{"id":11,"date":"2018-05-03T15:29:28","date_gmt":"2018-05-03T19:29:28","guid":{"rendered":"https:\/\/research.cbc.osu.edu\/schultz.133\/?page_id=11"},"modified":"2026-08-10T14:20:47","modified_gmt":"2026-08-10T18:20:47","slug":"research","status":"publish","type":"page","link":"https:\/\/research.cbc.osu.edu\/schultz.133\/research\/","title":{"rendered":"Research"},"content":{"rendered":"<p>In the Schultz Lab, we believe the new scientific breakthroughs will be enabled by state of the art chemical measurement. Our research focuses on developing new tools for identifying molecules relevant to biomedical diagnostics and other applications.\u00a0 To do this, we build and develop instrumentation that takes advantage of chemical properties to characterize complex samples.\u00a0 The interaction between lasers and molecules provides unique information for detecting and identifying the components in complex systems.\u00a0 Understanding the basic science involved in chemical detection and manipulating these interactions has led to breakthrough technologies with tremendous potential.<\/p>\n<p><b>CHEMICAL DETECTION AND IMAGING.<\/b>. The ability to visualize and detect molecules can provide new insight into their function, serve as biomarkers for disease, and illustrate how local changes and alter reactions.\u00a0 Label-free methods of detection can further elucidate native and complex environments in a non-destructive manner.\u00a0 We are interested in using vibrational spectroscopies, such as Raman and Infrared, to detect, monitor, and image chemical behavior in complex systems.\u00a0 We are developing instrumentation and methodology that enables trace detection down to single molecule levels and super-resolution imaging on the nanometer length scale.\u00a0 These advances in instrumentation and methodology are poised to address research questions that challenge current techniques.<\/p>\n<p>&nbsp;<\/p>\n<p>References for further reading:<\/p>\n<ul>\n<li>Shoup DN, Scarpitti BT,\u00a0<strong>Schultz ZD<\/strong>*. A Wide-Field Imaging Approach for Simultaneous Super-Resolution Surface-Enhanced Raman Scattering Bioimaging and Spectroscopy.\u00a0<em>ACS Measurement Science Au.<\/em>\u00a0<strong>2022<\/strong>, 2 (4), 332-341. doi: 10.1021\/acsmeasuresciau.2c00013.<\/li>\n<li>Schorr, H.C.;\u00a0<strong>Schultz, Z.D.*<\/strong>\u00a0Digital surface enhanced Raman spectroscopy for quantifiable single molecule detection in flow.\u00a0<em>Analyst<\/em>\u00a0<strong>2024<\/strong>, 149, 3711-3715, DOI: 10.1039\/D4AN00801D.<\/li>\n<li>Scarpitti, B. T.; Fan, S.; Lomax-Vogt, M.; Lutton, A.; Olesik, J. W.;\u00a0<strong>Schultz, Z. D.*<\/strong>\u00a0Accurate Quantification and Imaging of Cellular Uptake Using Single-Particle Surface-Enhanced Raman Scattering.\u00a0<em>ACS Sensors<\/em>\u00a0<strong>2024<\/strong>, 9 (1), 73-80. DOI: 10.1021\/acssensors.3c01648.<\/li>\n<li>Rist, D.; DePalma, T.; Stagner, E.; Tallman, M. M.; Venere, M.; Skardal, A.;\u00a0<strong>Schultz, Z. D.*<\/strong>\u00a0Cancer Cell Targeting, Magnetic Sorting, and SERS Detection through Cell Surface Receptors.\u00a0<em>ACS Sensors<\/em>\u00a0<strong>2023<\/strong>, 8 (12), 4636-4645. DOI: 10.1021\/acssensors.3c01625<\/li>\n<li>Lifu Xiao; Chuanqi Wang; Chen Dai; Laurie Littlepage; Jun Li; <strong>Zachary Schultz*, <\/strong>Untargeted Tumor Metabolomics with Liquid Chromatography\u2014Surface-Enhanced Raman Spectroscopy. <em>Angewandte Chemie Int. Ed.