{"id":237,"date":"2015-02-23T19:51:11","date_gmt":"2015-02-24T00:51:11","guid":{"rendered":"https:\/\/research.cbc.osu.edu\/pei.3\/?page_id=237"},"modified":"2018-12-05T01:07:32","modified_gmt":"2018-12-05T06:07:32","slug":"previous-publications","status":"publish","type":"page","link":"https:\/\/research.cbc.osu.edu\/pei.3\/publications\/previous-publications\/","title":{"rendered":"Previous Publications"},"content":{"rendered":"

Years 2011-2012 <\/span><\/h2>\n

109. Kunys AR; Lian W; Pei D. Specificity profiling of protein-binding domains using one-bead-one-compound Peptide libraries. Curr. Protoc. Chem Biol.<\/em> 2012 Dec 1;4<\/em>(4):331-55.<\/span><\/p>\n

108. Dewan V, Liu T, Chen KM, Qian Z, Xiao Y, Kleiman L, Mahasenan KV, Li C, Matsuo H, Pei D, Musier-Forsyth K. Cyclic Peptide Inhibitors of HIV-1 Capsid-Human Lysyl-tRNA Synthetase Interaction. ACS Chem Biol<\/em><\/span>.<\/em> ACS Chem. Biol.<\/em> 2012 Apr 20;7<\/em>(4):761-9<\/span><\/p>\n

107. Malladi VL, Sobczak AJ, Meyer TM, Pei D, Wnuk SF. Inhibition of LuxS by S-ribosylhomocysteine analogues containing a [4-aza]ribose ring. Bioorg Med Chem<\/em><\/span>.<\/em> 2011 Sep 15;19<\/em>(18):5507-19.<\/span><\/p>\n

106. Liu, Tao; Qian, Ziqing; Xiao, Qing; Pei, Dehua. High-Throughput Screening of One-Bead-One-Compound Libraries: Identification of Cyclic Peptidyl Inhibitors against Calcineurin\/NFAT Interaction. ACS Combinatorial Science<\/em> \u00a0(2011), 13<\/em>(5),\u00a0537-546.<\/span><\/p>\n

105. Xianghong Wu, Lisheng Wang, Yaohua Han, Nicholas Regan, Pui-Kai Li, Miguel A. Villalona, Xiche Hu, Roger Briesewitz, and Dehua Pei. Creating Diverse Target-Binding Surfaces on FKBP12: Synthesis and<\/span>
\n Evaluation of a Rapamycin Analogue Library. ACS Comb. Sci.<\/cite>, <\/span>2011<\/strong>, 13<\/em> (5), pp 486\u2013495<\/span><\/p>\n

104. Zhang, Yanyan; Zhang Jinjin; Yuan, Chunhua; Hard, Ryan L.; Park, In-Hee; Li, Chenlong; Bell, Charles; Pei, Dehua. Simultaneous Binding of Two Peptidyl Ligands by a Src Homology 2 Domain. Biochemistry\u00a0(2011),\u00a050(35),\u00a07637-7646.,<\/span><\/p>\n

103. Ren, Lige; Chen, Xianwen; Luechapanichkul, Rinrada; Selner, Nicholas G.; Meyer, Tiffany M.; Wavreille, Anne-Sophie; Chan, Richard; Iorio, Caterina; Zhou, Xiang; Neel, Benjamin G.; et al. Substrate Specificity of Protein Tyrosine Phosphatases 1B, RPTP\u03b1, SHP- 1, and SHP- 2. <\/span>Biochemistry<\/cite><\/em>, 2011<\/span>, 50<\/span> (12), pp 2339\u20132356<\/span><\/p>\n

102. Shepherd, Tyson R.; Hard, Ryan L.; Murray, Ann M.; Pei, Dehua; Fuentes, Ernesto J. Distinct Ligand Specificity of the Tiam1 and Tiam2 PDZ Domains. Biochemistry\u00a0(2011),\u00a050(8),\u00a01296-1308.<\/span><\/p>\n

101. Plummer, Paul; Zhu, Jinge; Akiba, Masato; Pei, Dehua; Zhang, Qijing. Identification of a key amino acid of LuxS involved in AI- 2 production in Campylobacter jejuni. PLoS One\u00a0(2011),\u00a06(1),\u00a0e15876<\/span><\/p>\n

\n

<\/a>Years 2009-2010 <\/span><\/span><\/h2>\n

100. Hard, Ryan L.; Liu, Jiangxin; Shen, Juan; Zhou, Pei; Pei, Dehua. HDAC6 and Ubp-M BUZ Domains Recognize Specific C-Terminal Sequences of Proteins. Biochemistry (2010), 49(50), 10737-10746<\/span><\/p>\n

