Publications

  1. Yu, R.R., Mahto, S.K., Justus, K., Alexander, M.M., Howard, CJ, and Ottesen, J.J. “Hybrid phase ligation for efficient synthesis of histone proteins” (2016), Org. Biomol. Chem. epub Jan 29, doi: 10.1039/C5OB02195B
    (Selected by the journal as a 2016 Hot Article in Organic & Biomolecular Chemistry)
  2. Wike, C.L., Graves, H.K., Hawkins, R., Gibson, M.D., Ferdinand, M.B., Zhang, T., Chen, Z., Hudson, D.F., Ottesen, J.J., Poirier, M.G., Schumacher, J., Tyler, J.K. “Aurora-A mediated histone H3 phosphorylation of threonine 118 controls condensin I and cohesin occupancy in mitosis” (2016) eLife, epub Feb 16, doi: 10.7554/eLife.11402.
  3. Howard, C.J., Yu, R.R., Gardner, M.L., Shimko, J.C., Ottesen, J.J. “Chemical and Biological Tools for the Preparation of Modified Histone Proteins” (2015).Curr. Chem. 363, 193-226. doi: 10.1007/128_2015_629.
  4. Bernier, M. ,Luo, Y., Nwokelo, K.C., Goodwin, M., Dreher, S.J., Zhang, P., Parthun, M.R., Fondufe-Mittendorf, Y.N., Ottesen, J.J., Poirier, M.G., “Linker histone H1 and H3K56 Acetylation Are Antagonistic Regulators of Nucleosome Dynamics”, (2015)  Nat. Comm., doi: 10.1038/NCOMMS10152.
  5. Brehove, M., Wang, T., North, J., Luo, Y., Dreher, S.J., Shimko, J.C., Ottesen, J.J., Luger, K., Poirier, M.G., “Histone Core Phosphorylation Regulates DNA Accessibility”, (2015). Biol. Chem. 290(37), 22612-22621. doi: 10.1074/jbc.M115.661363.
  6. Chatterjee, N., North, J.A., Dechassa, M.L., Manohar, M., Prasad, R., Luger, K., Ottesen, J.J., Poirier, M.G., Bartholomew, B.B. “Histone acetylation near the nucleosome dyad axis enhances nucleosome disassembly by RSC and SWI/SNF (2015). Mol. Cell. Biol., 35 (23): 4083-92 doi: 10.1128/MCB.0041-15.
  7. North, J.A., Simon, M., Ferdinand, M.B., Shoffner, M.A., Picking, J.W., Howard, C.J., Mooney, A.M., van Noort, J., *Poirier, M.G., and *Ottesen, J.J. “Histone H3 Phosphorylation Near the Nucleosome Dyad Alters Chromatin Structure” (2014). Nucleic Acids Research, 42(8), 4922-4933. doi: 10.1093/nar/gku150.
  8. Shimko, J.C., Howard, C.J., Poirier, M.G., and *Ottesen, J.J. “Preparing Semisynthetic and Fully Synthetic Histones H3 and H4 to Modify the Nucleosome Core” in volume “Protein Acetylation: Methods and Protocols” (2013) of Methods in Molecular Biology, 981, 177-192. DOI: 10.1007/978-1-62703-305-3_14.
  9. North, J.A., Shimko, J.C., Javaid, S., Mooney, A.M., Shoffner, M.A., Rose, S.D., Bundschuh, R., Fishel, R., Ottesen, JJ. and *Poirier, J.G.; “Regulation of the Nucleosome Unwrapping Rate Controls DNA Accessibility”, (2012). Nucleic Acids Research, 40(20), 10215-10227. doi:10.1093/nar/gks747.
  10. Mahto, S.K., Howard, C.J., Shimko, J.C., and *Ottesen, J.J.; “A Reversible Protection Strategy to Improve Fmoc-SPPS of Peptide Thioesters by the N-Acylurea Approach”, (2011).  ChemBioChem, 12(16), 2488-2494; doi: 10.1002/cbic.201100472.
  11. Simon, M., North, J.A., Shimko, J.C., Forties, R.A., Ferdinand, M.B., Manohar, M., Zheng, M., Fishel, R., *Ottesen, J.J., *Poirier, M.G.; “Histone Fold Modifications Control Nucleosome Unwrapping and Disassembly”, (2011). Proc. Nat. Acad. Sci. USA, 108(31), 12711-12716; doi: 10.1073/pnas.1106264108.
