Publications

Musier-Forsyth Publications

  1. Jin, D, Wek, SA, Kudlapur, NT, Cantara, WA, Bakhtina, M, Wek, RC et al.. Disease-associated mutations in a bifunctional aminoacyl-tRNA synthetase gene elicit the integrated stress response. J Biol Chem. 2021; :101203. doi: 10.1016/j.jbc.2021.101203. PubMed PMID:34537243 .
  2. Dayeh, DM, Cantara, WA, Kitzrow, JP, Musier-Forsyth, K, Nakanishi, K. Correction to 'Argonaute-based programmable RNase as a tool for cleavage of highly-structured RNA'. Nucleic Acids Res. 2021;49 (16):9606. doi: 10.1093/nar/gkab742. PubMed PMID:34403465 PubMed Central PMC8450089.
  3. Hu, QH, Williams, MT, Shulgina, I, Fossum, CJ, Weeks, KM, Adams, LM et al.. Editing Domain Motions Preorganize the Synthetic Active Site of Prolyl-tRNA Synthetase. ACS Catal. 2020;10 (17):10229-10242. doi: 10.1021/acscatal.0c02381. PubMed PMID:34295570 PubMed Central PMC8293909.
  4. Harpster, C, Boyle, E, Musier-Forsyth, K, Kankia, B. HIV-1 genomic RNA U3 region forms a stable quadruplex-hairpin structure. Biophys Chem. 2021;272 :106567. doi: 10.1016/j.bpc.2021.106567. PubMed PMID:33713997 PubMed Central PMC8051326.
  5. Kankia, B. Quadruplex-Templated and Catalyzed Ligation of Nucleic Acids. Chembiochem. 2021;22 (7):1261-1267. doi: 10.1002/cbic.202000754. PubMed PMID:33217115 .
  6. Vargas-Rodriguez, O, Bakhtina, M, McGowan, D, Abid, J, Goto, Y, Suga, H et al.. Human trans-editing enzyme displays tRNA acceptor-stem specificity and relaxed amino acid selectivity. J Biol Chem. 2020;295 (48):16180-16190. doi: 10.1074/jbc.RA120.015981. PubMed PMID:33051185 PubMed Central PMC7705315.
  7. Sarni, S, Biswas, B, Liu, S, Olson, ED, Kitzrow, JP, Rein, A et al.. HIV-1 Gag protein with or without p6 specifically dimerizes on the viral RNA packaging signal. J Biol Chem. 2020;295 (42):14391-14401. doi: 10.1074/jbc.RA120.014835. PubMed PMID:32817318 PubMed Central PMC7573273.
  8. Liu, S, Refaei, M, Liu, S, Decker, A, Hinerman, JM, Herr, AB et al.. Hairpin RNA-induced conformational change of a eukaryotic-specific lysyl-tRNA synthetase extension and role of adjacent anticodon-binding domain. J Biol Chem. 2020;295 (34):12071-12085. doi: 10.1074/jbc.RA120.013852. PubMed PMID:32611767 PubMed Central PMC7443506.
  9. Liu, S, Kaddis Maldonado, R, Rye-McCurdy, T, Binkley, C, Bah, A, Chen, EC et al.. Rous Sarcoma Virus Genomic RNA Dimerization Capability In Vitro Is Not a Prerequisite for Viral Infectivity. Viruses. 2020;12 (5):. doi: 10.3390/v12050568. PubMed PMID:32455905 PubMed Central PMC7291142.
  10. Tuske, S, Zheng, J, Olson, ED, Ruiz, FX, Pascal, BD, Hoang, A et al.. Integrative structural biology studies of HIV-1 reverse transcriptase binding to a high-affinity DNA aptamer. Curr Res Struct Biol. 2020;2 :116-129. doi: 10.1016/j.crstbi.2020.06.002. PubMed PMID:33870216 PubMed Central PMC8052095.
  11. Kuzmishin Nagy, AB, Bakhtina, M, Musier-Forsyth, K. Trans-editing by aminoacyl-tRNA synthetase-like editing domains. Enzymes. 2020;48 :69-115. doi: 10.1016/bs.enz.2020.07.002. PubMed PMID:33837712 .
  12. Brigham, BS, Kitzrow, JP, Reyes, JC, Musier-Forsyth, K, Munro, JB. Intrinsic conformational dynamics of the HIV-1 genomic RNA 5'UTR. Proc Natl Acad Sci U S A. 2019;116 (21):10372-10381. doi: 10.1073/pnas.1902271116. PubMed PMID:31068467 PubMed Central PMC6534999.
  13. Musier-Forsyth, K. Aminoacyl-tRNA synthetases and tRNAs in human disease: an introduction to the JBC Reviews thematic series. J Biol Chem. 2019;294 (14):5292-5293. doi: 10.1074/jbc.REV119.007721. PubMed PMID:30799306 PubMed Central PMC6462500.
  14. Qualley, DF, Cooper, SE, Ross, JL, Olson, ED, Cantara, WA, Musier-Forsyth, K et al.. Solution Conformation of Bovine Leukemia Virus Gag Suggests an Elongated Structure. J Mol Biol. 2019;431 (6):1203-1216. doi: 10.1016/j.jmb.2019.01.036. PubMed PMID:30731090 PubMed Central PMC6424597.
  15. Jin, D, Musier-Forsyth, K. Role of host tRNAs and aminoacyl-tRNA synthetases in retroviral replication. J Biol Chem. 2019;294 (14):5352-5364. doi: 10.1074/jbc.REV118.002957. PubMed PMID:30700559 PubMed Central PMC6462514.
  16. Zhang, C, Cantara, W, Jeon, Y, Musier-Forsyth, K, Grigorieff, N, Lyumkis, D et al.. Analysis of discrete local variability and structural covariance in macromolecular assemblies using Cryo-EM and focused classification. Ultramicroscopy. 2019;203 :170-180. doi: 10.1016/j.ultramic.2018.11.016. PubMed PMID:30528101 PubMed Central PMC6476647.
  17. Lomidze, L, Williford, TH, Musier-Forsyth, K, Kankia, B. Isothermal amplification of long DNA segments by quadruplex priming amplification. Anal Methods. 2018;10 (25):2972-2979. doi: 10.1039/C8AY00843D. PubMed PMID:30505353 PubMed Central PMC6261523.
  18. Chen, L, Tanimoto, A, So, BR, Bakhtina, M, Magliery, TJ, Wysocki, VH et al.. Stoichiometry of triple-sieve tRNA editing complex ensures fidelity of aminoacyl-tRNA formation. Nucleic Acids Res. 2019;47 (2):929-940. doi: 10.1093/nar/gky1153. PubMed PMID:30418624 PubMed Central PMC6344894.
  19. Wu, W, Hatterschide, J, Syu, YC, Cantara, WA, Blower, RJ, Hanson, HM et al.. Human T-cell leukemia virus type 1 Gag domains have distinct RNA-binding specificities with implications for RNA packaging and dimerization. J Biol Chem. 2018;293 (42):16261-16276. doi: 10.1074/jbc.RA118.005531. PubMed PMID:30217825 PubMed Central PMC6200928.
  20. Dayeh, DM, Cantara, WA, Kitzrow, JP, Musier-Forsyth, K, Nakanishi, K. Argonaute-based programmable RNase as a tool for cleavage of highly-structured RNA. Nucleic Acids Res. 2018;46 (16):e98. doi: 10.1093/nar/gky496. PubMed PMID:29897478 PubMed Central PMC6144825.
  21. Antonucci, JM, Kim, SH, St Gelais, C, Bonifati, S, Li, TW, Buzovetsky, O et al.. SAMHD1 Impairs HIV-1 Gene Expression and Negatively Modulates Reactivation of Viral Latency in CD4+ T Cells. J Virol. 2018;92 (15):. doi: 10.1128/JVI.00292-18. PubMed PMID:29793958 PubMed Central PMC6052313.
