{"id":409,"date":"2017-08-17T12:34:24","date_gmt":"2017-08-17T16:34:24","guid":{"rendered":"https:\/\/research.cbc.osu.edu\/sevov.1\/?page_id=409"},"modified":"2025-05-12T06:20:08","modified_gmt":"2025-05-12T10:20:08","slug":"research","status":"publish","type":"page","link":"https:\/\/research.cbc.osu.edu\/sevov.1\/","title":{"rendered":""},"content":{"rendered":"<p><span style=\"text-decoration: underline;\"><strong>Welcome to the Sevov Lab!<\/strong><\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-989 alignleft\" src=\"https:\/\/research.cbc.osu.edu\/sevov.1\/wp-content\/uploads\/2023\/11\/Screenshot-2023-11-26-at-3.11.26\u202fPM.png\" alt=\"\" width=\"142\" height=\"136\" srcset=\"https:\/\/research.cbc.osu.edu\/sevov.1\/wp-content\/uploads\/2023\/11\/Screenshot-2023-11-26-at-3.11.26\u202fPM.png 1272w, https:\/\/research.cbc.osu.edu\/sevov.1\/wp-content\/uploads\/2023\/11\/Screenshot-2023-11-26-at-3.11.26\u202fPM-300x288.png 300w, https:\/\/research.cbc.osu.edu\/sevov.1\/wp-content\/uploads\/2023\/11\/Screenshot-2023-11-26-at-3.11.26\u202fPM-1024x984.png 1024w, https:\/\/research.cbc.osu.edu\/sevov.1\/wp-content\/uploads\/2023\/11\/Screenshot-2023-11-26-at-3.11.26\u202fPM-768x738.png 768w\" sizes=\"auto, (max-width: 142px) 100vw, 142px\" \/><\/p>\n<p>The Sevov lab develops strategies at the interface of homogeneous catalysis and electrochemistry for the sustainable utilization of electricity that is generated from renewable sources. By treating electrical energy as a reagent, our group aims to demonstrate that toxic, explosive, or expensive reagents, which drive traditional synthetic organic processes, can be replaced with inexpensive and benign additives. This will enable organic synthesis to be performed in a safe, sustainable, and scalable manner. In addition to the application of electrical energy to synthesis, we seek to design large scale energy storage systems that can assist with the integration of intermittent electrical loads from renewable sources into the electrical grid. Sevov lab members addressing these challenges will be trained and exposed to the multidisciplinary fields of organic and organometallic synthesis, catalyst design, mechanistic study, materials development, and electroanalytical evaluation.<\/p>\n<p>Read some of our <span style=\"color: #c81b01;\"><a style=\"color: #c81b01;\" href=\"https:\/\/research.cbc.osu.edu\/sevov.1\/publications\/\"><strong>Publications<\/strong><\/a><\/span> hear about some some of our projects in our own words:<\/p>\n<p><iframe loading=\"lazy\" title=\"Early Career Finalist - Christo Sevov\" width=\"790\" height=\"444\" src=\"https:\/\/www.youtube.com\/embed\/R7JfTlcyq-o?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p><span style=\"text-decoration: underline;\"><strong>Electrically-Driven Homogeneous Catalysis<\/strong><\/span><\/p>\n<p>The development of metal-catalyzed reactions has revolutionized synthetic organic chemistry. Because many of these catalytic processes necessitate changes to the oxidation state of the metal, catalysts are generally of noble metals with vetted ligands that facilitate the redox events. To render these transformations favorable, high energy additives are added or substrates are prefunctionalized. Our lab is interested in utilizing electrochemistry in combination with homogeneous catalysis to drive chemical reactions by modulating the input of electrical energy, which allows electrons to be treated like inexpensive reagents. In doing so, our lab will develop methods for complex organic synthesis that (i) utilize earth-abundant metal catalysts, (ii) convert stoichiometric reagents into catalysts, and (iii) access high-energy intermediates under mild conditions to accelerate turnover-limiting processes.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-993\" src=\"https:\/\/research.cbc.osu.edu\/sevov.1\/wp-content\/uploads\/2023\/11\/Screenshot-2023-11-26-at-3.41.13\u202fPM.png\" alt=\"\" width=\"3596\" height=\"1516\" srcset=\"https:\/\/research.cbc.osu.edu\/sevov.1\/wp-content\/uploads\/2023\/11\/Screenshot-2023-11-26-at-3.41.13\u202fPM.png 3596w, https:\/\/research.cbc.osu.edu\/sevov.1\/wp-content\/uploads\/2023\/11\/Screenshot-2023-11-26-at-3.41.13\u202fPM-300x126.png 300w, https:\/\/research.cbc.osu.edu\/sevov.1\/wp-content\/uploads\/2023\/11\/Screenshot-2023-11-26-at-3.41.13\u202fPM-1024x432.png 1024w, https:\/\/research.cbc.osu.edu\/sevov.1\/wp-content\/uploads\/2023\/11\/Screenshot-2023-11-26-at-3.41.13\u202fPM-768x324.png 768w, https:\/\/research.cbc.osu.edu\/sevov.1\/wp-content\/uploads\/2023\/11\/Screenshot-2023-11-26-at-3.41.13\u202fPM-1536x648.png 1536w, https:\/\/research.cbc.osu.edu\/sevov.1\/wp-content\/uploads\/2023\/11\/Screenshot-2023-11-26-at-3.41.13\u202fPM-2048x863.png 2048w\" sizes=\"auto, (max-width: 3596px) 100vw, 3596px\" \/><\/p>\n<p><strong><span style=\"text-decoration: underline;\">Late-Stage Drug Diversification<\/span><\/strong><\/p>\n<p>Coupling reactions between aryl electrophiles and alkyl\/perfluoroalkyl precursors have inspired elegant