The Gopalan Lab


We are looking for highly motivated student researchers interested in understanding protein-aided RNA catalysis and novel metabolic pathways in Salmonella. Interested graduate students from the Chemistry and Biochemistry Graduate Program; Microbiology Graduate Program; Molecular, Cellular, and Developmental Biology (MCDB) Program; Ohio State Biochemistry Program (OSBP); and Ohio State Biophysics Graduate Program can contact Dr. Gopalan for more information!

Announcements

May 21, 2018
Welcome to Summer Undergraduate Research Experience (SURE) Fellow Wenxin (Iris) Chen! Iris is a rising 3rd year majoring in Biochemistry at Denison University (Granville, OH) and will investigate phosphorylation of glycated proteins by fructosamine kinases.
May 9, 2018
Congratulations to Blake Szkoda for receiving a Cellular, Biochemical, and Molecular Sciences Training Program (CMBP) fellowship for the 2018-2019 academic year! CMBP is “designed to attract top-tier graduate students; prepare them for life-sciences research careers in academia, government, or industry; and advance research pursuits in areas related to human health, physiology, and disease”.
May 7, 2018
Anindita Sengupta and Tien-Hao Chen presented a poster entitled “Development of Salmonella-specific antibiotics by elucidating the mechanism of the FraB deglycase and high-throughput compound screening” at the Department of Chemistry and Biochemistry’s 2018 Inaugural Industry Day here at OSU.
May 6, 2018
Congratulations to Dan Dyzslewski and Seth Lyon for graduating with Bachelor of Science degrees at Spring Commencement today!
April 20, 2018
Welcome to new Microbiology graduate student Sravya Kovvali! Sravya earned a B.Tech. in Biotechnology from D.Y. Patil University in Mumbai, India.
April 10, 2018
Congratulations to Dr. Venkat Gopalan, who was jointly awarded the OSU College of Arts and Sciences Diversity Enhancement Faculty Award with Drs. Susan Cole (Department of Molecular Genetics), Jane Jackman (Department of Chemistry and Biochemistry ), and Amanda Simcox (Department of Molecular Genetics; not pictured). The award “recognize[s] the outstanding accomplishments of any faculty member or team of faculty members in the College of Arts and Sciences whose research, teaching, and/or service/outreach activities promote diversity and support a culture that embraces and exhibits inclusive excellence, community, and openness.”
April 6, 2018
Congratulations to Seth Lyon for winning first place in the “Molecular Biophysics & Chemical Biology” division at the Richard J. and Martha D. Denman Undergraduate Research Forum for his poster entitled “Synthesis of 5’-chemically-modified RNAs is enhanced by a mutant T7 RNA polymerase”!
April 3, 2018
Dan Dyszlewski and Seth Lyon presented posters in the “Molecular Biophysics & Chemical Biology” division at the Richard J. and Martha D. Denman Undergraduate Research Forum here at OSU. Dan’s poster was entitled “Biochemical studies of bacterial kinases and deglycases that convert Amadori products to energy-yielding metabolites: prospects for antibiotic discovery” while Seth’s was entitled “Synthesis of 5’-chemically-modified RNAs is enhanced by a mutant T7 RNA polymerase”.
March 28, 2018
Congratulations to Matt Jajowka and Yehong Qiu for receiving 2018-2019 Gary Booth Scholarships from the OSU Department of Chemistry and Biochemistry!
March 28, 2018
Congratulations to Seth Lyon for successfully defending his undergraduate research thesis entitled “A T7 RNA polymerase mutant enhances the yield of 5′-guanosine-analog-initiated RNAs”! He will officially graduate with honors research distinction in Biochemistry (and a minor in Computer and Information Science) this May at Spring Commencement.
March 21, 2018
Congratulations to Seth Lyon for winning a Best Poster Award at the Natural and Mathematical Sciences Undergraduate Research Forum for his poster entitled “Synthesis of 5′-chemically-modified RNAs is enhanced by a mutant T7 RNA polymerase”!