99. Chen, Xianwen; Ren, Lige; Kim, Soochong; Carpino, Nicholas; Daniel, James L.; Kunapuli, Satya P.; Tsygankov, Alexander Y.; Pei, Dehua. Determination of the Substrate Specificity of Protein-tyrosine Phosphatase TULA-2 and Identification of Syk as a TULA-2 Substrate. Journal of Biological Chemistry (2010), 285(41), 31268-31276<\/span><\/p>\n

98. Xiao, Qing; Zhang, Feiran; Nacev, Benjamin A.; Liu, Jun O.; Pei, Dehua. Protein N-Terminal Processing: Substrate Specificity of Escherichia coli and Human Methionine Aminopeptidases. Biochemistry (2010), 49(26), 5588-5599.<\/span><\/p>\n

97. Liu, Tao; Liu, Yu; Kao, Hung-Ying; Pei, Dehua. Membrane Permeable Cyclic Peptidyl Inhibitors against Human Peptidylprolyl Isomerase Pin1. Journal of Medicinal Chemistry (2010), 53(6), 2494-2501.<\/span><\/p>\n

96. Pei, Dehua. On-Bead Library Screening Made Easier. Chemistry & Biology (2010), 17(1), 3-4<\/span><\/p>\n

95. Zhang, Yanyan; Wavreille, Anne-Sophie; Kunys, Andrew R.; Pei, Dehua. The SH2 Domains of Inositol Polyphosphate 5-Phosphatases SHIP1 and SHIP2 Have Similar Ligand Specificity but Different Binding Kinetics. Biochemistry (2009), 48(46), 11075-11083.<\/span><\/p>\n

94. Wnuk, Stanislaw F.; Robert, Jenay; Sobczak, Adam J.; Meyers, Brandon P.; Malladi, Venkata L. A.; Zhu, Jinge; Gopishetty, Bhaskar; Pei, Dehua. Inhibition of S-ribosylhomocysteinase (LuxS) by substrate analogues modified at the ribosyl C-3 position. Bioorganic & Medicinal Chemistry (2009), 17(18), 6699-6706.<\/span><\/p>\n

93. Ekici, Ozlem Dogan; Zhu, Jinge; Wah Chung, Ivy Yeuk; Paetzel, Mark; Dalbey, Ross E.; Pei, Dehua. Profiling the Substrate Specificity of Viral Protease VP4 by a FRET-Based Peptide Library Approach. Biochemistry<\/em> (2009), 48<\/em>(24), 5753-5759.a<\/span><\/p>\n

92. Chen, Xianwen; Tan, Pauline H.; Zhang, Yanyan; Pei, Dehua. On-Bead Screening of Combinatorial Libraries: Reduction of Nonspecific Binding by Decreasing Surface Ligand Density. Journal of Combinatorial Chemistry<\/em> (2009), 11(4), 604-611.<\/span><\/p>\n

91. Liu, Tao; Joo, Sang Hoon; Voorhees, Jeffrey L.; Brooks, Charles L.; Pei, Dehua. Synthesis and screening of a cyclic peptide library: Discovery of small-molecule ligands against human prolactin receptor. Bioorganic & Medicinal Chemistry<\/em> (2009), 17<\/em>(3), 1026-1033.<\/span><\/p>\n

90. Thakkar, Amit; Cohen, Allison S.; Connolly, Michael D.; Zuckermann, Ronald N.; Pei, Dehua. High-Throughput Sequencing of Peptoids and Peptide-Peptoid Hybrids by Partial Edman Degradation and Mass Spectrometry. Journal of Combinatorial Chemistry<\/em> (2009), 11(2), 294-302.<\/span><\/p>\n

89. Gopishetty, Bhaskar; Zhu, Jinge; Rajan, Rakhi; Sobczak, Adam J.; Wnuk, Stanislaw F.; Bell, Charles E.; Pei, Dehua. Probing the Catalytic Mechanism of S-Ribosylhomocysteinase (LuxS) with Catalytic Intermediates and Substrate Analogues. Journal of the American Chemical Society<\/em> (2009), 131<\/em>(3), 1243-1250.<\/span><\/p>\n<\/div>\n

\n

<\/a>Years 2007-2008<\/span><\/span><\/h2>\n

88. Gopishetty, Bhaskar; Ren, Lige, Waller, Tiffany M.; Wavreille, Anne-Sophie; Lopez, Miguel; Thakkar, Amit; Zhu, Jinge; Pei, Dehua. Synthesis of 3,5-Difluorotyrosine-Containing Peptides: Application in Substrate Profiling of Protein Tyrosine Phosphatases. Organic Letters<\/em> (2008), 10<\/em>(20), 4605-4608.<\/span><\/p>\n

87. Shen, Gang; Zhu, Jinge; Simpson, Anthony M.; Pei, Dehua. Design and synthesis of macrocyclic peptidyl hydroxamates as peptide deformylase inhibitors. Bioorganic & Medicinal Chemistry Letters<\/em> (2008), 18<\/em>(10), 3060-3063.<\/span><\/p>\n

