{"id":12,"date":"2026-04-01T20:11:14","date_gmt":"2026-04-01T20:11:14","guid":{"rendered":"https:\/\/research.cbc.osu.edu\/karasik.8\/?page_id=12"},"modified":"2026-05-01T14:40:33","modified_gmt":"2026-05-01T14:40:33","slug":"12-2","status":"publish","type":"page","link":"https:\/\/research.cbc.osu.edu\/karasik.8\/","title":{"rendered":""},"content":{"rendered":"\n<style>\n    \/* 1. LAYOUT & NAVIGATION *\/\n    .lab-wrap {\n        font-family: 'Helvetica Neue', Arial, sans-serif;\n        line-height: 1.8;\n        color: #222;\n        background-color: #f0f2f5;\n        overflow-x: hidden;\n    }\n\n    .lab-nav {\n        background: #1a252f;\n        color: #fff;\n        padding: 1.5rem 5%;\n        width: 100vw;\n        margin-left: calc(-50vw + 50%);\n        box-sizing: border-box;\n        position: sticky;\n        top: 0;\n        display: flex;\n        justify-content: space-between;\n        align-items: center;\n        z-index: 9999;\n        box-shadow: 0 4px 12px rgba(0,0,0,0.15);\n    }\n\n    .lab-nav .logo { font-size: 1.8rem; font-weight: 800; }\n\n    .lab-nav ul { list-style: none; display: flex; margin: 0; padding: 0; }\n\n    .lab-nav ul li { margin-left: 30px; }\n\n    .lab-nav ul li a {\n        color: #fff;\n        text-decoration: none !important;\n        font-weight: 600;\n        font-size: 1.2rem;\n        cursor: pointer;\n        transition: 0.3s;\n    }\n\n    .lab-nav ul li a:hover { color: #3498db; }\n\n    \/* 2. 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GRIDS & CARDS *\/\n    .lab-grid {\n        display: grid;\n        grid-template-columns: repeat(auto-fit, minmax(350px, 1fr));\n        gap: 30px;\n        margin-top: 20px;\n    }\n\n    .lab-card {\n        background: #f9f9f9;\n        padding: 2.2rem;\n        border-radius: 12px;\n        border-left: 8px solid #3498db;\n        box-shadow: 0 4px 6px rgba(0,0,0,0.02);\n    }\n\n    .lab-card img { border-radius: 8px; margin-bottom: 15px; height: auto; }\n\n    \/* NEWS STYLES *\/\n    .news-item {\n        margin-bottom: 30px;\n        padding-bottom: 20px;\n        border-bottom: 1px solid #eee;\n    }\n    .news-date {\n        display: inline-block;\n        background: #3498db;\n        color: white;\n        padding: 2px 10px;\n        border-radius: 4px;\n        font-size: 0.9rem;\n        font-weight: bold;\n        margin-bottom: 10px;\n    }\n\n    .pub-list { list-style: none; padding: 0; }\n    .pub-list li {\n        font-size: 1.2rem;\n        margin-bottom: 20px;\n        padding-bottom: 15px;\n        border-bottom: 1px solid #eee;\n    }\n\n    \/* 5. FOOTER *\/\n    .lab-footer {\n        text-align: center;\n        padding: 4rem;\n        background: #1a252f;\n        color: white;\n        width: 100vw;\n        margin-left: calc(-50vw + 50%);\n        box-sizing: border-box;\n        margin-top: 60px;\n    }\n\n    @media (max-width: 768px) {\n        .lab-nav { flex-direction: column; padding: 1rem; }\n        .lab-nav ul { padding-top: 15px; flex-wrap: wrap; justify-content: center; }\n        .lab-nav ul li { margin: 5px 10px; }\n        .lab-section { margin: 15px; padding: 2rem; }\n    }\n<\/style>\n\n<div class=\"lab-wrap\">\n    <nav class=\"lab-nav\">\n        <div class=\"logo\">Karasik Lab &#8211; OSU<\/div>\n        <ul>\n            <li><a onclick=\"navTo('home')\">Home<\/a><\/li>\n            <li><a onclick=\"navTo('news')\">News<\/a><\/li>\n            <li><a onclick=\"navTo('research')\">Research<\/a><\/li>\n            <li><a onclick=\"navTo('publications')\">Publications<\/a><\/li>\n            <li><a onclick=\"navTo('people')\">People<\/a><\/li>\n            <li><a onclick=\"navTo('contact')\">Contact<\/a><\/li>\n        <\/ul>\n    <\/nav>\n\n    <!