  22. Olson, ED, Musier-Forsyth, K. Retroviral Gag protein-RNA interactions: Implications for specific genomic RNA packaging and virion assembly. Semin Cell Dev Biol. 2019;86 :129-139. doi: 10.1016/j.semcdb.2018.03.015. PubMed PMID:29580971 PubMed Central PMC6167211.
  23. Song, Y, Zhou, H, Vo, MN, Shi, Y, Nawaz, MH, Vargas-Rodriguez, O et al.. Publisher Correction: Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid. Nat Commun. 2018;9 (1):1113. doi: 10.1038/s41467-018-03594-1. PubMed PMID:29535387 PubMed Central PMC5849694.
  24. Song, Y, Zhou, H, Vo, MN, Shi, Y, Nawaz, MH, Vargas-Rodriguez, O et al.. Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid. Nat Commun. 2017;8 (1):2281. doi: 10.1038/s41467-017-02201-z. PubMed PMID:29273753 PubMed Central PMC5741666.
  25. Comandur, R, Olson, ED, Musier-Forsyth, K. Conservation of tRNA mimicry in the 5'-untranslated region of distinct HIV-1 subtypes. RNA. 2017;23 (12):1850-1859. doi: 10.1261/rna.062182.117. PubMed PMID:28860303 PubMed Central PMC5689005.
  26. Duchon, AA, St Gelais, C, Titkemeier, N, Hatterschide, J, Wu, L, Musier-Forsyth, K et al.. HIV-1 Exploits a Dynamic Multi-aminoacyl-tRNA Synthetase Complex To Enhance Viral Replication. J Virol. 2017;91 (21):. doi: 10.1128/JVI.01240-17. PubMed PMID:28814526 PubMed Central PMC5640844.
  27. Danhart, EM, Bakhtina, M, Cantara, WA, Kuzmishin, AB, Ma, X, Sanford, BL et al.. Conformational and chemical selection by a trans-acting editing domain. Proc Natl Acad Sci U S A. 2017;114 (33):E6774-E6783. doi: 10.1073/pnas.1703925114. PubMed PMID:28768811 PubMed Central PMC5565427.
  28. Bacusmo, JM, Kuzmishin, AB, Cantara, WA, Goto, Y, Suga, H, Musier-Forsyth, K et al.. Quality control by trans-editing factor prevents global mistranslation of non-protein amino acid α-aminobutyrate. RNA Biol. 2018;15 (4-5):576-585. doi: 10.1080/15476286.2017.1353846. PubMed PMID:28737471 PubMed Central PMC6103672.
  29. Post, K, Olson, ED, Naufer, MN, Gorelick, RJ, Rouzina, I, Williams, MC et al.. Mechanistic differences between HIV-1 and SIV nucleocapsid proteins and cross-species HIV-1 genomic RNA recognition. Retrovirology. 2016;13 (1):89. doi: 10.1186/s12977-016-0322-5. PubMed PMID:28034301 PubMed Central PMC5198506.
  30. Todd, GC, Duchon, A, Inlora, J, Olson, ED, Musier-Forsyth, K, Ono, A et al.. Inhibition of HIV-1 Gag-membrane interactions by specific RNAs. RNA. 2017;23 (3):395-405. doi: 10.1261/rna.058453.116. PubMed PMID:27932583 PubMed Central PMC5311501.
  31. Liu, S, Comandur, R, Jones, CP, Tsang, P, Musier-Forsyth, K. Anticodon-like binding of the HIV-1 tRNA-like element to human lysyl-tRNA synthetase. RNA. 2016;22 (12):1828-1835. doi: 10.1261/rna.058081.116. PubMed PMID:27852925 PubMed Central PMC5113203.
  32. Cantara, WA, Hatterschide, J, Wu, W, Musier-Forsyth, K. RiboCAT: a new capillary electrophoresis data analysis tool for nucleic acid probing. RNA. 2017;23 (2):240-249. doi: 10.1261/rna.058404.116. PubMed PMID:27821510 PubMed Central PMC5238798.
  33. Cantara, WA, Olson, ED, Musier-Forsyth, K. Analysis of RNA structure using small-angle X-ray scattering. Methods. 2017;113 :46-55. doi: 10.1016/j.ymeth.2016.10.008. PubMed PMID:27777026 PubMed Central PMC5253320.
  34. Rye-McCurdy, T, Olson, ED, Liu, S, Binkley, C, Reyes, JP, Thompson, BR et al.. Functional Equivalence of Retroviral MA Domains in Facilitating Psi RNA Binding Specificity by Gag. Viruses. 2016;8 (9):. doi: 10.3390/v8090256. PubMed PMID:27657107 PubMed Central PMC5035970.
  35. Lomidze, L, Kelley, S, Gogichaishvili, S, Metreveli, N, Musier-Forsyth, K, Kankia, B et al.. Sr(2+) induces unusually stable d(GGGTGGGTGGGTGGG) quadruplex dimers. Biopolymers. 2016;105 (11):811-8. doi: 10.1002/bip.22916. PubMed PMID:27416320 .
  36. Kankia, B, Gvarjaladze, D, Rabe, A, Lomidze, L, Metreveli, N, Musier-Forsyth, K et al.. Stable Domain Assembly of a Monomolecular DNA Quadruplex: Implications for DNA-Based Nanoswitches. Biophys J. 2016;110 (10):2169-75. doi: 10.1016/j.bpj.2016.04.031. PubMed PMID:27224482 PubMed Central PMC4880955.
  37. McCauley, MJ, Rouzina, I, Manthei, KA, Gorelick, RJ, Musier-Forsyth, K, Williams, MC et al.. Targeted binding of nucleocapsid protein transforms the folding landscape of HIV-1 TAR RNA. Proc Natl Acad Sci U S A. 2015;112 (44):13555-60. doi: 10.1073/pnas.1510100112. PubMed PMID:26483503 PubMed Central PMC4640786.
  38. Olson, ED, Cantara, WA, Musier-Forsyth, K. New Structure Sheds Light on Selective HIV-1 Genomic RNA Packaging. Viruses. 2015;7 (8):4826-35. doi: 10.3390/v7082846. PubMed PMID:26305251 PubMed Central PMC4576207.
  39. Liu, Z, Vargas-Rodriguez, O, Goto, Y, Novoa, EM, Ribas de Pouplana, L, Suga, H et al.. Homologous trans-editing factors with broad tRNA specificity prevent mistranslation caused by serine/threonine misactivation. Proc Natl Acad Sci U S A. 2015;112 (19):6027-32. doi: 10.1073/pnas.1423664112. PubMed PMID:25918376 PubMed Central PMC4434731.
  40. Novoa, EM, Vargas-Rodriguez, O, Lange, S, Goto, Y, Suga, H, Musier-Forsyth, K et al.. Ancestral AlaX editing enzymes for control of genetic code fidelity are not tRNA-specific. J Biol Chem. 2015;290 (16):10495-503. doi: 10.1074/jbc.M115.640060. PubMed PMID:25724653 PubMed Central PMC4400357.
  41. Rye-McCurdy, T, Rouzina, I, Musier-Forsyth, K. Fluorescence anisotropy-based salt-titration approach to characterize protein-nucleic acid interactions. Methods Mol Biol. 2015;1259 :385-402. doi: 10.1007/978-1-4939-2214-7_23. PubMed PMID:25579598 .
  42. Berkhout, B, Mouland, AJ, Musier-Forsyth, K. Retroviral nucleocapsid protein and assembly. Foreword. Virus Res. 2014;193 :1. doi: 10.1016/j.virusres.2014.10.018. PubMed PMID:25440780 .