86. Wnuk, Stanislaw F.; Lalama, Jennifer; Garmendia, Craig A.; Robert, Jenay; Zhu, Jinge; Pei, Dehua. S-Ribosylhomocysteine analogues with the carbon-5 and sulfur atoms replaced by a vinyl or (fluoro)vinyl unit. Bioorganic & Medicinal Chemistry<\/em> (2008), 16<\/em>(9), 5090-5102.<\/span><\/p>\n

85. Zhang, Yanyan; Zhou, Shanggen; Wavreille, Anne-Sophie; DeWille, James; Pei, Dehua. Cyclic Peptidyl Inhibitors of Grb2 and Tensin SH2 Domains Identified from Combinatorial Libraries. Journal of Combinatorial Chemistry<\/em> (2008), 10<\/em>(2), 247-255.<\/span><\/p>\n

84. Nguyen, Kiet T.; Pei, Dehua. High-throughput screening of peptide deformylase inhibitors. Methods in Molecular Medicine<\/em> (2008), 142<\/em> (New Antibiotic Targets), 117-130.<\/span><\/p>\n

83. Joo, Sang Hoon; Pei, Dehua. Synthesis and Screening of Support-Bound Combinatorial Peptide Libraries with Free C-Termini: Determination of the Sequence Specificity of PDZ Domains. Biochemistry<\/em> (2008), 47<\/em>(9), 3061-3072.<\/span><\/p>\n

82. Zhu, Jinge; Pei, Dehua. A LuxP-Based Fluorescent Sensor for Bacterial Autoinducer II. ACS Chemical Biology<\/em> (2008), 3<\/em>(2), 110-119.<\/span><\/p>\n

81. Nguyen, Kiet T.; Wu, Jen-Chieh; Boylan, Julie A.; Gherardini, Frank C.; Pei, Dehua. Zinc is the metal cofactor of Borrelia burgdorferi peptide deformylase. Archives of Biochemistry and Biophysics<\/em> (2007), 468<\/em>(2), 217-225.<\/span><\/p>\n

80. Pei, Dehua; Wavreille, Anne-Sophie. Reverse interactomics: decoding protein-protein interactions with combinatorial peptide libraries. Molecular BioSystems<\/em> (2007), 3<\/em>(8), 536-541.<\/span><\/p>\n

79. Xiao, Qing; Pei, Dehua. High-Throughput Synthesis and Screening of Cyclic Peptide Antibiotics. Journal of Medicinal Chemistry<\/em> (2007), 50<\/em>(13), 3132-3137.<\/span><\/p>\n

78. Wavreille, Anne-Sophie; Garaud, Mathieu; Zhang, Yanyan; Pei, Dehua. Defining SH2 domain and PTP specificity by screening combinatorial peptide libraries. Methods<\/em> (Oxford, United Kingdom) (2007), 42<\/em>(3), 207-219.<\/span><\/p>\n

77. Garaud, Mathieu; Pei, Dehua. Substrate Profiling of Protein Tyrosine Phosphatase PTP1B by Screening a Combinatorial Peptide Library. Journal of the American Chemical Society<\/em> (2007), 129<\/em>(17), 5366-5367.<\/span><\/p>\n

76. Rajamani, Sathish; Zhu, Jinge; Pei, Dehua; Sayre, Richard. A LuxP-FRET-Based Reporter for the Detection and Quantification of AI-2 Bacterial Quorum-Sensing Signal Compounds. Biochemistry<\/em> (2007), 46<\/em>(13), 3990-3997.<\/span><\/p>\n

75. Wavreille, Anne-Sophie; Pei, Dehua. A Chemical Approach to the Identification of Tensin-Binding Proteins. ACS Chemical Biology<\/em> (2007), 2<\/em>(2), 109-118.<\/span><\/p>\n

74. Ekici, Ozlem Dogan; Karla, Andrew; Paetzel, Mark; Lively, Mark O.; Pei, Dehua; Dalbey, Ross E. Altered -3 Substrate Specificity of Escherichia coli Signal Peptidase 1 Mutants as Revealed by Screening a Combinatorial Peptide Library. Journal of Biological Chemistry<\/em> (2007), 282<\/em>(1), 417-425.<\/span><\/p>\n

 <\/p>\n<\/div>\n

\n

<\/a>Years 2005-2006<\/h2>\n

73. Sweeney, Michael C.; Wang, Xianxi; Park, Junguk; Liu, Yusen; Pei, Dehua. Determination of the Sequence Specificity of XIAP BIR Domains by Screening a Combinatorial Peptide Library. Biochemistry<\/em> (2006), 45<\/em>(49), 14740-14748.<\/span><\/p>\n