-- HOME SECTION -->\n    <section id=\"lab-home\" class=\"lab-section active\">\n        <div style=\"text-align: center;\">\n            <h1>Welcome to the:<\/h1>\n            <img decoding=\"async\" src=\"https:\/\/research.cbc.osu.edu\/karasik.8\/wp-content\/uploads\/2026\/04\/logo_version3.jpeg\" style=\"max-width: 400px; border-radius: 10px; margin-bottom: 30px;\"> \n            <img decoding=\"async\" src=\"https:\/\/research.cbc.osu.edu\/karasik.8\/wp-content\/uploads\/2026\/04\/IMG_20260417_144143091-scaled.jpg\" style=\"max-width: 1000px; border-radius: 10px; margin-bottom: 30px; width: 100%;\">      \n            <p>We are a group of RNA enthusiasts working on unsolved scientific mysteries related to human health and disease. Our group is particularly interested in the biochemistry of different RNases and the effects of their activation in human cells.<\/p>\n        <\/div>\n    <\/section>\n\n    <!-- NEWS SECTION -->\n    <section id=\"lab-news\" class=\"lab-section\">\n        <h2>Latest News<\/h2>\n        <div class=\"lab-card\">\n            <div class=\"news-item\">\n                <span class=\"news-date\">May 2026<\/span>\n                <h3>Welcome Anakha!<\/h3>\n                <p>We are excited to welcome Anakha Shah as our OSU SURE summer intern. Looking forward to a great summer of research!<\/p>\n            <\/div>\n   <div class=\"news-item\">\n                <span class=\"news-date\">April 2026<\/span>\n                <h3>Welcome Daniel, Gabby &#038; Sydney!<\/h3>\n                <p>Graduate students Daniel, Gabby and Sydney joined the lab. Congratulations!  <\/p>\n            <\/div>\n<div class=\"news-item\">\n                <span class=\"news-date\">February 2026<\/span>\n                <h3>New Publication in RNA!<\/h3>\n                <p> Our latest work &#8220;Stalled translation on transcripts cleaved by RNase L&#8221; is now out in the journal <em>RNA<\/em>.<\/p>\n            <\/div>\n            <div class=\"news-item\" style=\"border-bottom: none;\">\n                <span class=\"news-date\">November 2025<\/span>\n                <h3>CRB Seed Grant Awarded<\/h3>\n                <p>The lab has received new funding for a collaborative project with the van Hoof lab to explore the connection between ISR and tRNA introns.  <\/p>\n            <\/div>\n        <\/div>\n    <\/section>\n\n    <!-- RESEARCH SECTION -->\n    <section id=\"lab-research\" class=\"lab-section\">\n        <h2>Research Areas<\/h2>\n        <div class=\"lab-grid\">\n            <div class=\"lab-card\">\n                <h3>RNases can cause the Ribotoxic Stress Response (RSR)<\/h3>\n                <p><\/p>\n            <\/div>\n            <div class=\"lab-card\">\n                <h3>PolyA tail remodeling during the innate immune response<\/h3>\n                <p><\/p>\n            <\/div>\n            <div class=\"lab-card\">\n                <h3>How do RNA modifications influence the innate immune response?<\/h3>\n                <p><\/p>\n            <\/div>\n            <div class=\"lab-card\">\n                <h3>Collaboration with the van Hoof lab<\/h3>\n                <p>How do lack of tRNA introns cause the Integrated Stress Response? <\/p>\n            <\/div>\n        <\/div>\n    <\/section>\n\n    <!