\u00a0<\/em><strong>2020,<\/strong> <em>59<\/em> (9), 3439-3443, DOI: 10.1002\/anie.201912387<\/li>\n<\/ul>\n<p><strong>MACHINE LEARNING FOR SPECTROSCOPIC SENSORS<\/strong>.\u00a0 Vibrational spectroscopy yields intrinsic multivariate data that can be used to model complex biological and physical phenomena. The analysis of this data using machine learning (ML), and potentially generative AI algorithms offers new ways to leverage these measurements to solve complex research questions.\u00a0 We are currently using applying and exploring how ML can improve analysis in number of applications.\u00a0 In many of these examples, spontaneous Raman or infrared spectra are modeled to determine complex behavior.<\/p>\n<p>&nbsp;<\/p>\n<p>References for further reading:<\/p>\n<ul>\n<li>Poonia, M.; Witte, S.A.; Woodward, M.; Yadav, P.; Puri, S.; Santhanam R.; Jacob N.K.;\u00a0<strong>Schultz Z.D.*<\/strong>\u00a0Raman investigation of in vivo radiation exposure on melanin in murine hair.\u00a0<em>PNAS Nexus<\/em>.\u00a0<strong>2025<\/strong>;4(4). doi: 10.1093\/pnasnexus\/pgaf108.<\/li>\n<li>Rist, B. L.; Witte, S. A.;\u00a0<strong>Schultz, Z. D.*<\/strong>\u00a0Machine Learning Classification of Integrin-Expression-Based Magnetic Sorted SW 620 Cells by Simultaneous O-PTIR and SERS.\u00a0<em>Anal. Chem.<\/em>\u00a0<strong>2024<\/strong>, 96 (43), 17184-17191. DOI: 10.1021\/acs.analchem.4c02685.<\/li>\n<li>Witte, S.A.; Poonia, M.; Woodward, M.; Lu, L.; Yadav, M.; Jacob, N.K.;\u00a0<strong>Schultz, Z.D.*<\/strong>\u00a0Raman Spectroscopic Biodosimetry Using Protein in Murine Hair.\u00a0<em>Radiation Research<\/em>.\u00a0<strong>2025<\/strong>. IN PRESS doi:\u00a0<a href=\"https:\/\/doi.org\/10.1667\/RADE-25-00046.1\">10.1667\/rade-25-00046.1<\/a>.<\/li>\n<\/ul>\n<p><strong>ACTIVE PLASMONICS.<\/strong> Underlying all the problems we investigate is the basic science relevant to the signal enhancements incorporated into our measurements. \u00a0We are interested in understanding how nanomaterials interact with light, particularly with respect to how these properties alter the response from nearby molecules. This basic science serves as the basis for the development of future measurement techniques and other applications, such as photo-catalysts.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-29 aligncenter\" src=\"https:\/\/research.cbc.osu.edu\/schultz.133\/wp-content\/uploads\/2018\/05\/Nanostructures1x3.png\" alt=\"\" width=\"860\" height=\"263\" srcset=\"https:\/\/research.cbc.osu.edu\/schultz.133\/wp-content\/uploads\/2018\/05\/Nanostructures1x3.png 1210w, https:\/\/research.cbc.osu.edu\/schultz.133\/wp-content\/uploads\/2018\/05\/Nanostructures1x3-300x92.png 300w, https:\/\/research.cbc.osu.edu\/schultz.133\/wp-content\/uploads\/2018\/05\/Nanostructures1x3-768x235.png 768w, https:\/\/research.cbc.osu.edu\/schultz.133\/wp-content\/uploads\/2018\/05\/Nanostructures1x3-1024x313.png 1024w\" sizes=\"auto, (max-width: 860px) 100vw, 860px\" \/><\/p>\n<p>References for further reading:<\/p>\n<ul>\n<li>Fan, S.*<sup>\u2020<\/sup>; Cheng, R.<sup>\u2020<\/sup>; Lin, H.<sup>\u2020<\/sup>; Luo, Z.; \u00a0Smith, A.E.; Wang, C.; He, J.; Scarpitti, B.T.; Shoup, D.N.; Schorr, H.C.; Liang, E.; Ye,J.; Cheng, J.X.*; <strong>Schultz, Z.D.* <\/strong>Single-particle surface-enhanced coherent anti\u2013Stokes Raman scattering: Nanoparticle design and mechanism. <em>Science Advances<\/em> <strong>2026<\/strong>. 