72. Zhu, Jinge; Knottenbelt, Sushilla; Kirk, Martin L.; Pei, Dehua. Catalytic Mechanism of S-Ribosylhomocysteinase: Ionization State of Active-Site Residues. Biochemistry<\/em> (2006), 45<\/em>(40), 12195-12203.<\/span><\/p>\n

71. Joo, Sang Hoon; Xiao, Qing; Ling, Yun; Gopishetty, Bhaskar; Pei, Dehua. High-Throughput Sequence Determination of Cyclic Peptide Library Members by Partial Edman Degradation\/Mass Spectrometry. Journal of the American Chemical Society<\/em> (2006), 128<\/em>(39), 13000-13009.<\/span><\/p>\n

70. Imhof, Diana; Wavreille, Anne-Sophie; May, Andreas; Zacharias, Martin; Tridandapani, Susheela; Pei, Dehua. Sequence Specificity of SHP-1 and SHP-2 Src Homology 2 Domains. Critical Roles of Residues Beyond the pY+3 Position. Journal of Biological Chemistry<\/em> (2006), 281<\/em>(29), 20271-20282.<\/span><\/p>\n

69. Thakkar, Amit; Wavreille, Anne-Sophie; Pei, Dehua. Traceless Capping Agent for Peptide Sequencing by Partial Edman Degradation and Mass Spectrometry. Analytical Chemistry<\/em> (2006), 78<\/em>(16), 5935-5939.<\/span><\/p>\n

68. Wang, Xianxi; Matta, Ranyia; Shen, Gang; Nelin, Leif D.; Pei, Dehua; Liu, Yusen. Mechanism of triptolide-induced apoptosis: effect on caspase activation and Bid cleavage and essentiality of the hydroxyl group of triptolide. Journal of Molecular Medicine<\/em> ( Heidelberg, Germany) (2006), 84<\/em>(5), 405-415.<\/span><\/p>\n

67. Shen, Gang; Rajan, Rakhi; Zhu, Jinge; Bell, Charles E.; Pei, Dehua. Design and Synthesis of Substrate and Intermediate Analogue Inhibitors of S-Ribosylhomocysteinase. Journal of Medicinal Chemistry<\/em> (2006), 49<\/em>(10), 3003-3011.<\/span><\/p>\n

66. Sweeney, Michael C.; Wavreille, Anne-Sophie; Park, Junguk; Butchar, Jonathan P.; Tridandapani, Susheela; Pei, Dehua. Decoding Protein-Protein Interactions through Combinatorial Chemistry: Sequence Specificity of SHP-1, SHP-2, and SHIP SH2 Domains. Biochemistry<\/em> (2005), 44<\/em>(45), 14932-14947.<\/span><\/p>\n

65. Qin, Chuanguang; Wavreille, Anne-Sophie; Pei, Dehua. Alternative Mode of Binding to Phosphotyrosyl Peptides by Src Homology-2 Domains. Biochemistry<\/em> (2005), 44<\/em>(36), 12196-12202.<\/span><\/p>\n

64. Nguyen, Kiet T.; Pei, Dehua. Purification and Characterization of Enzymes Involved in the Degradation of Chemotactic N-Formyl Peptides. Biochemistry<\/em> (2005), 44<\/em>(23), 8514-8522.<\/span><\/p>\n

63. Rajan, Rakhi; Zhu, Jinge; Hu, Xubo; Pei, Dehua; Bell, Charles E. Crystal Structure of S-Ribosylhomocysteinase (LuxS) in Complex with a Catalytic 2-Ketone Intermediate. Biochemistry<\/em> (2005), 44<\/em>(10), 3745-3753.<\/span><\/p>\n<\/div>\n

\n

<\/a>Years 2003-2004<\/h2>\n

62. Zhu, J., Dhimitruka, I., and Pei, D. (2004) 5-(2-Aminoethyl)-dithio-2-nitrobenzoate as a more base-stable alternative to Ellman\u2019s reagent. Org. Lett<\/em>. 6<\/em>, 3809-3812.<\/span><\/p>\n

61. Park, J., and Pei, D. (2004) trans- b -Nitrostyrene derivatives as slow-binding inhibitors of protein tyrosine phosphatases. Biochemistry 43<\/em>, 15014\u201315021.<\/span><\/p>\n

60. Hu, X., Nguyen, K. T., Jiang, V. C., Lofland, D., Moser, H. E., and Pei, D. (2004) Macrocyclic inhibitors for peptide deformylase: An SAR study of the ring size. J. Med. Chem<\/em>. 47<\/em>, 4941\u20134949.<\/span><\/p>\n

59. Zhu, J., Patel, R., and Pei, D. (2004) Catalytic mechanism of S-ribosylhomocysteinase (LuxS): Stereochemical course and kinetic isotope effect of proton transfer reactions. Biochemistry 43<\/em>, 10166\u201310172.<\/span><\/p>\n