  43. Vargas-Rodriguez, O, Musier-Forsyth, K. Structural biology: wobble puts RNA on target. Nature. 2014;510 (7506):480-1. doi: 10.1038/nature13502. PubMed PMID:24919145 .
  44. Wu, H, Wang, W, Naiyer, N, Fichtenbaum, E, Qualley, DF, McCauley, MJ et al.. Single aromatic residue location alters nucleic acid binding and chaperone function of FIV nucleocapsid protein. Virus Res. 2014;193 :39-51. doi: 10.1016/j.virusres.2014.06.002. PubMed PMID:24915282 .
  45. Wang, W, Naiyer, N, Mitra, M, Li, J, Williams, MC, Rouzina, I et al.. Distinct nucleic acid interaction properties of HIV-1 nucleocapsid protein precursor NCp15 explain reduced viral infectivity. Nucleic Acids Res. 2014;42 (11):7145-59. doi: 10.1093/nar/gku335. PubMed PMID:24813443 .
  46. Alemán, EA, de Silva, C, Patrick, EM, Musier-Forsyth, K, Rueda, D. Single-Molecule Fluorescence Using Nucleotide Analogs: A Proof-of-Principle. J Phys Chem Lett. 2014;5 (5):777-781. doi: 10.1021/jz4025832. PubMed PMID:24803990 .
  47. Rye-McCurdy, TD, Nadaraia-Hoke, S, Gudleski-O'Regan, N, Flanagan, JM, Parent, LJ, Musier-Forsyth, K et al.. Mechanistic differences between nucleic acid chaperone activities of the Gag proteins of Rous sarcoma virus and human immunodeficiency virus type 1 are attributed to the MA domain. J Virol. 2014;88 (14):7852-61. doi: 10.1128/JVI.00736-14. PubMed PMID:24789780 .
  48. Qu, J, Kang, SG, Wang, W, Musier-Forsyth, K, Jang, JC. The Arabidopsis thaliana tandem zinc finger 1 (AtTZF1) protein in RNA binding and decay. Plant J. 2014;78 (3):452-67. doi: 10.1111/tpj.12485. PubMed PMID:24635033 .
  49. Jones, CP, Cantara, WA, Olson, ED, Musier-Forsyth, K. Small-angle X-ray scattering-derived structure of the HIV-1 5' UTR reveals 3D tRNA mimicry. Proc Natl Acad Sci U S A. 2014;111 (9):3395-400. doi: 10.1073/pnas.1319658111. PubMed PMID:24550473 .
  50. Bartholow, TG, Sanford, BL, Cao, B, Schmit, HL, Johnson, JM, Meitzner, J et al.. Strictly conserved lysine of prolyl-tRNA Synthetase editing domain facilitates binding and positioning of misacylated tRNA(Pro.). Biochemistry. 2014;53 (6):1059-68. doi: 10.1021/bi401279r. PubMed PMID:24450765 .
  51. Das, M, Vargas-Rodriguez, O, Goto, Y, Suga, H, Musier-Forsyth, K. Distinct tRNA recognition strategies used by a homologous family of editing domains prevent mistranslation. Nucleic Acids Res. 2014;42 (6):3943-53. doi: 10.1093/nar/gkt1332. PubMed PMID:24371276 .
  52. Chaurasiya, KR, McCauley, MJ, Wang, W, Qualley, DF, Wu, T, Kitamura, S et al.. Oligomerization transforms human APOBEC3G from an efficient enzyme to a slowly dissociating nucleic acid-binding protein. Nat Chem. 2014;6 (1):28-33. doi: 10.1038/nchem.1795. PubMed PMID:24345943 .
  53. Mathias, J, Okyere, R, Lomidze, L, Gvarjaladze, D, Musier-Forsyth, K, Kankia, B et al.. Thermal stability of quadruplex primers for highly versatile isothermal DNA amplification. Biophys Chem. 2014;185 :14-8. doi: 10.1016/j.bpc.2013.10.008. PubMed PMID:24317195 .
  54. Wu, H, Mitra, M, Naufer, MN, McCauley, MJ, Gorelick, RJ, Rouzina, I et al.. Differential contribution of basic residues to HIV-1 nucleocapsid protein's nucleic acid chaperone function and retroviral replication. Nucleic Acids Res. 2014;42 (4):2525-37. doi: 10.1093/nar/gkt1227. PubMed PMID:24293648 .
  55. Sun, M, Grigsby, IF, Gorelick, RJ, Mansky, LM, Musier-Forsyth, K. Retrovirus-specific differences in matrix and nucleocapsid protein-nucleic acid interactions: implications for genomic RNA packaging. J Virol. 2014;88 (2):1271-80. doi: 10.1128/JVI.02151-13. PubMed PMID:24227839 .
  56. Mitra, M, Wang, W, Vo, MN, Rouzina, I, Barany, G, Musier-Forsyth, K et al.. The N-terminal zinc finger and flanking basic domains represent the minimal region of the human immunodeficiency virus type-1 nucleocapsid protein for targeting chaperone function. Biochemistry. 2013;52 (46):8226-36. doi: 10.1021/bi401250a. PubMed PMID:24144434 .
  57. Webb, JA, Jones, CP, Parent, LJ, Rouzina, I, Musier-Forsyth, K. Distinct binding interactions of HIV-1 Gag to Psi and non-Psi RNAs: implications for viral genomic RNA packaging. RNA. 2013;19 (8):1078-88. doi: 10.1261/rna.038869.113. PubMed PMID:23798665 .
  58. Johnson, JM, Sanford, BL, Strom, AM, Tadayon, SN, Lehman, BP, Zirbes, AM et al.. Multiple pathways promote dynamical coupling between catalytic domains in Escherichia coli prolyl-tRNA synthetase. Biochemistry. 2013;52 (25):4399-412. doi: 10.1021/bi400079h. PubMed PMID:23731272 .
  59. Vargas-Rodriguez, O, Musier-Forsyth, K. Exclusive use of trans-editing domains prevents proline mistranslation. J Biol Chem. 2013;288 (20):14391-14399. doi: 10.1074/jbc.M113.467795. PubMed PMID:23564458 .
  60. Jones, CP, Saadatmand, J, Kleiman, L, Musier-Forsyth, K. Molecular mimicry of human tRNALys anti-codon domain by HIV-1 RNA genome facilitates tRNA primer annealing. RNA. 2013;19 (2):219-29. doi: 10.1261/rna.036681.112. PubMed PMID:23264568 .
  61. Taylor, A, Joseph, A, Okyere, R, Gogichaishvili, S, Musier-Forsyth, K, Kankia, B et al.. Isothermal quadruplex priming amplification for DNA-based diagnostics. Biophys Chem. 2013;171 :1-8. doi: 10.1016/j.bpc.2012.11.001. PubMed PMID:23232099 .
  62. Kumar, S, Das, M, Hadad, CM, Musier-Forsyth, K. Aminoacyl-tRNA substrate and enzyme backbone atoms contribute to translational quality control by YbaK. J Phys Chem B. 2013;117 (16):4521-7. doi: 10.1021/jp308628y. PubMed PMID:23185990 .
  63. Dewan, V, Wei, M, Kleiman, L, Musier-Forsyth, K. Dual role for motif 1 residues of human lysyl-tRNA synthetase in dimerization and packaging into HIV-1. J Biol Chem. 2012;287 (50):41955-62. doi: 10.1074/jbc.M112.421842. PubMed PMID:23095741 .
  64. Johnson, J, Okyere, R, Joseph, A, Musier-Forsyth, K, Kankia, B. Quadruplex formation as a molecular switch to turn on intrinsically fluorescent nucleotide analogs. Nucleic Acids Res. 2013;41 (1):220-8. doi: 10.1093/nar/gks975. PubMed PMID:23093597 .