February 21, 2018
Congratulations to Stella Lai, former postdoctoral researcher Pradip Biswas, and former graduate student Andy Jones for co-authoring the paper “Development of a high-throughput assay for rapid screening of butanologenic strains”, now published in Scientific Reports! This work was part of a collaborative effort with Chidozie Victor Agu, Victor Ujor, and Thaddeus Chukwuemeka Ezeji at the Ohio Agricultural Research and Development Center (OARDC).
February 20, 2018
Congratulations to Blake Szkoda for co-authoring the paper “Salmonella-mediated inflammation eliminates competitors for fructose-asparagine in the gut”, now accepted for publication in Infection and Immunity! This work was part of a collaborative effort with Jikang Wu, Anice Sabag-Daigle, Mikayla Borton, Linnea Kop, Prosper Boyaka, Kelly Wrighton, Vicki Wysocki, and Brian Ahmer here at OSU and Brooke Deatherage Kaiser, Stephen Lindemann, Ryan Renslow, Siwei Wei, Carrie Nicora, Karl Weitz, Young-Mo Kim, Joshua Adkins, and Thomas Metz at the Pacific Northwest National Laboratory in Richland, WA.
February 14, 2018
Congratulations to Drs. Jyan-Chyun Jang (OSU Department of Horticulture and Crop Science) and Venkat Gopalan for receiving funding through the SEEDS: The OARDC Research Enhancement Competitive Grants Program for their proposal entitled “Genome-wide mapping of plant tandem zinc finger protein–RNA interactions for crop improvement”!
January 9, 2018
Congratulations to Seth Lyon for having his paper “A T7 RNA polymerase mutant enhances the yield of 5′-thienoguanosine-initiated RNAs” highlighted on the cover of volume 19, issue 2, of ChemBioChem!
December 10, 2017
Congratulations to Anindita Sengupta for co-authoring the paper “Identification of bacterial species that can utilize fructose-asparagine”, now accepted for publication in Applied and Environmental Microbiology! This work was part of a collaborative effort with Anice Sabag-Daigle, Jikang Wu, Mikayla Borton, Kelly Wrighton, Vicki Wysocki, and Brian Ahmer here at OSU.
November 7, 2017
Congratulations to Seth Lyon for having his paper “A T7 RNA polymerase mutant enhances the yield of 5′-thienoguanosine-initiated RNAs” accepted into ChemBioChem!
October 13-14, 2017
Congratulations to Seth Lyon for winning the Outstanding Undergraduate Oral Presentation Award at the 19th Annual Rustbelt RNA Meeting in Indianapolis, IN, for his presentation entitled “A mutant T7 RNA polymerase enhances 5′-incorporation of guanosine analogs into RNA”!
October 13-14, 2017
Stella Lai and Ila Marathe presented posters at the 19th Annual Rustbelt RNA Meeting in Indianapolis, IN. Stella’s poster was entitled “Characterization of kink-turns in RNase P RNAs from Halobacteria” while Ila’s was entitled “Use of FRET and SHAPE-Seq to elucidate structure-function relationships in archaeal RNase P, a multi-subunit catalytic ribonucleoprotein”.
October 13-14, 2017
Seth Lyon gave an oral presentation at the 19th Annual Rustbelt RNA Meeting in Indianapolis, IN. His presentation was entitled “A mutant T7 RNA polymerase enhances 5′-incorporation of guanosine analogs into RNA”.
October 13-14, 2017
Seth Lyon, Stella Lai, Blake Szkoda, and Ila Marathe attended the 19th Annual Rustbelt RNA Meeting in Indianapolis, IN.
September 14, 2017
Dan Dyszlewski and Seth Lyon presented posters at the Fall Undergraduate Research Office Symposium here at OSU. Dan’s poster was entitled “Comparative biochemical studies of kinases and deglycases that convert Amadori products to common metabolites” while Seth’s was entitled “Synthesis of 5′-chemically-modified RNAs is enhanced by a mutant T7 RNA polymerase”.
August 18, 2017
Congratulations to Anindita Sengupta and former postdoctoral researcher Pradip Biswas for co-authoring the paper “Salmonella FraE, an asparaginase homolog, contributes to fructose-asparagine but not asparagine utilization”, now accepted for publication in Journal of Bacteriology! This work was part of a collaborative effort with Anice Sabag-Daigle, Henry Blunk, Mary Cron, Alexander Bogard, Edward Behrman, and Brian Ahmer here at OSU.
