The related projects are designed to increase the current understanding of the fragmentation patterns of activated protonated peptides with particular interest on the formation and fragmentation of isobaric “b” ion structures. The long range goals of this work are to provide additional “rules” that will increase the confidence in automated primary sequencing of peptides and proteins by tandem mass spectrometry and, ultimately, to relate information on gas-phase fragmentation patterns and energetics of dissociation to the gas-phase conformations of intact and fragment peptides and proteins.
Ongoing Projects in the group
- b2, b3 ion structure (under construction)
- SQID peptide identification algorithm (under construction)
- Conformational determination of peptides in the gas phase by hydrogen deuterium exchange
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