{"id":10,"date":"2015-03-18T16:50:42","date_gmt":"2015-03-18T20:50:42","guid":{"rendered":"https:\/\/research.cbc.osu.edu\/jaroniec.1\/?page_id=10"},"modified":"2023-10-30T11:51:13","modified_gmt":"2023-10-30T15:51:13","slug":"research","status":"publish","type":"page","link":"https:\/\/research.cbc.osu.edu\/jaroniec.1\/research\/","title":{"rendered":"Research Summary"},"content":{"rendered":"<p>Our research is aimed at understanding mechanism and function in large protein and protein-nucleic acid complexes and assemblies of fundamental importance in biology via atomistic level characterization of biomacromolecular structure, conformational dynamics and interactions. We employ a highly interdisciplinary approach, which includes the development and applications of multidimensional nuclear magnetic resonance (NMR) techniques in the solid-state and in solution, high-resolution cryo-electron microscopy, atomic force microscopy, scanning tunneling electron microscopy as well as complementary biophysical, chemical, molecular biology and computational tools.<\/p>\n<p>The major current research directions include:<\/p>\n<ul>\n<li>elucidation of the structural basis of strain and cross-seeding barrier phenomena in mammalian prion protein amyloids<\/li>\n<li>characterization of chromatin structure, dynamics and interactions with particular focus on the role of dynamic histone protein tail domains in mediating chromatin compaction and interactions with regulatory proteins<\/li>\n<li>characterization of DNA base pairing and hydrogen bonding in large protein-DNA complexes<\/li>\n<li>development of paramagnetic solid-state NMR methods for rapid protein structure determination<\/li>\n<\/ul>\n<p>For the most detailed and up-to-date information on our research please see the <a href=\"https:\/\/research.cbc.osu.edu\/jaroniec.1\/publications\/\">publications<\/a>\u00a0page.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our research is aimed at understanding mechanism and function in large protein and protein-nucleic acid complexes and assemblies of fundamental importance in biology via atomistic level characterization of biomacromolecular structure, conformational dynamics and interactions. We employ a highly interdisciplinary approach, which includes the development and applications of multidimensional nuclear magnetic resonance (NMR) techniques in the [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-10","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/research.cbc.osu.edu\/jaroniec.1\/wp-json\/wp\/v2\/pages\/10","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/research.cbc.osu.edu\/jaroniec.1\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/research.cbc.osu.edu\/jaroniec.1\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/research.cbc.osu.edu\/jaroniec.1\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/research.cbc.osu.edu\/jaroniec.1\/wp-json\/wp\/v2\/comments?post=10"}],"version-history":[{"count":7,"href":"https:\/\/research.cbc.osu.edu\/jaroniec.1\/wp-json\/wp\/v2\/pages\/10\/revisions"}],"predecessor-version":[{"id":904,"href":"https:\/\/research.cbc.osu.edu\/jaroniec.1\/wp-json\/wp\/v2\/pages\/10\/revisions\/904"}],"wp:attachment":[{"href":"https:\/\/research.cbc.osu.edu\/jaroniec.1\/wp-json\/wp\/v2\/media?parent=10"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}