Thomas J. Magliery

Office 226 CBEC, 151 W. Woodruff Ave. Office phone +1 (614) 247-8425 magliery.1@osu.edu	ADMINISTRATIVE ASSISTANT Susan Krumm Phone +1 (614) 247-6348 skrumm@chemistry.ohio-state.edu
mailing address Department of Chemistry & Biochemistry The Ohio State University 100 W. 18th Ave. Columbus, OH 43210	Lab/COURIER Magliery Lab / 390 CBEC The Ohio State University 151 W. Woodruff Ave. Columbus, OH 43210 Lab phone +1 (614) 247-8882

Biography

Thomas J. Magliery was born in Chicago in 1974 and grew up outside of Chicago and Indianapolis. He conducted medical genetics research with M. Ed Hodes at the Indiana University Medical Center in Indianapolis, leading to a semifinalist-winning project in the Westinghouse Science Search in 1992. Magliery majored in chemistry at Kenyon College in Gambier, Ohio, graduating in 1996. There he conducted research in molecular biology and bioinorganic chemistry. His honors thesis work with Rosemary Marusak involved the synthesis of diimides related to EDTA and investigation of the role of their iron-chelate hydrolysis products in hydoxyl-radical damage of DNA. In 1994, he spent a summer at Penn State University with Gordon Hamilton as an NSF REU fellow working towards the synthesis of a putative intermediate in the conversion of ascorbic acid to S-oxalins. Magliery graduated with highest honors in chemistry, distinction on the senior exercise in chemistry, summa cum laude and with election to Phi Beta Kappa and Sigma Xi.

Magliery received his Ph.D. (2001) in chemistry from the University of California, Berkeley, under the direction of Peter G. Schultz. As an NSF Pre-Doctoral Fellow, he worked on several key aspects of engineering living bacteria for the site-specific insertion of unnatural amino acids, including: engineering the first “orthogonal” tRNA and aminoacyl-tRNA synthetase for use in E. coli; development of library and selection technology that led to the first bacteria with expanded genetic codes; and selection and characterization of tRNAs capable of decoding 4-base codons. He moved to The Scripps Research Institute in La Jolla, California, with Schultz in 1999.

With Lynne Regan in Molecular Biophysics & Biochemistry at Yale University in 2001, Magliery introduced a cell-based screen for the four-helix bundle protein Rop and demonstrated its use in sorting libraries of protein variants with randomized hydrophobic cores. He expanded a GFP fragment reassembly screen for the detection of protein-protein interactions in bacteria, screening for antiparallel leucine zipper interactions and investigating kinetic aspects of GFP fragment reassembly. He also used a statistical free energy approach to improve the design of “consensus” tetratricopeptide repeat (TPR) motifs, discovering in the process how sequence variation can be used to understand and predict ligand binding sites in proteins. Magliery was an NIH Postdoctoral Fellow.

Magliery joined the faculty of The Ohio State University in the fall of 2005 in the Departments of Chemistry and Biochemistry, and he was promoted to Associate Professor in the merged Department of Chemistry & Biochemistry in 2013. He is a member of the graduate faculty of the Chemistry Ph.D. program, the Ohio State Biochemistry Program (OSBP), the Biophysics Graduate Program, and the Microbiology Graduate Program. Magliery’s research interest is in the application of combinatorial, high-throughput and statistical methods to understanding the relationship between protein sequence and stability, as well as other biophysical properties. He also uses protein engineering techniques to improve the properties of proteins as therapeutic and diagnostic agents. Read more on the research page.

In 2013, Magliery became the Director of OSBP, and served until he became the Vice Chair for Graduate Studies for the Department of Chemistry & Biochemistry in January, 2017. He has focused his time as a graduate studies chair on issues related to strengthening mentoring systems and responsibility, career and professional development, and diversity. Since 2017, he has been a founding co-director of the NIH T32 Molecular Biophysics Training Program (MBTP), and he is also a trainer in the Cellular, Molecular, and Biochemical Sciences Training Program (CMBP), and was a trainer in the Chemistry-Biology Interface Training Program (CBIP) until the program ended in 2017. In 2017, Magliery led an effort to found a summer research program for students from the Ohio Five liberal arts schools at Ohio State, and the Summer Undergraduate Research Experience (Ohio5-SURE) hosted its first class in the summer of 2018 in the Department of Chemistry & Biochemistry.