58. Pei , D, and Zhu, J. (2004) Mechanism of S-ribosylhomocysteinase (LuxS). Curr. Opin. Chem. Biol<\/em>. 8<\/em>, 492\u2013497.<\/span><\/p>\n

57. Nguyen, K. T., Hu, X., and Pei , D. (2004) Slow-binding inhibition of peptide deformylase by cyclic peptidomimetics as revealed by a new spectrophotometric assay. Bioorg. Chem<\/em>. 32<\/em>, 178\u2013191.<\/span><\/p>\n

56. Robien, M. A., Nguyen, K. T., Kumar, A., Hirsch, I., Turley, S., Pei, D., and Hol, W. G. J. (2004) An Improved crystal form of Plasmodium falciparum peptide deformylase. Protein Sci. 13<\/em>, 1155\u20131163.<\/span><\/p>\n

55. Park, J, Fu, H., and Pei, D. (2004) Peptidyl aldehydes as slow-binding inhibitors of dual-specificity phosphatases. Bioorg. Med. Chem. Lett. 14<\/em>, 685\u2013687.<\/span><\/p>\n

54. Xian, M., Fatima, Z., Zhang, W., Fang, J., Pei, D., Loo, J., Stevenson, T., and Wang, P. G. (2004) Identification of a -Galactosyl Epitope Mimetics through Rapid Generation and Screening of C-linked Combinatorial Glycopeptide Library. J. Comb. Chem. 6<\/em>, 126\u2013134.<\/span><\/p>\n

53. Hu, X., Zhu, J., Srivathsan, S., and Pei, D. (2004) Peptidyl Hydroxamic Acids as Methionine Aminopeptidase Inhibitors. Bioorg. Med. Chem. Lett. 14, <\/em>77\u201379.<\/span><\/p>\n

52. Zhu, J., Hu, X., Dizin, E., and Pei, D. (2003) Catalytic Mechanism of S-Ribosylhomocysteinase (LuxS): Direct Observation of Ketone Intermediates by 13C NMR Spectroscopy. J. Am. Chem. Soc<\/em>. 125<\/em>, 13379\u201313381.<\/span><\/p>\n

51. Hu, X., Nguyen, K. T., Verlinde, C. L. M. J., Hol, W. G. J., and Pei, D. (2003) Structure-based design of a macrocyclic Inhibitor for peptide deformylase. J. Med. Chem<\/em>. 46,<\/em> 3771\u20133774.<\/span><\/p>\n

50. Nguyen, K. T., Hu, X., Colton, C., Chakrabarti, R., Zhu, M. X., and Pei, D. (2003) Characterization of a human peptide deformylase: Implications for antibacterial drug design. Biochemistry 42,<\/em> 9952\u20139958.<\/span><\/p>\n

49. Sweeney, M. C., & Pei, D. (2003) An Improved Method for Rapid Sequencing of Support-Bound Peptides by Partial Edman Degradation and Mass Spectrometry. J. Comb. Chem<\/em>. 5<\/em>, 218\u2013222.<\/span><\/p>\n

48. Zhu, J., Dizin, E., Hu, X., Wavreille, A.-S., Park, J., & Pei, D. (2003) S-Ribosylhomocysteinase (LuxS) is a Mononuclear Iron Protein. Biochemistry 42<\/em>, 4717\u20134726.<\/span><\/p>\n

47. Park, J., Fu, H., & Pei, D. (2003) Peptidyl Aldehydes as Reversible Covalent Inhibitors of Src Homology 2 Domains. Biochemistry 42<\/em>, 5159\u20135167.<\/span><\/p>\n<\/div>\n

\n

<\/a>Years 2001-2002<\/h2>\n

46. Arabaci, G., Yi, T., Fu, H., Porter, M. E., Beebe, K. D., & Pei, D. (2002) a -Bromoacetophenone Derivatives As Neutral Protein Tyrosine Phosphatase Inhibitors: Structure-Function Relationship. Bioorg. Med. Chem. Lett. 12, <\/em>3047\u20133050.<\/span><\/p>\n

45. Deng, H., Callender, R., Zhu, J., Nguyen, K. T., & Pei, D. (2002) Determination of the Ionization State and Catalytic Function of Glu-133 in Peptide Deformylase by Difference FTIR Spectroscopy. Biochemistry<\/em> 41<\/em>, 10563\u201310569.<\/span><\/p>\n

44. Fu, H., Park, J., & Pei, D. (2002) Peptidyl Aldehydes as Reversible Covalent Inhibitors of Protein Tyrosine Phosphatases. Biochemistry<\/em> 41, 10700\u201310709.<\/span><\/p>\n

