{"id":1280,"date":"2017-04-11T12:13:09","date_gmt":"2017-04-11T16:13:09","guid":{"rendered":"https:\/\/research.cbc.osu.edu\/foster.281\/?p=1280"},"modified":"2017-04-11T12:13:09","modified_gmt":"2017-04-11T16:13:09","slug":"new-paper-mechanistic-models-fit-to-variable-temperature-calorimetric-data-provide-insights-into-cooperativity","status":"publish","type":"post","link":"https:\/\/research.cbc.osu.edu\/foster.281\/2017\/04\/11\/new-paper-mechanistic-models-fit-to-variable-temperature-calorimetric-data-provide-insights-into-cooperativity\/","title":{"rendered":"New Paper: Mechanistic models fit to variable temperature calorimetric data provide insights into cooperativity"},"content":{"rendered":"<p>Elihu C. Ihms, Ian R. Kleckner, Paul Gollnick, Mark P. Foster, &#8220;Mechanistic models fit to variable temperature calorimetric data provide insights into cooperativity&#8221; <em>Biophysical Journal<\/em> 112 ( 7) 2017,\u00a0 1328\u20131338 <a href=\"https:\/\/authors.elsevier.com\/a\/1UsgL_9FM4eH5\">https:\/\/authors.elsevier.com\/a\/1UsgL_9FM4eH5<\/a><\/p>\n<p>We use a nearest-neighbor formalism to generate a simplified binding polynomial for the 2048 configurations of TRAP + 0-11 Trp ligands, and show that temperature dependence of the ITC data provides sufficient data to constrain parameter space and define microscopic binding and interaction thermodynamics.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Elihu C. Ihms, Ian R. Kleckner, Paul Gollnick, Mark P. Foster, &#8220;Mechanistic models fit to variable temperature calorimetric data provide insights into cooperativity&#8221; Biophysical Journal 112 ( 7) 2017,\u00a0 1328\u20131338 https:\/\/authors.elsevier.com\/a\/1UsgL_9FM4eH5 We use a nearest-neighbor formalism to generate a simplified<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[],"class_list":["post-1280","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p7sxod-kE","jetpack-related-posts":[{"id":1094,"url":"https:\/\/research.cbc.osu.edu\/foster.281\/2016\/06\/15\/pepsi-presents-her-work-at-the-asms\/","url_meta":{"origin":1280,"position":0},"title":"Pepsi presents her work at the ASMS","author":"Mark Foster","date":"June 15, 2016","format":false,"excerpt":"Pepsi (Melody) Holquist presented her poster, \"Using Native MS to Inform Statistical Thermodynamic Models of Cooperativity,\" at the 2016 American Society for Mass Spectrometry conference in San Antonio,TX","rel":"","context":"Similar post","block_context":{"text":"Similar post","link":""},"img":{"alt_text":"20160607_125019","src":"https:\/\/i0.wp.com\/research.cbc.osu.edu\/foster.281\/wp-content\/uploads\/2016\/06\/20160607_125019-e1466011932360-300x202.jpg?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]},{"id":939,"url":"https:\/\/research.cbc.osu.edu\/foster.281\/2016\/04\/28\/enc-2016\/","url_meta":{"origin":1280,"position":1},"title":"ENC 2016","author":"Mark Foster","date":"April 28, 2016","format":false,"excerpt":"Eric, Aparna, Vibhuti, Xiao and Weicheng presented at the 57th ENC in Pittsburgh Poster titles: Induced fit binding involving a dynamic helix confers acceptor stem recognition of mischarged Ala-tRNAPro by a bacterial trans-editing domain Eric M. Danhart, Xiao Ma, Lexie Kuzmishin, Brianne Sanford, Marina Bakhtina, Karin Musier-Forsyth, and Mark P.\u2026","rel":"","context":"Similar post","block_context":{"text":"Similar post","link":""},"img":{"alt_text":"IMG_20160411_132357","src":"https:\/\/i0.wp.com\/research.cbc.osu.edu\/foster.281\/wp-content\/uploads\/2016\/04\/IMG_20160411_132357-1024x768.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/research.cbc.osu.edu\/foster.281\/wp-content\/uploads\/2016\/04\/IMG_20160411_132357-1024x768.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/research.cbc.osu.edu\/foster.281\/wp-content\/uploads\/2016\/04\/IMG_20160411_132357-1024x768.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/research.cbc.osu.edu\/foster.281\/wp-content\/uploads\/2016\/04\/IMG_20160411_132357-1024x768.