  65. Wu, H, Mitra, M, McCauley, MJ, Thomas, JA, Rouzina, I, Musier-Forsyth, K et al.. Aromatic residue mutations reveal direct correlation between HIV-1 nucleocapsid protein's nucleic acid chaperone activity and retroviral replication. Virus Res. 2013;171 (2):263-77. doi: 10.1016/j.virusres.2012.07.008. PubMed PMID:22814429 .
  66. Wang, H, Musier-Forsyth, K, Falk, C, Barbara, PF. Single-molecule spectroscopic study of dynamic nanoscale DNA bending behavior of HIV-1 nucleocapsid protein. J Phys Chem B. 2013;117 (16):4183-96. doi: 10.1021/jp3018259. PubMed PMID:22591315 .
  67. Kumar, S, Das, M, Hadad, CM, Musier-Forsyth, K. Substrate and enzyme functional groups contribute to translational quality control by bacterial prolyl-tRNA synthetase. J Phys Chem B. 2012;116 (23):6991-9. doi: 10.1021/jp300845h. PubMed PMID:22458656 .
  68. Sanford, B, Cao, B, Johnson, JM, Zimmerman, K, Strom, AM, Mueller, RM et al.. Role of coupled dynamics in the catalytic activity of prokaryotic-like prolyl-tRNA synthetases. Biochemistry. 2012;51 (10):2146-56. doi: 10.1021/bi300097g. PubMed PMID:22356126 .
  69. Dewan, V, Liu, T, Chen, KM, Qian, Z, Xiao, Y, Kleiman, L et al.. Cyclic peptide inhibitors of HIV-1 capsid-human lysyl-tRNA synthetase interaction. ACS Chem Biol. 2012;7 (4):761-9. doi: 10.1021/cb200450w. PubMed PMID:22276994 .
  70. Kumar, S, Das, M, Hadad, CM, Musier-Forsyth, K. Substrate specificity of bacterial prolyl-tRNA synthetase editing domain is controlled by a tunable hydrophobic pocket. J Biol Chem. 2012;287 (5):3175-84. doi: 10.1074/jbc.M111.313619. PubMed PMID:22128149 .
  71. Kessl, JJ, Li, M, Ignatov, M, Shkriabai, N, Eidahl, JO, Feng, L et al.. FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75. Nucleic Acids Res. 2011;39 (20):9009-22. doi: 10.1093/nar/gkr581. PubMed PMID:21771857 PubMed Central PMC3203615.
  72. So, BR, An, S, Kumar, S, Das, M, Turner, DA, Hadad, CM et al.. Substrate-mediated fidelity mechanism ensures accurate decoding of proline codons. J Biol Chem. 2011;286 (36):31810-20. doi: 10.1074/jbc.M111.232611. PubMed PMID:21768119 PubMed Central PMC3173103.
  73. Rein, A, Datta, SA, Jones, CP, Musier-Forsyth, K. Diverse interactions of retroviral Gag proteins with RNAs. Trends Biochem Sci. 2011;36 (7):373-80. doi: 10.1016/j.tibs.2011.04.001. PubMed PMID:21550256 PubMed Central PMC3130074.
  74. Kelley, S, Boroda, S, Musier-Forsyth, K, Kankia, BI. HIV-integrase aptamer folds into a parallel quadruplex: a thermodynamic study. Biophys Chem. 2011;155 (2-3):82-8. doi: 10.1016/j.bpc.2011.03.004. PubMed PMID:21435774 .
  75. Musier-Forsyth, K. RNA remodeling by chaperones and helicases. RNA Biol. ;7 (6):632-3. doi: 10.4161/rna.7.6.14467. PubMed PMID:21173577 .
  76. Levin, JG, Mitra, M, Mascarenhas, A, Musier-Forsyth, K. Role of HIV-1 nucleocapsid protein in HIV-1 reverse transcription. RNA Biol. ;7 (6):754-74. doi: 10.4161/rna.7.6.14115. PubMed PMID:21160280 PubMed Central PMC3073334.
  77. Jones, CP, Datta, SA, Rein, A, Rouzina, I, Musier-Forsyth, K. Matrix domain modulates HIV-1 Gag's nucleic acid chaperone activity via inositol phosphate binding. J Virol. 2011;85 (4):1594-603. doi: 10.1128/JVI.01809-10. PubMed PMID:21123373 PubMed Central PMC3028911.
  78. Ranji, A, Shkriabai, N, Kvaratskhelia, M, Musier-Forsyth, K, Boris-Lawrie, K. Features of double-stranded RNA-binding domains of RNA helicase A are necessary for selective recognition and translation of complex mRNAs. J Biol Chem. 2011;286 (7):5328-37. doi: 10.1074/jbc.M110.176339. PubMed PMID:21123178 PubMed Central PMC3037645.
  79. Wang, H, Ma, X, Yeh, YS, Zhu, Y, Daugherty, MD, Frankel, AD et al.. Comparative analysis of RNA/protein dynamics for the arginine-rich-binding motif and zinc-finger-binding motif proteins encoded by HIV-1. Biophys J. 2010;99 (10):3454-62. doi: 10.1016/j.bpj.2010.09.051. PubMed PMID:21081095 PubMed Central PMC2980704.
  80. Kleiman, L, Jones, CP, Musier-Forsyth, K. Formation of the tRNALys packaging complex in HIV-1. FEBS Lett. 2010;584 (2):359-65. doi: 10.1016/j.febslet.2009.11.038. PubMed PMID:19914238 PubMed Central PMC2820394.
  81. Qualley, DF, Stewart-Maynard, KM, Wang, F, Mitra, M, Gorelick, RJ, Rouzina, I et al.. C-terminal domain modulates the nucleic acid chaperone activity of human T-cell leukemia virus type 1 nucleocapsid protein via an electrostatic mechanism. J Biol Chem. 2010;285 (1):295-307. doi: 10.1074/jbc.M109.051334. PubMed PMID:19887455 PubMed Central PMC2804176.
  82. Mascarenhas, AP, Musier-Forsyth, K. The capsid protein of human immunodeficiency virus: interactions of HIV-1 capsid with host protein factors. FEBS J. 2009;276 (21):6118-27. doi: 10.1111/j.1742-4658.2009.07315.x. PubMed PMID:19825046 .
  83. Ling, J, So, BR, Yadavalli, SS, Roy, H, Shoji, S, Fredrick, K et al.. Resampling and editing of mischarged tRNA prior to translation elongation. Mol Cell. 2009;33 (5):654-60. doi: 10.1016/j.molcel.2009.01.031. PubMed PMID:19285947 PubMed Central PMC2944653.
  84. Chen, Y, Wu, B, Musier-Forsyth, K, Mansky, LM, Mueller, JD. Fluorescence fluctuation spectroscopy on viral-like particles reveals variable gag stoichiometry. Biophys J. 2009;96 (5):1961-9. doi: 10.1016/j.bpj.2008.10.067. PubMed PMID:19254556 PubMed Central PMC2717261.
  85. Post, K, Kankia, B, Gopalakrishnan, S, Yang, V, Cramer, E, Saladores, P et al.. Fidelity of plus-strand priming requires the nucleic acid chaperone activity of HIV-1 nucleocapsid protein. Nucleic Acids Res. 2009;37 (6):1755-66. doi: 10.1093/nar/gkn1045. PubMed PMID:19158189 PubMed Central PMC2665208.
  86. Vo, MN, Barany, G, Rouzina, I, Musier-Forsyth, K. Effect of Mg(2+) and Na(+) on the nucleic acid chaperone activity of HIV-1 nucleocapsid protein: implications for reverse transcription. J Mol Biol. 2009;386 (3):773-88. doi: 10.1016/j.jmb.2008.12.073. PubMed PMID:19154740 PubMed Central PMC2642912.
