![\"\"](\"https:\/\/research.cbc.osu.edu\/schultz.133\/wp-content\/uploads\/2018\/05\/SERS-Metabolomics.png\")
<\/p>\n
References for further reading:<\/p>\n
- \n
- Lifu Xiao; Chuanqi Wang; Chen Dai; Laurie Littlepage; Jun Li; Zachary Schultz*, <\/strong>Untargeted Tumor Metabolomics with Liquid Chromatography\u2014Surface-Enhanced Raman Spectroscopy. Angewandte Chemie Int. Ed.\u00a0<\/em>2020,<\/strong> 59<\/em> (9), 3439-3443, DOI: 10.1002\/anie.201912387<\/li>\n
- Nguyen, A. and Schultz, Z.D.*<\/strong> \u201cQuantitative Online Sheath-flow Surface Enhanced Raman Spectroscopy Detection for Liquid Chromatography\u201d, Analyst, <\/em>2016<\/strong>, 141(12), 3630-3635, DOI: 10.1039\/C6AN00155F.<\/li>\n
- Riordan, C.M.<\/u>, Jacobs, K.T., Negri, P., and Schultz, Z.D.*<\/strong>, \u201cHigh Throughput Chemical Profiling in Urine by SERS\u201d, Faraday Discussions<\/em>, 2016<\/strong>, 187, <\/strong>473-484, DOI: 10.1039\/C5FD00155B.<\/li>\n
- Bailey, M.R., Pentecost, A.M., Selimovic, A., Martin, R.S., Schultz, Z. D.*<\/strong>, \u201cA Sheath-Flow Microfluidic Approach for combined SERS & Electrochemical Detection\u201d, Analytical Chemistry<\/em>, 2015<\/strong>, 87(8), 4347-4355, DOI: 10.1021\/acs.analchem.5b00075.<\/li>\n
- Negri, P., Flaherty, R.J., Dada, O.O., Schultz, Z.D.*<\/strong>, \u201cUltrasensitive Online SERS Detection of Structural Isomers Separated by Capillary Zone Electrophoresis\u201d, Chemical Communications<\/em>, 2014<\/strong>, 50(21), 2707-2710, DOI: 10.1039\/C3CC49030K.<\/li>\n
- Negri, P., Jacobs, K.T., Dada, O.O., Schultz, Z.D.*<\/strong>, \u201cUltrasensitive SERS Flow Detector Using Hydrodynamic Focusing\u201d Analytical Chemistry,<\/em> 2013<\/strong>, 85(21), 10159-10166 DOI: 10.1021\/ac401537k.<\/li>\n<\/ul>\n
PROTEIN RECEPTOR SIGNALING<\/strong>.\u00a0 Proteins on the surface and embedded with cellular membranes are key to communicating environmental signals to the machinery within cells, and are thus often drug targets.\u00a0 The ability to study the interaction of small molecules with receptors is a significant scientific challenge.\u00a0 By combining nanomaterials and state of the art spectroscopy and microscopy techniques, such as atomic force microscopy and tip-enhanced Raman scattering (TERS), we are able to monitor chemical signals associated with molecules interacting with specific proteins in intact cells.\u00a0 Understanding how molecules interact with signaling proteins offers promise to improve drug targeting as well as further investigate the role of membrane proteins in disease.<\/p>\n
![\"\"](\"https:\/\/research.cbc.osu.edu\/schultz.133\/wp-content\/uploads\/2018\/05\/TERS-Membranes.png\")
<\/p>\nReferences for further reading:<\/p>\n
- \n
- Sloan-Dennison, S.; Schultz, Z. D.<\/strong>, “Label-Free Plasmonic Nanostar Probes to Illuminate In Vitro Membrane Receptor Recognition.”\u00a0Chemical Science <\/i>2019, <\/b>10<\/em> (6), 1807-1815.\u00a0DOI: 10.1039\/C8SC05035J.<\/li>\n
- Sloan-Dennison, S.;\u00a0 <\/span>Bevins, M. R.;\u00a0 <\/span>Scarpitti, B. T.;\u00a0 <\/span>Sauv\u00e9, V. K.; Schultz, Z. D.<\/strong>*, Protein corona-resistant SERS tags for live cell detection of integrin receptors. Analyst <\/i>2019<\/b>, 44<\/i> (18), 5538-5546. DOI: 10.1039\/C9AN01056D.<\/li>\n
- Kim, J, Zeng, Z., Xiao, L., and Schultz, Z.D.*, \u201cElucidating Protein- Ligand Recognition with Combined Surface Plasmon Resonance and Surface Enhanced Raman Spectroscopy\u201d, Analytical <\/em>Chemistry, 2017, <\/strong>89(24), 13074-13081, DOI: 10.1021\/acs.analchem.7b04246.<\/li>\n
- Xiao, L., Bailey, K.A., Wang, H., and Schultz, Z.D.*, \u201cProbing Membrane Receptor – Ligand Specificity with Tip Enhanced Raman Scattering\u201d, Analytical Chemistry, <\/em>2017<\/strong>, 89(17), 9091-9099, DOI: 10.1021\/acs.analchem.7b01796.<\/li>\n
- Xiao, L., Wang, H., and Schultz, Z.D.* \u201cSelective Detection of RGD-Integrin Binding in Cancer Cells Using Tip Enhanced Raman Scattering Microscopy\u201d, Analytical Chemistry<\/em>, 2016<\/strong>, 88(12), 6547-6553, DOI: 10.1021\/acs.analchem.6b01344.<\/li>\n<\/ul>\n
ACTIVE PLASMONICS.<\/strong> Underlying all the problems we investigate is the basic science relevant to the signal enhancements incorporated into our measurements. \u00a0We are interested in understanding how nanomaterials interact with light, particularly with respect to how these properties alter the response from nearby molecules. This basic science serves as the basis for the development of future measurement techniques and other applications, such as photo-catalysts.<\/p>\n