methodologies that leverage electrochemical, photochemical, or thermal activation modalities. Our group develops persistent organonickel complexes that serve as stoichiometric platforms for cross-coupling. Aryl, heteroaryl, or vinyl complexes of Ni can be inexpensively prepared on multigram scale by mild electroreduction from the corresponding electrophile. Organonickel complexes can be isolated and stored or telescoped directly to reliably diversify drug-like molecules. <span style=\"font-size: revert; color: initial; font-family: -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, Oxygen-Sans, Ubuntu, Cantarell, 'Helvetica Neue', sans-serif;\">We envision these Ni complexes as modern organometallic reagents for the reinvigorated field of radical chemistry.\u00a0<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-995\" src=\"https:\/\/research.cbc.osu.edu\/sevov.1\/wp-content\/uploads\/2023\/11\/Screenshot-2023-11-26-at-4.12.11\u202fPM.png\" alt=\"\" width=\"3026\" height=\"814\" srcset=\"https:\/\/research.cbc.osu.edu\/sevov.1\/wp-content\/uploads\/2023\/11\/Screenshot-2023-11-26-at-4.12.11\u202fPM.png 3026w, https:\/\/research.cbc.osu.edu\/sevov.1\/wp-content\/uploads\/2023\/11\/Screenshot-2023-11-26-at-4.12.11\u202fPM-300x81.png 300w, https:\/\/research.cbc.osu.edu\/sevov.1\/wp-content\/uploads\/2023\/11\/Screenshot-2023-11-26-at-4.12.11\u202fPM-1024x275.png 1024w, https:\/\/research.cbc.osu.edu\/sevov.1\/wp-content\/uploads\/2023\/11\/Screenshot-2023-11-26-at-4.12.11\u202fPM-768x207.png 768w, https:\/\/research.cbc.osu.edu\/sevov.1\/wp-content\/uploads\/2023\/11\/Screenshot-2023-11-26-at-4.12.11\u202fPM-1536x413.png 1536w, https:\/\/research.cbc.osu.edu\/sevov.1\/wp-content\/uploads\/2023\/11\/Screenshot-2023-11-26-at-4.12.11\u202fPM-2048x551.png 2048w\" sizes=\"auto, (max-width: 3026px) 100vw, 3026px\" \/><\/p>\n<p><strong><span style=\"text-decoration: underline;\">Large-Scale Energy Storage<\/span><\/strong><\/p>\n<p>Integration of electrical energy that is harnessed by wind turbines or photovoltaics into the electrical grid requires large-scale energy storage systems that can modulate the variable and intermittent nature of these energy sources. However, the immense scale of this challenge precludes the use of most established battery technologies due to their cost. Our group will pursue an interdisciplinary approach of organic synthesis, polymers and materials development, and electroanalytical chemistry to invent scalable energy storage devices that utilize inexpensive liquid anode and cathode materials for shuttling and storing energy.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter  wp-image-996\" src=\"https:\/\/research.cbc.osu.edu\/sevov.1\/wp-content\/uploads\/2023\/11\/Screenshot-2023-11-26-at-4.14.54\u202fPM.png\" alt=\"\" width=\"588\" height=\"304\" srcset=\"https:\/\/research.cbc.osu.edu\/sevov.1\/wp-content\/uploads\/2023\/11\/Screenshot-2023-11-26-at-4.14.54\u202fPM.png 1780w, https:\/\/research.cbc.osu.edu\/sevov.1\/wp-content\/uploads\/2023\/11\/Screenshot-2023-11-26-at-4.14.54\u202fPM-300x155.png 300w, https:\/\/research.cbc.osu.edu\/sevov.1\/wp-content\/uploads\/2023\/11\/Screenshot-2023-11-26-at-4.14.54\u202fPM-1024x529.png 1024w, https:\/\/research.cbc.osu.edu\/sevov.1\/wp-content\/uploads\/2023\/11\/Screenshot-2023-11-26-at-4.14.54\u202fPM-768x397.png 768w, https:\/\/research.cbc.osu.edu\/sevov.1\/wp-content\/uploads\/2023\/11\/Screenshot-2023-11-26-at-4.14.54\u202fPM-1536x794.png 1536w\" sizes=\"auto, (max-width: 588px) 100vw, 588px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Welcome to the Sevov Lab! The Sevov lab develops strategies at the interface of homogeneous catalysis and electrochemistry for the sustainable utilization of electricity that is generated from renewable sources. By treating electrical energy as a reagent, our group aims to demonstrate that toxic, explosive, or expensive reagents, which drive traditional synthetic organic processes, can be replaced with inexpensive and benign additives. This will enable organic synthesis to be performed in a safe, sustainable, and&hellip; <\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-409","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/research.cbc.osu.edu\/sevov.1\/wp-json\/wp\/v2\/pages\/409","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/research.cbc.osu.edu\/sevov.1\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/research.cbc.osu.edu\/sevov.1\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/research.cbc.osu.edu\/sevov.1\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/research.cbc.osu.edu\/sevov.1\/wp-json\/wp\/v2\/comments?post=409"}],"version-history":[{"count":24,"href":"https:\/\/research.cbc.osu.edu\/sevov.1\/wp-json\/wp\/v2\/pages\/409\/revisions"}],"predecessor-version":[{"id":1103,"href":"https:\/\/research.cbc.osu.edu\/sevov.1\/wp-json\/wp\/v2\/pages\/409\/revisions\/1103"}],"wp:attachment":[{"href":"https:\/\/research.cbc.osu.edu\/sevov.1\/wp-json\/wp\/v2\/media?parent=409"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}