  87. Vo, MN, Barany, G, Rouzina, I, Musier-Forsyth, K. HIV-1 nucleocapsid protein switches the pathway of transactivation response element RNA/DNA annealing from loop-loop "kissing" to "zipper". J Mol Biol. 2009;386 (3):789-801. doi: 10.1016/j.jmb.2008.12.070. PubMed PMID:19154737 PubMed Central PMC2646174.
  88. Yadavalli, SS, Musier-Forsyth, K, Ibba, M. The return of pretransfer editing in protein synthesis. Proc Natl Acad Sci U S A. 2008;105 (49):19031-2. doi: 10.1073/pnas.0810781106. PubMed PMID:19057010 PubMed Central PMC2614708.
  89. Wei, M, Yang, Y, Niu, M, Desfosse, L, Kennedy, R, Musier-Forsyth, K et al.. Inability of human immunodeficiency virus type 1 produced in murine cells to selectively incorporate primer formula. J Virol. 2008;82 (24):12049-59. doi: 10.1128/JVI.01744-08. PubMed PMID:18842718 PubMed Central PMC2593337.
  90. Stewart-Maynard, KM, Cruceanu, M, Wang, F, Vo, MN, Gorelick, RJ, Williams, MC et al.. Retroviral nucleocapsid proteins display nonequivalent levels of nucleic acid chaperone activity. J Virol. 2008;82 (20):10129-42. doi: 10.1128/JVI.01169-08. PubMed PMID:18684831 PubMed Central PMC2566285.
  91. Burke, B, An, S, Musier-Forsyth, K. Functional guanine-arginine interaction between tRNAPro and prolyl-tRNA synthetase that couples binding and catalysis. Biochim Biophys Acta. 2008;1784 (9):1222-5. doi: 10.1016/j.bbapap.2008.04.027. PubMed PMID:18513497 PubMed Central PMC2559941.
  92. An, S, Barany, G, Musier-Forsyth, K. Evolution of acceptor stem tRNA recognition by class II prolyl-tRNA synthetase. Nucleic Acids Res. 2008;36 (8):2514-21. doi: 10.1093/nar/gkn063. PubMed PMID:18310681 PubMed Central PMC2377447.
  93. Guo, M, Ignatov, M, Musier-Forsyth, K, Schimmel, P, Yang, XL. Crystal structure of tetrameric form of human lysyl-tRNA synthetase: Implications for multisynthetase complex formation. Proc Natl Acad Sci U S A. 2008;105 (7):2331-6. doi: 10.1073/pnas.0712072105. PubMed PMID:18272479 PubMed Central PMC2268136.
  94. Splan, KE, Musier-Forsyth, K, Boniecki, MT, Martinis, SA. In vitro assays for the determination of aminoacyl-tRNA synthetase editing activity. Methods. 2008;44 (2):119-28. doi: 10.1016/j.ymeth.2007.10.009. PubMed PMID:18241793 PubMed Central PMC2270698.
  95. Splan, KE, Ignatov, ME, Musier-Forsyth, K. Transfer RNA modulates the editing mechanism used by class II prolyl-tRNA synthetase. J Biol Chem. 2008;283 (11):7128-34. doi: 10.1074/jbc.M709902200. PubMed PMID:18180290 .
  96. Iwatani, Y, Chan, DS, Wang, F, Stewart-Maynard, K, Sugiura, W, Gronenborn, AM et al.. Deaminase-independent inhibition of HIV-1 reverse transcription by APOBEC3G. Nucleic Acids Res. 2007;35 (21):7096-108. doi: 10.1093/nar/gkm750. PubMed PMID:17942420 PubMed Central PMC2175344.
  97. Kovaleski, BJ, Kennedy, R, Khorchid, A, Kleiman, L, Matsuo, H, Musier-Forsyth, K et al.. Critical role of helix 4 of HIV-1 capsid C-terminal domain in interactions with human lysyl-tRNA synthetase. J Biol Chem. 2007;282 (44):32274-9. doi: 10.1074/jbc.M706256200. PubMed PMID:17724017 .
  98. Landes, CF, Zeng, Y, Liu, HW, Musier-Forsyth, K, Barbara, PF. Single-molecule study of the inhibition of HIV-1 transactivation response region DNA/DNA annealing by argininamide. J Am Chem Soc. 2007;129 (33):10181-8. doi: 10.1021/ja071491r. PubMed PMID:17658799 .
  99. Zeng, Y, Liu, HW, Landes, CF, Kim, YJ, Ma, X, Zhu, Y et al.. Probing nucleation, reverse annealing, and chaperone function along the reaction path of HIV-1 single-strand transfer. Proc Natl Acad Sci U S A. 2007;104 (31):12651-6. doi: 10.1073/pnas.0700350104. PubMed PMID:17578926 PubMed Central PMC1937521.
  100. Liu, HW, Zeng, Y, Landes, CF, Kim, YJ, Zhu, Y, Ma, X et al.. Insights on the role of nucleic acid/protein interactions in chaperoned nucleic acid rearrangements of HIV-1 reverse transcription. Proc Natl Acad Sci U S A. 2007;104 (13):5261-7. doi: 10.1073/pnas.0700166104. PubMed PMID:17372205 PubMed Central PMC1828707.
  101. SternJohn, J, Hati, S, Siliciano, PG, Musier-Forsyth, K. Restoring species-specific posttransfer editing activity to a synthetase with a defunct editing domain. Proc Natl Acad Sci U S A. 2007;104 (7):2127-32. doi: 10.1073/pnas.0611110104. PubMed PMID:17283340 PubMed Central PMC1892958.
  102. Kankia, BI, Musier-Forsyth, K. The HIV-1 central DNA flap region contains a "flapping" third strand. Biophys Chem. 2007;127 (1-2):64-8. doi: 10.1016/j.bpc.2006.12.005. PubMed PMID:17215070 .
  103. Cruceanu, M, Gorelick, RJ, Musier-Forsyth, K, Rouzina, I, Williams, MC. Rapid kinetics of protein-nucleic acid interaction is a major component of HIV-1 nucleocapsid protein's nucleic acid chaperone function. J Mol Biol. 2006;363 (5):867-77. doi: 10.1016/j.jmb.2006.08.070. PubMed PMID:16997322 .
  104. Vo, MN, Barany, G, Rouzina, I, Musier-Forsyth, K. Mechanistic studies of mini-TAR RNA/DNA annealing in the absence and presence of HIV-1 nucleocapsid protein. J Mol Biol. 2006;363 (1):244-61. doi: 10.1016/j.jmb.2006.08.039. PubMed PMID:16962137 .
  105. Hati, S, Ziervogel, B, Sternjohn, J, Wong, FC, Nagan, MC, Rosen, AE et al.. Pre-transfer editing by class II prolyl-tRNA synthetase: role of aminoacylation active site in "selective release" of noncognate amino acids. J Biol Chem. 2006;281 (38):27862-72. doi: 10.1074/jbc.M605856200. PubMed PMID:16864571 .
  106. Rosen, AE, Brooks, BS, Guth, E, Francklyn, CS, Musier-Forsyth, K. Evolutionary conservation of a functionally important backbone phosphate group critical for aminoacylation of histidine tRNAs. RNA. 2006;12 (7):1315-22. doi: 10.1261/rna.78606. PubMed PMID:16741232 PubMed Central PMC1484442.
  107. Kovaleski, BJ, Kennedy, R, Hong, MK, Datta, SA, Kleiman, L, Rein, A et al.. In vitro characterization of the interaction between HIV-1 Gag and human lysyl-tRNA synthetase. J Biol Chem. 2006;281 (28):19449-56. doi: 10.1074/jbc.M601189200. PubMed PMID:16702215 .
