{"id":8,"date":"2018-07-21T15:59:33","date_gmt":"2018-07-21T19:59:33","guid":{"rendered":"https:\/\/research.cbc.osu.edu\/magliery.1\/?page_id=8"},"modified":"2018-09-17T09:49:36","modified_gmt":"2018-09-17T13:49:36","slug":"thomas-j-magliery","status":"publish","type":"page","link":"https:\/\/research.cbc.osu.edu\/magliery.1\/thomas-j-magliery\/","title":{"rendered":"Thomas J. Magliery"},"content":{"rendered":"\n\n\n\n\t\n\t
Office<\/h5>
\n226 CBEC, 151 W. Woodruff Ave.<\/a>
\nOffice phone +1 (614) 247-8425
\nmagliery.1@osu.edu<\/a><\/td>
ADMINISTRATIVE ASSISTANT<\/h5>
\nSusan Krumm
\nPhone +1 (614) 247-6348
\nskrumm@chemistry.ohio-state.edu<\/a><\/td>\n<\/tr>\n
mailing address<\/h5>
\nDepartment of Chemistry & Biochemistry
\nThe Ohio State University
\n100 W. 18th Ave.
\nColumbus, OH 43210<\/td>
Lab\/COURIER<\/h5>
\nMagliery Lab \/ 390 CBEC
\nThe Ohio State University
\n151 W. Woodruff Ave.
\nColumbus, OH 43210
\nLab phone +1 (614) 247-8882<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n

Biography<\/h4>\n

\"\"<\/p>\n

Thomas J. Magliery was born in Chicago in 1974 and grew up outside of Chicago and Indianapolis. He conducted medical genetics research with M. Ed Hodes at the Indiana University Medical Center in Indianapolis, leading to a semifinalist-winning project in the Westinghouse Science Search in 1992. Magliery majored in chemistry at Kenyon College in Gambier, Ohio, graduating in 1996. There he conducted research in molecular biology and bioinorganic chemistry. His honors thesis work with Rosemary Marusak involved the synthesis of diimides related to EDTA and investigation of the role of their iron-chelate hydrolysis products in hydoxyl-radical damage of DNA. In 1994, he spent a summer at Penn State University with Gordon Hamilton as an NSF REU fellow working towards the synthesis of a putative intermediate in the conversion of ascorbic acid to S-oxalins. Magliery graduated with highest honors in chemistry, distinction on the senior exercise in chemistry, summa cum laude and with election to Phi Beta Kappa and Sigma Xi.<\/p>\n

Magliery received his Ph.D. (2001) in chemistry from the University of California, Berkeley, under the direction of Peter G. Schultz. As an NSF Pre-Doctoral Fellow, he worked on several key aspects of engineering living bacteria for the site-specific insertion of unnatural amino acids, including: engineering the first “orthogonal” tRNA and aminoacyl-tRNA synthetase for use in E. coli; development of library and selection technology that led to the first bacteria with expanded genetic codes; and selection and characterization of tRNAs capable of decoding 4-base codons. He moved to The Scripps Research Institute in La Jolla, California, with Schultz in 1999.<\/p>\n

With Lynne Regan in Molecular Biophysics & Biochemistry at Yale University in 2001, Magliery introduced a cell-based screen for the four-helix bundle protein Rop and demonstrated its use in sorting libraries of protein variants with randomized hydrophobic cores. He expanded a GFP fragment reassembly screen for the detection of protein-protein interactions in bacteria, screening for antiparallel leucine zipper interactions and investigating kinetic aspects of GFP fragment reassembly. He also used a statistical free energy approach to improve the design of “consensus” tetratricopeptide repeat (TPR) motifs, discovering in the process how sequence variation can be used to understand and predict ligand binding sites in proteins. Magliery was an NIH Postdoctoral Fellow.<\/p>\n

Magliery joined the faculty of The Ohio State University in the fall of 2005 in the Departments of Chemistry and Biochemistry, and he was promoted to Associate Professor in the merged Department of Chemistry & Biochemistry in 2013. He is a member of the graduate faculty of the Chemistry Ph.D. program, the Ohio State Biochemistry Program (OSBP), the Biophysics Graduate Program, and the Microbiology Graduate Program.\u00a0Magliery\u2019s research interest is in the application of combinatorial, high-throughput and statistical methods to understanding the relationship between protein sequence and stability, as well as other biophysical properties. He also uses protein engineering techniques to improve the properties of proteins as therapeutic and diagnostic agents. Read more on the research page.<\/a><\/p>\n

In 2013, Magliery became the Director of OSBP, and served until he became the Vice Chair for Graduate Studies for the Department of Chemistry & Biochemistry in January, 2017.\u00a0He has focused his time as a graduate studies chair on issues related to strengthening mentoring systems and responsibility, career and professional development, and diversity. Since 2017, he has been a founding co-director of the NIH T32 Molecular Biophysics Training Program (MBTP), and he is also a trainer in the Cellular, Molecular, and Biochemical Sciences Training Program (CMBP), and was a trainer in the Chemistry-Biology Interface Training Program (CBIP) until the program ended in 2017. In 2017, Magliery led an effort to found a summer research program for students from the Ohio Five liberal arts schools at Ohio State, and the Summer Undergraduate Research Experience (Ohio5-SURE) hosted its first class in the summer of 2018 in the Department of Chemistry & Biochemistry.<\/p>\n

Magliery is the Chief Scientific Officer at Enlyton, Ltd., a start-up company focused on cancer imaging, using intellectual property from his lab. He completed an M.B.A. in the summer of 2018 from the Fisher College of Business at Ohio State, with emphasis on leadership and entrepreneurship.<\/p>\n

Biosketch<\/h4>\n
Education and Training<\/h5>\n