016","format":false,"excerpt":"Postdoctoral Positions in NMR Structural Biology, Columbus Ohio. Two NIH-funded postdoctoral positions are available immediately (starting January 2017) for NMR studies of protein-protein and protein-nucleic acid interactions. Funded projects involve characterizing interactions between eukaryotic transcription factors and their host and viral binding partners, development of small molecule inhibitors of the\u2026","rel":"","context":"Similar post","block_context":{"text":"Similar post","link":""},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1789,"url":"https:\/\/research.cbc.osu.edu\/foster.281\/2022\/02\/26\/phase-sensitive-nd-data-processing-tips-from-frank-delaglio\/","url_meta":{"origin":1267,"position":3},"title":"Phase-Sensitive nD data Processing Tips from Frank Delaglio","author":"Mark Foster","date":"February 26, 2022","format":false,"excerpt":"(Quoted from Frank Delaglio's NMRPipe Yahoo group, since migrated to nmrpipe@groups.io) Greetings, Dear Pipers, In the various phase-sensitive multidimensional experiments, the real and imaginary parts of the indirect dimensions are generated via separate measurements. Ideally, these are cos(t) for the real part, and -sin(t) for the imaginary part. Sometimes, ether\u2026","rel":"","context":"In \"delaglio\"","block_context":{"text":"delaglio","link":"https:\/\/research.cbc.osu.edu\/foster.281\/tag\/delaglio\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1179,"url":"https:\/\/research.cbc.osu.edu\/foster.281\/2016\/09\/23\/brandon-crowe-defends-his-phd-thesis\/","url_meta":{"origin":1267,"position":4},"title":"Brandon Crowe defends his PhD thesis!","author":"Mark Foster","date":"September 23, 2016","format":false,"excerpt":"Brandon Crowe, BS Magna Cum Laude, defends his thesis in the Ohio State Biochemistry Program, \"Protein-Protein and Protein-Nucleic Acids Interactions Important for Catalytic Activity and Recruitment of Viral Genomes to Host Chromatin\", to earn a PhD from the Ohio State University. Congratulations Brandon!","rel":"","context":"Similar post","block_context":{"text":"Similar post","link":""},"img":{"alt_text":"Brandon Looks Forward","src":"https:\/\/i0.wp.com\/research.cbc.osu.edu\/foster.281\/wp-content\/uploads\/2016\/09\/IMG_0983-1024x768.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/research.cbc.osu.edu\/foster.281\/wp-content\/uploads\/2016\/09\/IMG_0983-1024x768.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/research.cbc.osu.edu\/foster.281\/wp-content\/uploads\/2016\/09\/IMG_0983-1024x768.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/research.cbc.osu.edu\/foster.281\/wp-content\/uploads\/2016\/09\/IMG_0983-1024x768.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]}],"_links":{"self":[{"href":"https:\/\/research.cbc.osu.edu\/foster.281\/wp-json\/wp\/v2\/posts\/1267","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/research.cbc.osu.edu\/foster.281\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/research.cbc.osu.edu\/foster.281\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/research.cbc.osu.edu\/foster.281\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/research.cbc.osu.edu\/foster.281\/wp-json\/wp\/v2\/comments?post=1267"}],"version-history":[{"count":3,"href":"https:\/\/research.cbc.osu.edu\/foster.281\/wp-json\/wp\/v2\/posts\/1267\/revisions"}],"predecessor-version":[{"id":1270,"href":"https:\/\/research.cbc.osu.edu\/foster.281\/wp-json\/wp\/v2\/posts\/1267\/revisions\/1270"}],"wp:attachment":[{"href":"https:\/\/research.cbc.osu.edu\/foster.281\/wp-json\/wp\/v2\/media?parent=1267"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/research.cbc.osu.edu\/foster.281\/wp-json\/wp\/v2\/categories?post=1267"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/research.cbc.osu.edu\/foster.281\/wp-json\/wp\/v2\/tags?post=1267"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}