-- PUBLICATIONS SECTION -->\n    <section id=\"lab-publications\" class=\"lab-section\">\n        <h2>Selected Publications<\/h2>\n        <ul class=\"pub-list\">\n            <li><strong>Karasik, A. et al. (2026).<\/strong> &#8220;Stalled translation on transcripts cleaved by RNase L activates signaling important for innate immunity.&#8221; <em>RNA<\/em>.<\/li>\n            <li><strong>Karasik, A. (2024).<\/strong> &#8220;The unusual role of Ribonuclease L in innate immunity, (review)&#8221; <em>WIRES RNA<\/em>.<\/li>\n            <li><strong>Karasik, A. (2024).<\/strong> &#8220;Endonucleolytic RNA cleavage drives changes in gene expression during the innate immune response&#8221; <em>Cell Reports<\/em>.<\/li>\n            <li><strong>Karasik, A. (2021).<\/strong> &#8220;RNase L mediated antiviral response triggers translation of non-coding mRNA sequences,&#8221; <em>Nucleic Acid Research<\/em>.<\/li>\n        <\/ul>\n        <p><a href=\"https:\/\/scholar.google.com\/citations?user=IDj77EIAAAAJ&#038;hl=en\" style=\"color: #3498db; font-weight: bold; text-decoration: none;\">Full list of publications on Google Scholar &rarr;<\/a><\/p>\n    <\/section>\n\n    <!-- PEOPLE SECTION -->\n    <section id=\"lab-people\" class=\"lab-section\">\n        <h2>Our Team<\/h2>\n        <div class=\"lab-grid\">\n            <div class=\"lab-card\">\n                <h3>Agnes Karasik, PhD<\/h3>\n                <img decoding=\"async\" src=\"https:\/\/research.cbc.osu.edu\/karasik.8\/wp-content\/uploads\/2026\/04\/faculty_097-scaled.jpg\" width=\"240\">\n                <p><strong>Principal Investigator<\/strong><\/p> \n                B.Sc.\/M.Sc. at E\u00f6tv\u00f6s Lor\u00e1nd University <br> Ph.D. at USUHS <br> Postdoc at NIH\n            <\/div>\n            <div class=\"lab-card\">\n                <h3>Allysan Nunes<\/h3>\n                <img decoding=\"async\" src=\"https:\/\/research.cbc.osu.edu\/karasik.8\/wp-content\/uploads\/2026\/04\/Ally.jpg\" width=\"215\">\n                <p><strong>Research Technician<\/strong><br>Ally graduated from Slippery Rock University and she is currently leading a project investigating changes in RNA modifications during the innate immune response.<\/p>\n            <\/div>\n            <div class=\"lab-card\">\n                <h3>Sydney Townsend <\/h3>\n                <p><strong>Graduate student (Biomedical Sciences)<\/strong><br>Sydney graduated from North Carolina A&#038;T State University. She is interested in polyA tail changes during the innate immune response and developing bioinfomatics pipelines and analyses.<\/p>\n            <\/div>\n            <div class=\"lab-card\">\n                <h3>Daniel Morgan<\/h3>\n                <img decoding=\"async\" src=\"https:\/\/research.cbc.osu.edu\/karasik.8\/wp-content\/uploads\/2026\/04\/Picture_DM.jpg\" width=\"215\">\n                <p><strong>Graduate student (Molecular Genetics)<\/strong><br>Daniel graduated from SUNY Brockport. He is interested in consequences of RNA breakage and cleavage in context of Cas13 enzymes.<\/p>\n            <\/div>\n<div class=\"lab-card\">\n                <h3>Gabriella Proctor <\/h3>\n <img decoding=\"async\" src=\"https:\/\/research.cbc.osu.edu\/karasik.8\/wp-content\/uploads\/2026\/05\/IMG_3628-scaled.jpg\" width=\"215\">\n                <p><strong>Graduate student (Molecular Genetics)<\/strong><br>Gabby graduated from Southern Utah University. She is interested in how RNA cleavage play a role during angiogenesis. <\/p>\n            <\/div>\n<div class=\"lab-card\">\n                <h3>Anakha Shah<\/h3>\n                <p><strong>OSU SURE summer intern<\/strong><br> <\/p>\n            <\/div>\n            <div class=\"lab-card\">\n                <h3>Past rotation students:<\/h3>\n                <p>Maddie Goodman (OSBP)<br>Caleb Clark (MCDB)<\/p>\n            <\/div>\n<div class=\"lab-card\">\n                <h3>Past lab members:<\/h3>\n                <img decoding=\"async\" src=\"https:\/\/research.cbc.osu.edu\/karasik.8\/wp-content\/uploads\/2026\/04\/Kenzie.jpg\" width=\"228\">\n                <p><strong>Kenzie Scarpitti, PhD, Postdoctoral Fellow<\/strong><br>Kenzie graduated from The Ohio State University. During her graduate studies she investigated the molecular mechanisms of translational control focusing on FMRP. As a postdoctoral fellow, she was interested in gene expression during the innate immune response. She is currently a Biologist at Battelle. <\/p>\n            <\/div>\n        <\/div>\n    <\/section>\n\n    <!-- CONTACT SECTION -->\n    <section id=\"lab-contact\" class=\"lab-section\">\n        <h2>Contact<\/h2>\n        <p>We are always looking for RNA lovers to join the Karasik Lab.<\/p>\n        <div class=\"lab-card\" style=\"max-width: 600px; border-left-color: #2c3e50;\">\n            <p><strong>Email:<\/strong> karasik.8@osu.edu<\/p>\n            <p><strong>Location:<\/strong> Biological Sciences Building, Room 774<\/p>\n        <\/div>\n    <\/section>\n\n    <footer class=\"lab-footer\">\n        &copy; 2026 Karasik Lab | The Ohio State University\n    <\/footer>\n<\/div>\n\n<script>\n    function navTo(id) {\n        \/\/ Hide all\n        const sections = document.querySelectorAll('.lab-section');\n        sections.forEach(s => s.classList.remove('active'));\n        \n        \/\/ Show target\n        const target = document.getElementById('lab-' + id);\n        if(target) {\n            target.classList.add('active');\n            window.scrollTo(0, 0);\n        }\n    }\n<\/script>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Karasik Lab &#8211; OSU Home News Research Publications People Contact Welcome to the: We are a group of RNA enthusiasts working on unsolved scientific mysteries related to human health and disease. Our group is particularly interested in the biochemistry of different RNases and the effects of their activation in human cells. Latest News May 2026 [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":14,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-12","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/research.cbc.osu.edu\/karasik.8\/index.php\/wp-json\/wp\/v2\/pages\/12","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/research.cbc.osu.edu\/karasik.8\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/research.cbc.osu.edu\/karasik.8\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/research.cbc.osu.edu\/karasik.8\/index.php\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/research.cbc.osu.edu\/karasik.8\/index.php\/wp-json\/wp\/v2\/comments?post=12"}],"version-history":[{"count":71,"href":"https:\/\/research.cbc.osu.edu\/karasik.8\/index.php\/wp-json\/wp\/v2\/pages\/12\/revisions"}],"predecessor-version":[{"id":125,"href":"https:\/\/research.cbc.osu.edu\/karasik.8\/index.php\/wp-json\/wp\/v2\/pages\/12\/revisions\/125"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/research.cbc.osu.edu\/karasik.8\/index.php\/wp-json\/wp\/v2\/media\/14"}],"wp:attachment":[{"href":"https:\/\/research.cbc.osu.edu\/karasik.8\/index.php\/wp-json\/wp\/v2\/media?parent=12"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}