August 16-19, 2017
Tien-Hao Chen presented his poster entitled “Substrate Recognition by Arabidopsis Protein-Only RNase P Isoenzymes: Insights into Catalysis” at the First Conference on Biomotors, Virus Assembly, and Nanobiotechnology Applications here at OSU.
August 16-19, 2017
Ila Marathe, Tien-Hao Chen, Blake Szkoda, Stella Lai, and Lien Lai (not pictured) attended the First Conference on Biomotors, Virus Assembly, and Nanobiotechnology Applications here at OSU. Venkat Gopalan was a session chair (with Piotr Grodzinski from NCI/NIH) for the “Biophysical and Single Molecule Studies of Biomotors and RNA” session.
August 14, 2017
Welcome to new research assistant Jamison Law! Jamison earned a B.S. and an M.S. in Biology from Indiana University-Purdue University Fort Wayne (IPFW) in Fort Wayne, IN.
August 6, 2017
Congratulations to Stella Lai for officially receiving her Master of Science degree today at Summer Commencement!
August 5, 2017
Congratulations to Seth Lyon for completing a 45-mile bike ride from downtown Columbus to New Albany for Pelotonia today!
August 3, 2017
Congratulations to the newly minted Dr. Tien-Hao Chen for successfully defending his Ph.D. dissertation entitled “Elucidating substrate recognition and catalysis by protein-only RNase P”! He will officially graduate from the Chemistry and Biochemistry Graduate Program this December at Fall Commencement.
July 27, 2017
Jeffrin Wisel and Dechen Wangmo presented posters at the NSF REU poster session here at OSU. Jeffrin’s poster was entitled “Investigating the mechanism of inhibition of a Salmonella deglycase by aurintricarboxylic acid” while Dechen’s was entitled “Elucidating the structural basis for neurodegeneration caused by a mutation in tRNAArgUCU“.
June 4-9, 2017
Tien-Hao Chen gave an oral presentation at the Gordon-Kenan Research Seminar on Nucleic Acids and presented a poster at the “Nucleic Acids” Gordon Research Conference in Biddeford, ME. Both presentations were entitled “Substrate Recognition by Arabidopsis Proteinaceous RNase P Isoenzymes: Insights into Catalysis”.
June 1-5, 2017
Anindita Sengupta presented her poster entitled “Uncovering the Mechanism of Action of a Salmonella Deglycase, a Potential Drug Target” at the annual American Society for Microbiology (ASM) Microbe Meeting in New Orleans, LA.
May 30, 2017
Welcome to National Science Foundation (NSF) Research Experiences for Undergraduates (REU) students Jeffrin Wisel and Dechen Wangmo! Jeffrin is a rising 4th year majoring in Biochemistry here at OSU and will study the mechanism of inhibition of a Salmonella degylcase by small molecules. Dechen, who will primarily work with Dr. Kotaro Nakanishi, is a rising 4th year majoring in Genetics, Cell Biology, and Development at the University of Minnesota in Minneapolis, MN, and will study structural changes wrought by a mutation in tRNAArgUCU that causes neurodegeneration in mice.
May 16, 2017
Congratulations to Anindita Sengupta and former undergraduate students Angela Zabala, Si-Yu Tan, and Arthur Broadstock for having their paper “Characterization of an ionic liquid-tolerant ß-xylosidase from a marine-derived fungal endophyte” accepted into Biochemistry and Cell Biology! This work was part of a collaborative effort with Trichur Suryanarayanan at the Vivekananda Institute of Tropical Mycology in Chennai, India.
May 10, 2017
Welcome to new undergraduate researcher Dan Dyszlewski! Dan is a rising 4th year majoring in Biochemistry here at OSU.
May 9, 2017
Ila Marathe and Seth Lyon presented posters at the Cellular, Molecular, and Biochemical Sciences Training Program and Center for RNA Biology Annual Symposium here at OSU. Ila’s poster was entitled “Dissecting Structural and Functional Cooperation in RNase P, a Multi-Subunit Catalytic Ribonucleoprotein” while Seth’s was entitled “Utilization of an RNase P-based assay for accurate measurement of 5′-modification in tRNAs”.