43. Wang, P., Fu, H., Snavley, D. F., Freitas, M. A., & Pei, D. (2002) Screening Combinatorial Libraries by Mass Spectrometry. 2. Identification of Optimal Substrates of Protein Tyrosine Phosphatase SHP-1. Biochemistry 41<\/em>, 6202\u20136210.<\/span><\/p>\n

42. Kumar, A., Nguyen, K. T., Srivathsan, S., Ornstein, B., Turley, S., Hirsch, I., Pei, D., & Hol, W. G. J. (2002) Crystals of Peptide Deformylase from Plasmodium falciparum<\/em> Reveal Critical Characteristics of the Active Site for Drug Design. Structure 10<\/em>, 357\u2013367.<\/span><\/p>\n

41. Bracchi-Ricard, V., Nguyen, K. T., Zhou, Y., Rajagopalan, P. T. R., Chakrabarti, D., and Pei, D. (2001) Characterization of an Eukaryotic Peptide Deformylase from Plasmodium falciparum<\/em>. Arch. Biochem. Biophys. 396<\/em>, 162\u2013170.<\/span><\/p>\n

40. Wang, P., Snavley, D. F., Freitas, M. A., & Pei, D. (2001) Screening Combinatorial Libraries for Optimal Enzyme Substrates by Mass Spectrometry. Rapid Commun. Mass Spectrom<\/em>., 2001<\/em>, 15<\/em>, 1166\u20131171.<\/span><\/p>\n

39. Wang, P., Arabaci, G., & Pei, D. (2001) Rapid Sequencing of Library Derived Peptides by Partial Edman Degradation and Mass Spectrometry. J. Comb. Chem. 3<\/em>, 251\u2013254.<\/span><\/p>\n

38. Pei, D. (2001) Peptide Deformylase: A Target for Novel Antibiotics? Emerging Therapeutic Targets 5<\/em>, 23\u201340.<\/span><\/p>\n<\/div>\n

\n

<\/a>Years 1989-2000<\/h2>\n

37. Liao, H., Yuan, C., Su, M.-I., Yongkiettrakul, S., Qin, D., Li, H., Byeon, I.-J., Pei, D., & Tsai, M.-D. (2000). Structure of the FHA1 domain of yeast Rad53 and identification of binding sites for both FHA1 and its target protein Rad9. J. Mol. Biol.<\/em> 304, 941\u2013951.<\/span><\/p>\n

36. Wang, P., Byeon, I.-J. L., Liao, H., Beebe, K. D., Yongkiettrakul, S., Pei, D., and Tsai, M.-D. (2000). Structure and Specificity of the Interaction between the FHA2 Domain of Rad53 and Phosphotyrosyl Peptides. J. Mol. Biol. <\/em>302, 927\u2013940.<\/span><\/p>\n

35. Beebe, K. D., Wang, P., Arabaci, G., and Pei, D. (2000). Determination of the Binding Specificity of the SH2 Domains of Protein Tyrosine Phosphatase SHP-1 through the Screening of a Combinatorial Phosphotyrosyl Peptide Library. Biochemistry<\/em> 39, 13251\u201313260.<\/span><\/p>\n

34. Wei, Y., Yi, T., Huntington, K. M., Chaudhury, C., and Pei, D. (2000). Identification of Potent Peptide Deformylase Inhibitors from a Rationally Designed Combinatorial Library. J. Comb. Chem.<\/em> 2, 650\u2013657.<\/span>
\n 33. Wei, Y. & Pei, D. (2000). Activation of Antibacterial Prodrugs by Peptide Deformylase. Bioorg. Med. Chem. Lett.<\/em> 10, 1073\u20131076.<\/span><\/p>\n

32. Zhou, Y., Guo, X.-C., Yi, T., Yoshimoto, T., and Pei, D. (2000). Two Continuous Spectrophotometric Assays for Methionine Aminopeptidase. Anal. Biochem.<\/em> 280, 159\u2013165.<\/span><\/p>\n

31. Beebe, K. D., Shin, J., Peng, J., Chaudhury, C., Khera, J., and Pei, D. (2000). Substrate Recognition through a PDZ Domain in Tail Specific Protease. Biochemistry<\/em> 39, 3149\u20133155.<\/span><\/p>\n

30. Huntington, K. M., Yi, T., Wei, Y., and Pei, D. (2000). Synthesis and Antibacterial Activity of Peptide Deformylase Inhibitors. Biochemistry<\/em> 39, 4543\u20134551.<\/span><\/p>\n

29. Rajagopalan, P. T. R., Grimme, S., and Pei, D. (2000). Characterization of Cobalt(II)-Substituted Peptide Deformylase: Function of the Metal Ion and the Catalytic Residue Glu-133. Biochemistry<\/em> 39, 779\u2013790.<\/span><\/p>\n