![\"\"](\"https:\/\/research.cbc.osu.edu\/schultz.133\/wp-content\/uploads\/2018\/05\/Nanostructures1x3.png\")
<\/p>\nReferences for further reading:<\/p>\n
- \n
- Nelson, D.A. and Schultz, Z.D.<\/strong>*, “Impact of Plasmon Induced Optically Rectified Electric Fields On Second Harmonic Generation.”\u00a0Journal of Physical Chemistry C<\/em>\u00a02019, <\/strong><\/strong>123<\/i> (33), 20639-20648. DOI: 10.1021\/acs.jpcc.9b05685.<\/span><\/li>\n
- Nelson, D.A. and Schultz, Z.D.*<\/strong>, \u201cInfluence of Optically Rectified Electric Fields on the Plasmonic Photocatalysis of 4-Nitrothiophenol and 4-Aminothiophenol to 4,4-Dimercaptoazobenzene\u201d, Journal of Physical Chemistry C<\/em>, 2018<\/strong>, 122(15), 8581-8588, DOI: 10.1021\/acs.jpcc.8b00662.<\/li>\n
- Zeng, Z., Wang, H., Johns, P., Hartland, G.V., and Schultz, Z.D.*, \u201cPhotothermal Microscopy of Coupled Nanostructures and the Impact of Nanoscale Heating in Surface Enhanced Raman Spectroscopy\u201d, Journal of Physical Chemistry C<\/em>, 2017<\/strong>, 121(21), 11623-44631, DOI: 10.1021\/acs.jpcc.7b01220.<\/li>\n
- Wang, H., Yao, K., Parkhill, J.A.*, and Schultz, Z.D.* \u201cDetection of electron tunneling across plasmonic nanoparticle-film junctions using nitrile vibrations\u201d, Physical Chemistry Chemical Physics,<\/em> 2017<\/strong>, 19(8), 5786-5796, DOI: 10.1039\/C6CP08168A.<\/li>\n
- Kwasnieski, D.T.; Wang, H.; Schultz, Z.D.*, \u201cAlkyl-Nitrile Adlayers as Probes of Plasmonically Induced Electric Fields.\u201d Chemical Science, <\/em>2015<\/strong>.6(8), 4484 – 4494, DOI: 10.1039\/C5SC01265A.<\/li>\n
- Marr, J.M., Schultz, Z.D.*, \u201cImaging Electric Fields in SERS and TERS Using the Vibrational Stark Effect\u201d J. Physical Chemistry Letters, <\/em>2013,<\/strong> 4(19), 3268-3272, DOI: 10.1021\/jz401551u.<\/li>\n<\/ul>\n
SUPPORT.\u00a0\u00a0<\/strong>Our Research has been supported by the following entities:<\/p>\n
![\"\"](\"https:\/\/research.cbc.osu.edu\/schultz.133\/wp-content\/uploads\/2018\/05\/Funding2018.png\")
<\/p>\n","protected":false},"excerpt":{"rendered":"In the Schultz Lab, we believe the new scientific breakthroughs will be enabled by state of the art chemical measurement. Our research focuses on developing new tools for identifying molecules relevant to biomedical diagnostics and other applications.\u00a0 To do this, Read More …<\/a><\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-11","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/research.cbc.osu.edu\/schultz.133\/wp-json\/wp\/v2\/pages\/11","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/research.cbc.osu.edu\/schultz.133\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/research.cbc.osu.edu\/schultz.133\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/research.cbc.osu.edu\/schultz.133\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/research.cbc.osu.edu\/schultz.133\/wp-json\/wp\/v2\/comments?post=11"}],"version-history":[{"count":7,"href":"https:\/\/research.cbc.osu.edu\/schultz.133\/wp-json\/wp\/v2\/pages\/11\/revisions"}],"predecessor-version":[{"id":357,"href":"https:\/\/research.cbc.osu.edu\/schultz.133\/wp-json\/wp\/v2\/pages\/11\/revisions\/357"}],"wp:attachment":[{"href":"https:\/\/research.cbc.osu.edu\/schultz.133\/wp-json\/wp\/v2\/media?parent=11"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
- Nelson, D.A. and Schultz, Z.D.*<\/strong>, \u201cInfluence of Optically Rectified Electric Fields on the Plasmonic Photocatalysis of 4-Nitrothiophenol and 4-Aminothiophenol to 4,4-Dimercaptoazobenzene\u201d, Journal of Physical Chemistry C<\/em>, 2018<\/strong>, 122(15), 8581-8588, DOI: 10.1021\/acs.jpcc.8b00662.<\/li>\n
- Sloan-Dennison, S.;\u00a0 <\/span>Bevins, M. R.;\u00a0 <\/span>Scarpitti, B. T.;\u00a0 <\/span>Sauv\u00e9, V. K.; Schultz, Z. D.<\/strong>*, Protein corona-resistant SERS tags for live cell detection of integrin receptors. Analyst <\/i>2019<\/b>, 44<\/i> (18), 5538-5546. DOI: 10.1039\/C9AN01056D.<\/li>\n
- Nguyen, A. and Schultz, Z.D.*<\/strong> \u201cQuantitative Online Sheath-flow Surface Enhanced Raman Spectroscopy Detection for Liquid Chromatography\u201d, Analyst, <\/em>2016<\/strong>, 141(12), 3630-3635, DOI: 10.1039\/C6AN00155F.<\/li>\n