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":1317,"url":"https:\/\/research.cbc.osu.edu\/foster.281\/2017\/06\/06\/new-4-year-grant-funded-dynamics-and-allostery-in-protein-rna-regulation\/","url_meta":{"origin":1280,"position":2},"title":"New 4-year Grant Funded: Dynamics and Allostery in Protein-RNA Regulation","author":"Mark Foster","date":"June 6, 2017","format":false,"excerpt":"This new NIH R01 is a collaborative grant that funds our research to understand the mechanisms of allosteric regulation of RNA binding by oligomeric proteins, using the undecameric trp RNA binding attenuation protein (TRAP) as a model system. In addition, we study how TRAP binding to the trp leader RNA\u2026","rel":"","context":"Similar post","block_context":{"text":"Similar post","link":""},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1350,"url":"https:\/\/research.cbc.osu.edu\/foster.281\/2017\/08\/01\/nmrpipe-processing-tips-from-alex-hansen\/","url_meta":{"origin":1280,"position":3},"title":"NMRPipe Processing Tips from Alex Hansen","author":"Mark Foster","date":"August 1, 2017","format":false,"excerpt":"Hello, I've noticed a few common 'annoyances' that everyone tends to deal with when processing nmr data in one way or another and I thought I'd offer a few solutions: 1) Getting started with nmrPipe\/nmrDraw: Converting data in Topspin Learning nmrPipe can be a hassle, especially if you're not horribly\u2026","rel":"","context":"Similar post","block_context":{"text":"Similar post","link":""},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1267,"url":"https:\/\/research.cbc.osu.edu\/foster.281\/2017\/03\/03\/new-nih-r01-funded\/","url_meta":{"origin":1280,"position":4},"title":"New NIH R01: Protein Dynamics in Site-Specific DNA Recombination","author":"Mark Foster","date":"March 3, 2017","format":false,"excerpt":"NIGMS has funded our project R01\u00a0GM122432: PROTEIN DYNAMICS IN SITE-SPECIFIC DNA RECOMBINATION. The work will fill critical gaps in our understanding of the mechanisms of site specific DNA recombination as exemplified by Cre, a commonly used genetic engineering tool. The studies will provide new insights that could facilitate the design\u2026","rel":"","context":"Similar post","block_context":{"text":"Similar post","link":""},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1789,"url":"https:\/\/research.cbc.osu.edu\/foster.281\/2022\/02\/26\/phase-sensitive-nd-data-processing-tips-from-frank-delaglio\/","url_meta":{"origin":1280,"position":5},"title":"Phase-Sensitive nD data Processing Tips from Frank Delaglio","author":"Mark Foster","date":"February 26, 2022","format":false,"excerpt":"(Quoted from Frank Delaglio's NMRPipe Yahoo group, since migrated to nmrpipe@groups.io) Greetings, Dear Pipers, In the various phase-sensitive multidimensional experiments, the real and imaginary parts of the indirect dimensions are generated via separate measurements. Ideally, these are cos(t) for the real part, and -sin(t) for the imaginary part. Sometimes, ether\u2026","rel":"","context":"In \"delaglio\"","block_context":{"text":"delaglio","link":"https:\/\/research.cbc.osu.edu\/foster.281\/tag\/delaglio\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]}],"_links":{"self":[{"href":"https:\/\/research.cbc.osu.edu\/foster.281\/wp-json\/wp\/v2\/posts\/1280","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/research.cbc.osu.edu\/foster.281\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/research.cbc.osu.edu\/foster.281\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/research.cbc.osu.edu\/foster.281\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/research.cbc.osu.edu\/foster.281\/wp-json\/wp\/v2\/comments?post=1280"}],"version-history":[{"count":2,"href":"https:\/\/research.cbc.osu.edu\/foster.281\/wp-json\/wp\/v2\/posts\/1280\/revisions"}],"predecessor-version":[{"id":1282,"href":"https:\/\/research.cbc.osu.edu\/foster.281\/wp-json\/wp\/v2\/posts\/1280\/revisions\/1282"}],"wp:attachment":[{"href":"https:\/\/research.cbc.osu.edu\/foster.281\/wp-json\/wp\/v2\/media?parent=1280"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/research.cbc.osu.edu\/foster.281\/wp-json\/wp\/v2\/categories?post=1280"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/research.cbc.osu.edu\/foster.281\/wp-json\/wp\/v2\/tags?post=1280"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}