12(5) eady0545, doi: 10.1126\/sciadv.ady0545<\/li>\n<li>Fan, S.; Scarpitti, B.T.; Smith, A.E.; Luo, Z.; Ye, J.; Schultz, Z.D. Linker-Free Synthesis of Core\/Satellite Nanoparticles for Single-Particle Surface-Enhanced Raman Spectroscopy and Photocatalysis.\u00a0<em>Nano Lett.<\/em>\u00a0<strong>2025.<\/strong>\u00a0IN PRESS doi: 10.1021\/acs.nanolett.5c00763.<\/li>\n<li>Landaeata, E.; Kadosh, N.;\u00a0<strong>Schultz, Z.D.<\/strong>, Mechanistic Study of plasmon assisted in situ photoelectrochemical CO<sub>2<\/sub>\u00a0reduction to acetate with a Ag\/Cu<sub>2<\/sub>O nanodendrite electrode.\u00a0<em>ACS Catalysis<\/em>\u00a0<strong>2023<\/strong>, 13, 1638-1648. doi: 10.1021\/acscatal.2c05082<\/li>\n<li>Nelson, D.A. and <strong>Schultz, Z.D.*<\/strong>, \u201cInfluence of Optically Rectified Electric Fields on the Plasmonic Photocatalysis of 4-Nitrothiophenol and 4-Aminothiophenol to 4,4-Dimercaptoazobenzene\u201d, <em>Journal of Physical Chemistry C<\/em>, <strong>2018<\/strong>, 122(15), 8581-8588, DOI: 10.1021\/acs.jpcc.8b00662.<\/li>\n<li>Zeng, Z., Wang, H., Johns, P., Hartland, G.V., and Schultz, Z.D.*, \u201cPhotothermal Microscopy of Coupled Nanostructures and the Impact of Nanoscale Heating in Surface Enhanced Raman Spectroscopy\u201d, <em>Journal of Physical Chemistry C<\/em>, <strong>2017<\/strong>, 121(21), 11623-44631, DOI: 10.1021\/acs.jpcc.7b01220.<\/li>\n<li>Wang, H., Yao, K., Parkhill, J.A.*, and Schultz, Z.D.* \u201cDetection of electron tunneling across plasmonic nanoparticle-film junctions using nitrile vibrations\u201d, <em>Physical Chemistry Chemical Physics,<\/em> <strong>2017<\/strong>, 19(8), 5786-5796, DOI: 10.1039\/C6CP08168A.<\/li>\n<li>Kwasnieski, D.T.; Wang, H.; Schultz, Z.D.*, \u201cAlkyl-Nitrile Adlayers as Probes of Plasmonically Induced Electric Fields.\u201d <em>Chemical Science, <\/em><strong>2015<\/strong>.6(8), 4484 &#8211; 4494, DOI: 10.1039\/C5SC01265A.<\/li>\n<li>Marr, J.M., Schultz, Z.D.*, \u201cImaging Electric Fields in SERS and TERS Using the Vibrational Stark Effect\u201d <em>J. Physical Chemistry Letters, <\/em><strong>2013,<\/strong> 4(19), 3268-3272, DOI: 10.1021\/jz401551u.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In the Schultz Lab, we believe the new scientific breakthroughs will be enabled by state of the art chemical measurement. Our research focuses on developing new tools for identifying molecules relevant to biomedical diagnostics and other applications.\u00a0 To do this, <a class=\"more-link\" href=\"https:\/\/research.cbc.osu.edu\/schultz.133\/research\/\">Read More &#8230;<\/a><\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-11","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/research.cbc.osu.edu\/schultz.133\/wp-json\/wp\/v2\/pages\/11","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/research.cbc.osu.edu\/schultz.133\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/research.cbc.osu.edu\/schultz.133\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/research.cbc.osu.edu\/schultz.133\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/research.cbc.osu.edu\/schultz.133\/wp-json\/wp\/v2\/comments?post=11"}],"version-history":[{"count":8,"href":"https:\/\/research.cbc.osu.edu\/schultz.133\/wp-json\/wp\/v2\/pages\/11\/revisions"}],"predecessor-version":[{"id":722,"href":"https:\/\/research.cbc.osu.edu\/schultz.133\/wp-json\/wp\/v2\/pages\/11\/revisions\/722"}],"wp:attachment":[{"href":"https:\/\/research.cbc.osu.edu\/schultz.133\/wp-json\/wp\/v2\/media?parent=11"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}