28. Huntington, K. M., Bienvenue, D. L., Wei, Y., Bennet, B., Holz, R. L., and Pei, D. (1999) Slow-Binding Inhibition of the Aminopeptidase from Aeromonas proteolytica by Peptidyl Thiols: Synthesis and Spectroscopic Characterization. Biochemistry<\/em> 38, 15587\u201315596.<\/span><\/p>\n

27. Guo, X.-C., Rajagopalan, P. T. R., and Pei, D. (1999) A Direct Spectrophotometric Assay for Peptide Deformylase. Anal. Biochem.<\/em> 273, 298\u2013304.<\/span><\/p>\n

26. Arabaci, G., Guo, X.-C., Beebe, K. D., Coggeshall, K. M., and Pei, D. (1999) a-Haloaceto-phenone Derivatives As Photoreversible Covalent Inhibitors of Protein Tyrosine Phosphatases. J. Am. Chem. Soc. <\/em>121, 5085\u20135086.<\/span><\/p>\n

25. Hao, B., Gong, W., Rajagopalan, P. T. R., Zhou, Y., Pei, D., & Chan, M. K. (1999) Structural Basis for the Design of Antibiotics Targeting Peptide Deformylase. Biochemistry<\/em> 38, 4712\u20134719.<\/span><\/p>\n

24. Hu, Y.-J., Wei, Y., Zhou, Y., Rajagopalan, P. T. R., and Pei, D. (1999) Determination of Substrate Specificity for Peptide Deformylase through the Screening of a Combinatorial Peptide Library. Biochemistry<\/em> 38, 643\u2013650.<\/span><\/p>\n

23. Hu, Y.-J., Rajagopalan, P. T. R., & Pei, D. (1998) H-Phosphonate Derivatives as Novel Peptide Deformylase Inhibitors. Bioorg. Med. Chem. Lett.<\/em> 8, 2479-2482.<\/span><\/p>\n

22. Wei, Y., Yan, Y., Pei, D., & Gong, B. (1998) Prodrug Activation by Photolysis. Bioorg. Med. Chem. Lett.<\/em> 8, 2419\u20132422.<\/span><\/p>\n

21. Rajagopalan, P. T. R., and Pei, D. (1998) Oxygen Mediated Inactivation of Peptide Deformylase. J. Biol. Chem.<\/em> 273, 22305-22310.<\/span><\/p>\n

20. Beebe, K. T., & Pei, D. (1998) A Continuous Fluorimetric Assay for Tail Specific Protease. Anal. Biochem.<\/em> 263, 51-56.<\/span><\/p>\n

19. Rajagopalan, P. T. R., Yu, X. C., & Pei, D. (1997) Peptide Deformylase: A New Type of Mononuclear Iron Protein. J. Am. Chem. Soc.<\/em> 119, 12418-12419.<\/span><\/p>\n

18.Chan, M. K., Gong, W., Rajagopalan, P. T. R., Hao, B., Tsai, C. M., & Pei, D. (1997) Crystal Structure of the Escherichia coli Peptide Deformylase. Biochemistry<\/em> 36, 13904-13909.<\/span><\/p>\n

17. Rajagopalan, P. T. R., Datta, A., & Pei, D. (1997) Purification, Characterization, and Inhibition of Peptide Deformylase from Escherichia coli. Biochemistry<\/em> 36, 13910-13918.<\/span><\/p>\n

16. Wei, Y. & Pei, D. (1997) Continuous Spectrophotometric Assay of Peptide Deformylase. Anal. Biochem.<\/em> 250, 29-34.<\/span><\/p>\n

15. Kharbanda, S. M., Bharti, A., Pei, D., Wang, J., Pandey, D., Ren, R., Weichselbaum, R., Walsh, C. T., & Kufe, D. (1996) The Stress Response to Ionizing Radiation Involves c-Abl-Dependent Phosphorylation of SHP-1. Proc. Natl. Acad. Sci. U.S.A.<\/em> 93, 6898-6901.<\/span><\/p>\n

14. Pei, D., Wang, J., & Walsh, C. T. (1996) Differential Functions of the Two Src Homology 2 Domains in Protein Tyrosine Phosphatase SH-PTP1. Proc. Natl. Acad. Sci. USA 93, 1141-1145.<\/span><\/p>\n

13. Payne, G., Stolz, L. A., Pei, D., Band, H., Shoelson, S. E., Walsh, C. T. (1994) The Phosphopeptide-Binding Specificity of Src Family SH2 Domains. Chemistry & Biology<\/em> 1, 99.<\/span><\/p>\n

12. Pei, D., Lorenz, U., Klingmuller, U., Neel, B. G., & Walsh, C. T. (1994) Intramolecular Regulation of Protein Tyrosine Phosphatase SH-PTP1: A New Function for Src Homology 2 Domains. Biochemistry<\/em> 33, 15483\u201315493.<\/span><\/p>\n