  12. Shimko, J.C., North, J., *Poirier, M.G., *Ottesen, J.J., “Preparation of Fully Synthetic Histone H3 Reveals that Acetyl-Lysine 56 Facilitates Protein Binding Within Nucleosomes”, (2011). J. Mol. Biol., 408(2), 187-204; doi: 10.1016/j.jmb.2011.01.003.
  13. North, J.A., Javaid, S., Ferdinand, M.B., Chatterjee, N., Picking, J.W., Shoffner, M., Nakkula, R.J, Bartholomew, B., *Ottesen, J.J., *Fishel, R., and *Poirier, M.G., “Phosphorylation of Histone H3(T118) Alters Nucleosome Dynamics and Remodeling”, (2011). Nucleic Acids Research, 38(15), 6465-6474; doi: 10.1093/nar/gkr304.
  14. Javaid, S., Manohar, M., Punja, H., Mooney, A., *Ottesen, J.J., *Poirier, M.G., *Fishel, R.A. “Nucleosome remodeling catalyzed by the human hMSH2-hMSH6 Mismatch Recognition Complex”, (2009). Mol. Cell., 36, 1086-1094; doi: 10.1016/j.molcel.2009.12.010.
  15. Li, X., Fekner, T., Ottesen, J.J., Chan, M.K. “A Pyrrolysine Analog for Site-Specific Protein Ubiquitination”, (2009). Angew. Chem., 48(48), 9184-9187; doi: 10.1002/anie.200904472.
  16. Manohar, M., Mooney, A.M., Picking, J.W., Edon, A. Nakkula, R.J., Fishel, R.A.,*Poirier, M.G., and *Ottesen, J.J. (2009). Acetylation of Histone H3 at the Nucleosome Dyad Reduces DNA-Histone Binding, J. Biol. Chem., 284, 23312-23321; doi:10.1074/jbc.M109.003202.
  17. Ottesen, J.J., Bar-Dagan, M., Giovani, B., Muir, T.W. (2008) An Amalgamation of Solid Phase Peptide Synthesis and Ribosomal Peptide Synthesis. Biopolymers (Peptide Science), 90, 406-414.
  18. Ottesen, J.J., Huse, M., Sekedat, M.D., Muir, T.W. (2004) Semisynthesis of Phosphovariants of Smad2 Reveals a Substrate Preference of the Activated TbRI Kinase.
  19. Wilson K.A., Kalkum M., Ottesen J., Yuzenkova J., Chait B.T., Landick R., Muir T., Severinov K., Darst S.A. (2004). Structure of Microcin J25, a Peptide Inhibitor of Bacterial RNA Polymerase, is a Lassoed Tail. J. Am. Chem. Soc., 125, 12475-12483.
  20. Cowburn, D., Shekhtman, A., Xu, R., Ottesen, J.J., Muir, T.W. (2004) “Segmental Isotopic Labeling for Structural Biological Applications of NMR,” in Methods in Molecular Biology, vol 278 (Downing, A.K., ed.) Humana Press Inc, Totowa NJ, pp. 47-56.
  21. Ottesen, J.J., Blaschke, U.K., Cowburn, D., Muir, T.W. (2003) Segmental isotopic labeling; prospects for a new tool to study the structure-function relationships in multi-domain proteins. Biol. Mag. Res., 20, 35-51.
  22. Ottesen, J.J., Imperiali, B. (2001) Design of a Discretely Folded Mini-Protein Motif with Predominantly b-Structure. Nat. Struct. Biol., 8, 535-539.
  23. Mezo, A.R., Ottesen, J.J., Imperiali, B. (2001) Discovery and Characterization of a Discretely Folded Homotrimeric BBA Peptide. J. Am. Chem. Soc., 123, 1002-1003.
  24. Imperiali, B., Ottesen, J.J. (1999) Uniquely Folded Mini-Protein Motifs. J. Pept. Res., 54, 177-184.
  25. Imperiali, B., Ottesen, J.J. (1998) Design Strategies for the Construction of Independently Folded Polypeptide Motifs. Biopolymers, 47, 23-29.
  26. Struthers, M.D., Ottesen, J.J., Imperiali, B. (1998) Design and NMR Analyses of Compact, Independently Folded BBA Motifs. Folding & Design, 3, 95-104.