  108. Cosa, G, Zeng, Y, Liu, HW, Landes, CF, Makarov, DE, Musier-Forsyth, K et al.. Evidence for non-two-state kinetics in the nucleocapsid protein chaperoned opening of DNA hairpins. J Phys Chem B. 2006;110 (5):2419-26. doi: 10.1021/jp054189i. PubMed PMID:16471833 .
  109. Pinto, YY, Le, JD, Seeman, NC, Musier-Forsyth, K, Taton, TA, Kiehl, RA et al.. Sequence-encoded self-assembly of multiple-nanocomponent arrays by 2D DNA scaffolding. Nano Lett. 2005;5 (12):2399-402. doi: 10.1021/nl0515495. PubMed PMID:16351185 .
  110. Levin, JG, Guo, J, Rouzina, I, Musier-Forsyth, K. Nucleic acid chaperone activity of HIV-1 nucleocapsid protein: critical role in reverse transcription and molecular mechanism. Prog Nucleic Acid Res Mol Biol. 2005;80 :217-86. doi: 10.1016/S0079-6603(05)80006-6. PubMed PMID:16164976 .
  111. Liu, HW, Cosa, G, Landes, CF, Zeng, Y, Kovaleski, BJ, Mullen, DG et al.. Single-molecule FRET studies of important intermediates in the nucleocapsid-protein-chaperoned minus-strand transfer step in HIV-1 reverse transcription. Biophys J. 2005;89 (5):3470-9. doi: 10.1529/biophysj.105.065326. PubMed PMID:16100256 PubMed Central PMC1366842.
  112. An, S, Musier-Forsyth, K. Cys-tRNA(Pro) editing by Haemophilus influenzae YbaK via a novel synthetase.YbaK.tRNA ternary complex. J Biol Chem. 2005;280 (41):34465-72. doi: 10.1074/jbc.M507550200. PubMed PMID:16087664 .
  113. Kankia, BI, Barany, G, Musier-Forsyth, K. Unfolding of DNA quadruplexes induced by HIV-1 nucleocapsid protein. Nucleic Acids Res. 2005;33 (14):4395-403. doi: 10.1093/nar/gki741. PubMed PMID:16077025 PubMed Central PMC1182697.
  114. Cosa, G, Harbron, EJ, Zeng, Y, Liu, HW, O'Connor, DB, Eta-Hosokawa, C et al.. Secondary structure and secondary structure dynamics of DNA hairpins complexed with HIV-1 NC protein. Biophys J. 2004;87 (4):2759-67. doi: 10.1529/biophysj.104.043083. PubMed PMID:15454467 PubMed Central PMC1304694.
  115. An, S, Musier-Forsyth, K. Trans-editing of Cys-tRNAPro by Haemophilus influenzae YbaK protein. J Biol Chem. 2004;279 (41):42359-62. doi: 10.1074/jbc.C400304200. PubMed PMID:15322138 .
  116. Gunasekera, N, Lee, SW, Kim, S, Musier-Forsyth, K, Arriaga, E. Nuclear localization of aminoacyl-tRNA synthetases using single-cell capillary electrophoresis laser-induced fluorescence analysis. Anal Chem. 2004;76 (16):4741-6. doi: 10.1021/ac049567e. PubMed PMID:15307785 .
  117. Gunasekera, N, Xiong, G, Musier-Forsyth, K, Arriaga, E. A capillary electrophoretic method for monitoring the presence of alpha-tubulin in nuclear preparations. Anal Biochem. 2004;330 (1):1-9. doi: 10.1016/j.ab.2004.03.059. PubMed PMID:15183755 .
  118. Hargittai, MR, Gorelick, RJ, Rouzina, I, Musier-Forsyth, K. Mechanistic insights into the kinetics of HIV-1 nucleocapsid protein-facilitated tRNA annealing to the primer binding site. J Mol Biol. 2004;337 (4):951-68. doi: 10.1016/j.jmb.2004.01.054. PubMed PMID:15033363 .
  119. Gunasekera, N, Olson, KJ, Musier-Forsyth, K, Arriaga, EA. Capillary electrophoretic separation of nuclei released from single cells. Anal Chem. 2004;76 (3):655-62. doi: 10.1021/ac034916a. PubMed PMID:14750860 .
  120. Connolly, SA, Rosen, AE, Musier-Forsyth, K, Francklyn, CS. G-1:C73 recognition by an arginine cluster in the active site of Escherichia coli histidyl-tRNA synthetase. Biochemistry. 2004;43 (4):962-9. doi: 10.1021/bi035708f. PubMed PMID:14744140 .
  121. Rosen, AE, Musier-Forsyth, K. Recognition of G-1:C73 atomic groups by Escherichia coli histidyl-tRNA synthetase. J Am Chem Soc. 2004;126 (1):64-5. doi: 10.1021/ja0381609. PubMed PMID:14709061 .
  122. Seetharaman, M, Williams, C, Cramer, CJ, Musier-Forsyth, K. Effect of G-1 on histidine tRNA microhelix conformation. Nucleic Acids Res. 2003;31 (24):7311-21. doi: 10.1093/nar/gkg930. PubMed PMID:14654706 PubMed Central PMC291870.
  123. Wong, FC, Beuning, PJ, Silvers, C, Musier-Forsyth, K. An isolated class II aminoacyl-tRNA synthetase insertion domain is functional in amino acid editing. J Biol Chem. 2003;278 (52):52857-64. doi: 10.1074/jbc.M309627200. PubMed PMID:14530268 .
  124. Lee, N, Gorelick, RJ, Musier-Forsyth, K. Zinc finger-dependent HIV-1 nucleocapsid protein-TAR RNA interactions. Nucleic Acids Res. 2003;31 (16):4847-55. doi: 10.1093/nar/gkg679. PubMed PMID:12907727 PubMed Central PMC169955.
  125. Khandogin, J, Musier-Forsyth, K, York, DM. Insights into the regioselectivity and RNA-binding affinity of HIV-1 nucleocapsid protein from linear-scaling quantum methods. J Mol Biol. 2003;330 (5):993-1004. doi: 10.1016/s0022-2836(03)00658-2. PubMed PMID:12860122 .
  126. Javanbakht, H, Halwani, R, Cen, S, Saadatmand, J, Musier-Forsyth, K, Gottlinger, H et al.. The interaction between HIV-1 Gag and human lysyl-tRNA synthetase during viral assembly. J Biol Chem. 2003;278 (30):27644-51. doi: 10.1074/jbc.M301840200. PubMed PMID:12756246 .
  127. Iwatani, Y, Rosen, AE, Guo, J, Musier-Forsyth, K, Levin, JG. Efficient initiation of HIV-1 reverse transcription in vitro. Requirement for RNA sequences downstream of the primer binding site abrogated by nucleocapsid protein-dependent primer-template interactions. J Biol Chem. 2003;278 (16):14185-95. doi: 10.1074/jbc.M211618200. PubMed PMID:12560327 .
  128. Hong, MK, Harbron, EJ, O'Connor, DB, Guo, J, Barbara, PF, Levin, JG et al.. Nucleic acid conformational changes essential for HIV-1 nucleocapsid protein-mediated inhibition of self-priming in minus-strand transfer. J Mol Biol. 2003;325 (1):1-10. doi: 10.1016/s0022-2836(02)01177-4. PubMed PMID:12473448 .
  129. Cen, S, Javanbakht, H, Kim, S, Shiba, K, Craven, R, Rein, A et al.. Retrovirus-specific packaging of aminoacyl-tRNA synthetases with cognate primer tRNAs. J Virol. 2002;76 (24):13111-5. doi: 10.1128/jvi.76.24.13111-13115.2002. PubMed PMID:12438642 PubMed Central PMC136713.
  130. Gunasekera, N, Musier-Forsyth, K, Arriaga, E. Electrophoretic behavior of individual nuclear species as determined by capillary electrophoresis with laser-induced fluorescence detection. Electrophoresis. 2002;23 (13):2110-6. doi: 10.1002/1522-2683(200207)23:13<2110::AID-ELPS2110>3.0.CO;2-3. PubMed PMID:12210266 .