11. Lorenz, U., Ravichandran, K. S., Pei, D., Walsh, C. T., Burakoff, S. J., & Neel, B. G. (1994) Lck-dependent Tyrosyl Phosphorylation of the Protein Tyrosine Phosphatase SH-PTP1 in Murine Cells. Mol. Cell Biol.<\/em> 14, 1824.<\/span><\/p>\n

10. Pei, D. & Schultz, P. G. (1993) Artificial Nucleases, in The Nucleases, 2nd ed.; S. Linn, S. Lloyd, R. Roberts, Eds.; Cold Spring Harbor Laboratory Press, pp317-340.<\/span><\/p>\n

9. Pei, D., Neel, B. G., & Walsh, C. T. (1993) Overexpression, Purification, and Characterization of SHPTP1, a Src Homology 2-Containing Protein-Tyrosine-Phosphatase. Proc. Natl. Acad. Sci. USA<\/em> 90, 1092\u20131096.<\/span><\/p>\n

8. Williams, R. M., Glinka, T., Flanagan, M. E., Gallegos, R., Coffman, H., and Pei, D. (1992) Cannizzaro-Based O2-Dependent Cleavage of DNA by Quinocarcin. J. Am. Chem. Soc. <\/em>114, 733.<\/span><\/p>\n

7. Pei, D., Ulrich, H. D., & Schultz, P. G. (1991) A Combinatorial Approach Towards DNA Recognition. Science<\/em> 253, 1408.<\/span><\/p>\n

6. Pei, D. & Schultz, P. G. (1991) Engineering Protein Specificity: Gene Manipulation with Semisynthetic Nucleases. J. Am. Chem. Soc<\/em>. 113, 9398.<\/span><\/p>\n

5. Pei, D., Corey, D. R., & Schultz, P. G. (1990) Site-Specific Cleavage of Duplex DNA by a Semisynthetic Nuclease via Triple-Helix Formation. Proc. Natl. Acad. Sci. USA<\/em> 87, 9858.<\/span><\/p>\n

4. Pei, D. & Schultz, P. G. (1990) Site-Specific Cleavage of Duplex DNA with a l Repressor-Staphylococcal Nuclease Hybrid. J. Am. Chem. Soc.<\/em> 112, 4579.<\/span><\/p>\n

3. Corey, D. R., Pei, D., & Schultz, P. G. (1989) Sequence-Selective Hydrolysis of Duplex DNA by an Oligonucleotide-Directed Nuclease. J. Am. Chem. Soc.<\/em> 111, 8253.<\/span><\/p>\n

2. Corey, D. R., Pei, D., & Schultz, P. G. (1989) Generation of a Catalytic Sequence-Specific Hybrid DNase. Biochemistry<\/em> 28, 8277.<\/span><\/p>\n

1. Wu, D., Pei, D., & Qu, S. (1989) Activity Coefficients and Heat Capacity of Several Synthetic Porphyrin Derivatives. Chemical Journal of Chinese Universities<\/em> 10, 267.<\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Years 2011-2012 109. Kunys AR; Lian W; Pei D. Specificity profiling of protein-binding domains using one-bead-one-compound Peptide libraries. Curr. Protoc. Chem Biol. 2012 Dec 1;4(4):331-55. 108. Dewan V, Liu T, Chen KM, Qian Z, Xiao Y, Kleiman L, Mahasenan KV, Li C, Matsuo H, Pei D, Musier-Forsyth K. Cyclic Peptide Inhibitors of HIV-1 Capsid-Human Lysyl-tRNA<\/p>\n

Read More<\/a><\/p>\n","protected":false},"author":4,"featured_media":0,"parent":690,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"jetpack_post_was_ever_published":false,"footnotes":""},"class_list":["post-237","page","type-page","status-publish","hentry"],"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/P6vtp5-3P","_links":{"self":[{"href":"https:\/\/research.cbc.osu.edu\/pei.3\/wp-json\/wp\/v2\/pages\/237","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/research.cbc.osu.edu\/pei.3\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/research.cbc.osu.edu\/pei.3\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/research.cbc.osu.edu\/pei.3\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/research.cbc.osu.edu\/pei.3\/wp-json\/wp\/v2\/comments?post=237"}],"version-history":[{"count":19,"href":"https:\/\/research.cbc.osu.edu\/pei.3\/wp-json\/wp\/v2\/pages\/237\/revisions"}],"predecessor-version":[{"id":381,"href":"https:\/\/research.cbc.osu.edu\/pei.3\/wp-json\/wp\/v2\/pages\/237\/revisions\/381"}],"up":[{"embeddable":true,"href":"https:\/\/research.cbc.osu.edu\/pei.3\/wp-json\/wp\/v2\/pages\/690"}],"wp:attachment":[{"href":"https:\/\/research.cbc.osu.edu\/pei.3\/wp-json\/wp\/v2\/media?parent=237"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}