May 7, 2017
Congratulations to Nick Thomsen for graduating with a Bachelor of Science degree at Spring Commencement today!
May 1, 2017
Congratulations to Seth Lyon for receiving a Pelotonia Undergraduate Research Fellowship! Pelotonia is a grassroots bike tour that raises millions of dollars each year for cancer research at OSU. Seth will study how mitochondrial DNA mutations and their effect on RNase P processing contribute to cancer.
April 24, 2017
Congratulations to Lien Lai, Stella Lai, Ila Marathe, and former graduate student Wen-Yi Chen for having their paper “A novel double kink-turn module in euryarchaeal RNase P RNAs” accepted into Nucleic Acids Research! This work was part of a collaborative effort with Akiko Tanimoto and Vicki Wysocki here at OSU and Eric Westhof at the University of Strasbourg in France.
April 24, 2017
Seth Lyon was featured in the “ASC Spotlight” series on the OSU College of Arts and Sciences website: https://artsandsciences.osu.edu/news-events/asc-spotlights/seth-lyon
April 19, 2017
Congratulations to Stella Lai for successfully defending her Master’s thesis entitled “Defective tRNA Processing Contributes to Neurodegeneration in Mice”! She will officially graduate from the Anatomy Graduate Program this August at Summer Commencement.
April 18, 2017
Congratulations to Seth Lyon for receiving an Edward G. Mayers Scholarship from the OSU College of Arts and Sciences to conduct research in the lab this summer!
April 14, 2017
Congratulations to Seth Lyon for receiving an Undergraduate Research Scholarship from the OSU College of Arts and Sciences to conduct research in the lab this upcoming school year!
April 10, 2017
Congratulations to Nick Thomsen for winning a Best Poster Award at the Natural and Mathematical Sciences Undergraduate Research Forum for his poster entitled “Uncovering the biochemical properties of the Salmonella deglycase FraB, a potential drug target”!
April 10, 2017
Seth Lyon and Nick Thomsen presented posters in the Chemical and Biochemical Sciences division at the Natural and Mathematical Sciences Undergraduate Research Forum here at OSU. Seth’s poster was entitled “Utilization of an RNase P-based assay for accurate measurement of 5′-modification in tRNAs” while Nick’s was entitled “Uncovering the biochemical properties of the Salmonella deglycase FraB, a potential drug target”.
April 10, 2017
Welcome to new OSBP graduate student Blake Szkoda! Blake earned a B.S. in Biochemistry from Marietta College in Marietta, OH.
March 29, 2017
Congratulations to Seth Lyon for winning first place in the “Addressing Complex Questions in Chemical and Biochemical Sciences” division at the Richard J. and Martha D. Denman Undergraduate Research Forum for his poster entitled “Utilization of an RNase P-based assay for accurate measurement of 5′-modification in tRNAs”!
March 29, 2017
Seth Lyon and Nick Thomsen presented posters in the “Addressing Complex Questions in Chemical and Biochemical Sciences” division at the Richard J. and Martha D. Denman Undergraduate Research Forum here at OSU. Seth’s poster was entitled “Utilization of an RNase P-based assay for accurate measurement of 5′-modification in tRNAs” while Nick’s was entitled “Uncovering the biochemical properties of the Salmonella deglycase FraB, a potential drug target”.
March 28, 2017
Congratulations to Humza Qureshi for receiving a 2017-2018 Chemical Abstracts Service Endowment Scholarship Award from the Department of Chemistry and Biochemistry!
March 25, 2017
Seth Lyon and Nick Thomsen presented posters at The Columbus Section Undergraduate and Graduate Poster Competition, which was sponsored by the Columbus Section of the American Chemical Society (ACS) and the OSU Chemistry and Biochemistry Club, and held here in Columbus, OH. Seth’s poster was entitled “Utilization of an RNase P-based assay for accurate measurement of 5′-modification in tRNAs” while Nick’s was entitled “Uncovering the biochemical properties of the Salmonella deglycase FraB, a potential drug target”.
March 22, 2017
Congratulations to Seth Lyon for receiving a 2017-2018 Gary Booth Scholarship from the OSU Department of Chemistry and Biochemistry!