  131. Williams, MC, Gorelick, RJ, Musier-Forsyth, K. Specific zinc-finger architecture required for HIV-1 nucleocapsid protein's nucleic acid chaperone function. Proc Natl Acad Sci U S A. 2002;99 (13):8614-9. doi: 10.1073/pnas.132128999. PubMed PMID:12084921 PubMed Central PMC124332.
  132. Wong, FC, Beuning, PJ, Nagan, M, Shiba, K, Musier-Forsyth, K. Functional role of the prokaryotic proline-tRNA synthetase insertion domain in amino acid editing. Biochemistry. 2002;41 (22):7108-15. doi: 10.1021/bi012178j. PubMed PMID:12033945 .
  133. Beuning, PJ, Nagan, MC, Cramer, CJ, Musier-Forsyth, K, Gelpí, JL, Bashford, D et al.. Efficient aminoacylation of the tRNA(Ala) acceptor stem: dependence on the 2:71 base pair. RNA. 2002;8 (5):659-70. doi: 10.1017/s1355838202020277. PubMed PMID:12022232 PubMed Central PMC1370286.
  134. Javanbakht, H, Cen, S, Musier-Forsyth, K, Kleiman, L. Correlation between tRNALys3 aminoacylation and its incorporation into HIV-1. J Biol Chem. 2002;277 (20):17389-96. doi: 10.1074/jbc.M112479200. PubMed PMID:11884398 .
  135. Lipman, RS, Beuning, PJ, Musier-Forsyth, K, Hou, YM. Amino acid activation of a dual-specificity tRNA synthetase is independent of tRNA. J Mol Biol. 2002;316 (3):421-7. doi: 10.1006/jmbi.2001.5373. PubMed PMID:11866507 .
  136. Hargittai, MR, Mangla, AT, Gorelick, RJ, Musier-Forsyth, K. HIV-1 nucleocapsid protein zinc finger structures induce tRNA(Lys,3) structural changes but are not critical for primer/template annealing. J Mol Biol. 2001;312 (5):985-97. doi: 10.1006/jmbi.2001.5021. PubMed PMID:11580244 .
  137. Beuning, PJ, Musier-Forsyth, K. Species-specific differences in amino acid editing by class II prolyl-tRNA synthetase. J Biol Chem. 2001;276 (33):30779-85. doi: 10.1074/jbc.M104761200. PubMed PMID:11408489 .
  138. Williams, MC, Rouzina, I, Wenner, JR, Gorelick, RJ, Musier-Forsyth, K, Bloomfield, VA et al.. Mechanism for nucleic acid chaperone activity of HIV-1 nucleocapsid protein revealed by single molecule stretching. Proc Natl Acad Sci U S A. 2001;98 (11):6121-6. doi: 10.1073/pnas.101033198. PubMed PMID:11344257 PubMed Central PMC33432.
  139. Burke, B, Lipman, RS, Shiba, K, Musier-Forsyth, K, Hou, YM. Divergent adaptation of tRNA recognition by Methanococcus jannaschii prolyl-tRNA synthetase. J Biol Chem. 2001;276 (23):20286-91. doi: 10.1074/jbc.m100456200. PubMed PMID:11342535 .
  140. Cen, S, Khorchid, A, Javanbakht, H, Gabor, J, Stello, T, Shiba, K et al.. Incorporation of lysyl-tRNA synthetase into human immunodeficiency virus type 1. J Virol. 2001;75 (11):5043-8. doi: 10.1128/JVI.75.11.5043-5048.2001. PubMed PMID:11333884 PubMed Central PMC114908.
  141. Burke, B, Yang, F, Chen, F, Stehlin, C, Chan, B, Musier-Forsyth, K et al.. Evolutionary coadaptation of the motif 2--acceptor stem interaction in the class II prolyl-tRNA synthetase system. Biochemistry. 2000;39 (50):15540-7. doi: 10.1021/bi001835p. PubMed PMID:11112540 .
  142. Hargittai, MR, Musier-Forsyth, K. Use of terbium as a probe of tRNA tertiary structure and folding. RNA. 2000;6 (11):1672-80. doi: 10.1017/s135583820000128x. PubMed PMID:11105765 PubMed Central PMC1370035.
  143. Beuning, PJ, Musier-Forsyth, K. Hydrolytic editing by a class II aminoacyl-tRNA synthetase. Proc Natl Acad Sci U S A. 2000;97 (16):8916-20. doi: 10.1073/pnas.97.16.8916. PubMed PMID:10922054 PubMed Central PMC16796.
  144. Musier-Forsyth, K, Beuning, PJ. Role of zinc ion in translational accuracy becomes crystal clear. Nat Struct Biol. 2000;7 (6):435-6. doi: 10.1038/75816. PubMed PMID:10881182 .
  145. Nagan, MC, Beuning, P, Musier-Forsyth, K, Cramer, CJ. Importance of discriminator base stacking interactions: molecular dynamics analysis of A73 microhelix(Ala) variants. Nucleic Acids Res. 2000;28 (13):2527-34. doi: 10.1093/nar/28.13.2527. PubMed PMID:10871402 PubMed Central PMC102696.
  146. Beuning, PJ, Musier-Forsyth, K. Transfer RNA recognition by aminoacyl-tRNA synthetases. Biopolymers. 1999;52 (1):1-28. doi: 10.1002/(SICI)1097-0282(1999)52:1<1::AID-BIP1>3.0.CO;2-W. PubMed PMID:10737860 .
  147. Fischer, AE, Beuning, PJ, Musier-Forsyth, K. Identification of discriminator base atomic groups that modulate the alanine aminoacylation reaction. J Biol Chem. 1999;274 (52):37093-6. doi: 10.1074/jbc.274.52.37093. PubMed PMID:10601268 .
  148. Stello, T, Hong, M, Musier-Forsyth, K. Efficient aminoacylation of tRNA(Lys,3) by human lysyl-tRNA synthetase is dependent on covalent continuity between the acceptor stem and the anticodon domain. Nucleic Acids Res. 1999;27 (24):4823-9. doi: 10.1093/nar/27.24.4823. PubMed PMID:10572184 PubMed Central PMC148784.
  149. Beuning, PJ, Tessmer, MR, Baumann, CG, Kallick, DA, Musier-Forsyth, K. Sequence-dependent conformational differences of small RNAs revealed by native gel electrophoresis. Anal Biochem. 1999;273 (2):284-90. doi: 10.1006/abio.1999.4223. PubMed PMID:10469499 .
  150. Chan, B, Weidemaier, K, Yip, WT, Barbara, PF, Musier-Forsyth, K. Intra-tRNA distance measurements for nucleocapsid proteindependent tRNA unwinding during priming of HIV reverse transcription. Proc Natl Acad Sci U S A. 1999;96 (2):459-64. doi: 10.1073/pnas.96.2.459. PubMed PMID:9892655 PubMed Central PMC15158.
  151. Stehlin, C, Burke, B, Yang, F, Liu, H, Shiba, K, Musier-Forsyth, K et al.. Species-specific differences in the operational RNA code for aminoacylation of tRNAPro. Biochemistry. 1998;37 (23):8605-13. doi: 10.1021/bi980364s. PubMed PMID:9622512 .
  152. Chan, B, Musier-Forsyth, K. The nucleocapsid protein specifically anneals tRNALys-3 onto a noncomplementary primer binding site within the HIV-1 RNA genome in vitro. Proc Natl Acad Sci U S A. 1997;94 (25):13530-5. doi: 10.1073/pnas.94.25.13530. PubMed PMID:9391060 PubMed Central PMC28340.