Magliery is the Chief Scientific Officer at Enlyton, Ltd., a start-up company focused on cancer imaging, using intellectual property from his lab. He completed an M.B.A. in the summer of 2018 from the Fisher College of Business at Ohio State, with emphasis on leadership and entrepreneurship.

Biosketch

Education and Training

• A.B., Kenyon College, Gambier, Ohio, 1996, Chemistry (Rosemark Marusak)
• Ph.D., University of California, Berkeley, 2001, Chemistry (Peter G. Schultz)
• Graduate Research, The Scripps Research Institute, La Jolla, California, 1999-2001 (Peter G. Schultz)
• NIH Postdoctoral Fellow, Yale University, New Haven, Connecticut, 2001-2005, Molecular Biophysics & Biochemistry (Lynne Regan)
• M.B.A., The Ohio State University – Fisher College of Business, Columbus, 2018, Entrepreneurship and Leadership

Positions

2017 – present, Co-Director, Molecular Biophysics Training Program (NIH T32)
2017 – present, Vice Chair, Graduate Studies, Dept. of Chemistry & Biochemistry
2016 – present, Chief Scientific Officer, Enlyton, Ltd.
2013 – 2016, Director and Graduate Studies Committee Chair, Ohio State Biochemistry Program
2013 – present, Associate Professor, Chemistry & Biochemistry, The Ohio State University, Columbus
2005 – 2013, Assistant Professor, Chemistry and Biochemistry, The Ohio State University, Columbus

Faculty: Ohio State Biochemistry Program (2005-present), Biophysics Graduate Program (2005-present), and Microbiology Graduate Program (2012-present). Faculty Trainer: Chemistry-Biology Interface Training Program (2006-2017) and Cellular, Molecular and Biochemical Sciences Training Program (2011-present); Molecular Biophysics Training Program (2017-present).

Other Experience

2017 – present, Faculty Director, Ohio Five Summer Undergraduate Research Experience at The Ohio State University
2017 – present, Faculty Advisor, ChemTALKS
2017 – 2018, Search Committee, Graduate School Dean, Ohio State University
2017, Associate Member, Committee on Professional Training, American Chemical Society
2014 – 2018, Ad hoc reviewer for NIH BCMB SEP
2014 – 2016, Councilor, American Chemical Society, Biological Division
2013 – 2014, Ad hoc reviewer for NIH IMST 10 SBIR/STTR study section
2013 – 2015, Member, Nominating Committee, Protein Society
2012, Chair, Local Organizing Committee, Fifth International Symposium on Paraoxonases (5PON), July 15-18, The Ohio State University, Columbus, Ohio
2010 – 2013, Ad hoc reviewer for NIH CounterACT study sections (U01/U54 and R21)
2008 – 2017, Member, Editorial Advisory Board, Molecular BioSystems
2005 – 2008, Board of Directors, Sigma Xi, Ohio State Chapter

Professional Development

2018, National Research Mentoring Network-CIC Academic Network, Facilitating Research Mentor Training
2016, Participant, Advocates and Allies
2012, Rosetta Workshop, Meiler Lab, Vanderbilt University
2007, X-Ray Methods in Structural Biology, Cold Spring Harbor Laboratory, New York
2003, Biomolecular NMR Spectroscopy, Varian Training Course

Honors

2015, Finalist, College of Arts & Sciences Outstanding Teaching Award, OSU
2014, Elizabeth L. Gross Faculty Award, Biophysics Graduate Program, OSU
2011, James M. Siddens Award for Distinguished Faculty Advising, OSU
2008, Finalist, Distinguished Undergraduate Research Mentor of the Year Award, OSU
2006, Finalist, College of Arts & Sciences Outstanding Teaching Award, OSU
2002-2005, NIH Postdoctoral Fellowship, NRSA F32, NIGMS
1997-2000, NSF Predoctoral Fellowship
1996, Carl Djerassi Award in Chemistry, Kenyon College
1996, Sigma Xi
1995, Phi Beta Kappa
1995, Barry Goldwater Scholarship

Publications

See the publications page.

Teaching

See the teaching page.