  153. Beuning, PJ, Yang, F, Schimmel, P, Musier-Forsyth, K. Specific atomic groups and RNA helix geometry in acceptor stem recognition by a tRNA synthetase. Proc Natl Acad Sci U S A. 1997;94 (19):10150-4. doi: 10.1073/pnas.94.19.10150. PubMed PMID:9294178 PubMed Central PMC23330.
  154. Francklyn, C, Musier-Forsyth, K, Martinis, SA. Aminoacyl-tRNA synthetases in biology and disease: new evidence for structural and functional diversity in an ancient family of enzymes. RNA. 1997;3 (9):954-60. . PubMed PMID:9292495 PubMed Central PMC1369542.
  155. Shiba, K, Stello, T, Motegi, H, Noda, T, Musier-Forsyth, K, Schimmel, P et al.. Human lysyl-tRNA synthetase accepts nucleotide 73 variants and rescues Escherichia coli double-defective mutant. J Biol Chem. 1997;272 (36):22809-16. doi: 10.1074/jbc.272.36.22809. PubMed PMID:9278442 .
  156. Stehlin, C, Heacock, DH 2nd, Liu, H, Musier-Forsyth, K. Chemical modification and site-directed mutagenesis of the single cysteine in motif 3 of class II Escherichia coli prolyl-tRNA synthetase. Biochemistry. 1997;36 (10):2932-8. doi: 10.1021/bi962295s. PubMed PMID:9062123 .
  157. Musier-Forsyth, K, Stehlin, C, Burke, B, Liu, H. Understanding species-specific differences in substrate recognition by Escherichia coli and human prolyl-tRNA synthetases. Nucleic Acids Symp Ser. 1997; (36):5-7. . PubMed PMID:9478190 .
  158. Schimmel, P, Musier-Forsyth, K. 'Distorted' RNA helix recognition. Nature. 1996;384 (6608):422. doi: 10.1038/384422a0. PubMed PMID:8945467 .
  159. Xu, Q, Barany, G, Hammer, RP, Musier-Forsyth, K. Efficient introduction of phosphorothioates into RNA oligonucleotides by 3-ethoxy-1,2,4-dithiazoline-5-one (EDITH). Nucleic Acids Res. 1996;24 (18):3643-4. doi: 10.1093/nar/24.18.3643. PubMed PMID:8836195 PubMed Central PMC146137.
  160. Xu, Q, Musier-Forsyth, K, Hammer, RP, Barany, G. Use of 1,2,4-dithiazolidine-3,5-dione (DtsNH) and 3-ethoxy-1,2,4-dithiazoline-5-one (EDITH) for synthesis of phosphorothioate-containing oligodeoxyribonucleotides. Nucleic Acids Res. 1996;24 (9):1602-7. doi: 10.1093/nar/24.9.1602. PubMed PMID:8649975 PubMed Central PMC145860.
  161. Yap, LP, Stehlin, C, Musier-Forsyth, K. Use of semi-synthetic transfer RNAs to probe molecular recognition by Escherichia coli proline-tRNA synthetase. Chem Biol. 1995;2 (10):661-6. doi: 10.1016/1074-5521(95)90029-2. PubMed PMID:9383472 .
  162. Liu, H, Kessler, J, Peterson, R, Musier-Forsyth, K. Evidence for class-specific discrimination of a semiconserved base pair by tRNA synthetases. Biochemistry. 1995;34 (30):9795-800. doi: 10.1021/bi00030a017. PubMed PMID:7542924 .
  163. Yap, LP, Musier-Forsyth, K. Transfer RNA aminoacylation: identification of a critical ribose 2'-hydroxyl-base interaction. RNA. 1995;1 (4):418-24. . PubMed PMID:7493319 PubMed Central PMC1482412.
  164. Liu, H, Peterson, R, Kessler, J, Musier-Forsyth, K. Molecular recognition of tRNA(Pro) by Escherichia coli proline tRNA synthetase in vitro. Nucleic Acids Res. 1995;23 (1):165-9. doi: 10.1093/nar/23.1.165. PubMed PMID:7870582 PubMed Central PMC306645.
  165. Liu, H, Yap, LP, Stehlin, C, Musier-Forsyth, K. Molecular recognition of tRNA(Pro) by Escherichia coli proline-tRNA synthetase. Nucleic Acids Symp Ser. 1995; (33):176-8. . PubMed PMID:8643363 .
  166. Liu, H, Musier-Forsyth, K. Escherichia coli proline tRNA synthetase is sensitive to changes in the core region of tRNA(Pro). Biochemistry. 1994;33 (42):12708-14. doi: 10.1021/bi00208a023. PubMed PMID:7522561 .
  167. Davis, MW, Buechter, DD, Schimmel, P. Functional dissection of a predicted class-defining motif in a class II tRNA synthetase of unknown structure. Biochemistry. 1994;33 (33):9904-11. doi: 10.1021/bi00199a012. PubMed PMID:8060998 .
  168. Shi, JP, Musier-Forsyth, K, Schimmel, P. Region of a conserved sequence motif in a class II tRNA synthetase needed for transfer of an activated amino acid to an RNA substrate. Biochemistry. 1994;33 (17):5312-8. doi: 10.1021/bi00183a039. PubMed PMID:8172905 .
  169. Musier-Forsyth, K, Schimmel, P. Acceptor helix interactions in a class II tRNA synthetase: photoaffinity cross-linking of an RNA miniduplex substrate. Biochemistry. 1994;33 (3):773-9. doi: 10.1021/bi00169a019. PubMed PMID:8292605 .
  170. Musier-Forsyth, K, Schimmel, P. Aminoacylation of RNA oligonucleotides: minimalist structures and origin of specificity. FASEB J. 1993;7 (2):282-9. doi: 10.1096/fasebj.7.2.7680012. PubMed PMID:7680012 .
  171. Sarih-Cottin, L, Bordier, B, Musier-Forsyth, K, Andreola, ML, Barr, PJ, Litvak, S et al.. Preferential interaction of human immunodeficiency virus reverse transcriptase with two regions of primer tRNA(Lys) as evidenced by footprinting studies and inhibition with synthetic oligoribonucleotides. J Mol Biol. 1992;226 (1):1-6. doi: 10.1016/0022-2836(92)90117-3. PubMed PMID:1377751 .
  172. Musier-Forsyth, K, Schimmel, P. Functional contacts of a transfer RNA synthetase with 2'-hydroxyl groups in the RNA minor groove. Nature. 1992;357 (6378):513-5. doi: 10.1038/357513a0. PubMed PMID:1608452 .
  173. Francklyn, C, Musier-Forsyth, K, Schimmel, P. Small RNA helices as substrates for aminoacylation and their relationship to charging of transfer RNAs. Eur J Biochem. 1992;206 (2):315-21. doi: 10.1111/j.1432-1033.1992.tb16929.x. PubMed PMID:1375910 .
  174. Musier-Forsyth, K, Usman, N, Scaringe, S, Doudna, J, Green, R, Schimmel, P et al.. Specificity for aminoacylation of an RNA helix: an unpaired, exocyclic amino group in the minor groove. Science. 1991;253 (5021):784-6. doi: 10.1126/science.1876835. PubMed PMID:1876835 .
  175. Musier-Forsyth, K, Scaringe, S, Usman, N, Schimmel, P. Enzymatic aminoacylation of single-stranded RNA with an RNA cofactor. Proc Natl Acad Sci U S A. 1991;88 (1):209-13. doi: 10.1073/pnas.88.1.209. PubMed PMID:1986368 PubMed Central PMC50779.
  176. Musier-Forsyth, KM, Hammes, GG. Rotational dynamics of chloroplast ATP synthase in phospholipid vesicles. Biochemistry. 1990;29 (13):3236-41. doi: 10.1021/bi00465a014. PubMed PMID:2159333 .
Search PubMed

Recent Posts