Musier-Forsyth Publications

  1. Wu, W, Hatterschide, J, Syu, YC, Cantara, WA, Blower, RJ, Hanson, HM et al.. Human T-cell leukemia virus type 1 Gag domains have distinct RNA-binding specificities with implications for RNA packaging and dimerization. J. Biol. Chem. 2018;293 (42):16261-16276. doi: 10.1074/jbc.RA118.005531. PubMed PMID:30217825 PubMed Central PMC6200928.
  2. Dayeh, DM, Cantara, WA, Kitzrow, JP, Musier-Forsyth, K, Nakanishi, K. Argonaute-based programmable RNase as a tool for cleavage of highly-structured RNA. Nucleic Acids Res. 2018;46 (16):e98. doi: 10.1093/nar/gky496. PubMed PMID:29897478 PubMed Central PMC6144825.
  3. Antonucci, JM, Kim, SH, St Gelais, C, Bonifati, S, Li, TW, Buzovetsky, O et al.. SAMHD1 Impairs HIV-1 Gene Expression and Negatively Modulates Reactivation of Viral Latency in CD4 T Cells. J. Virol. 2018;92 (15):. doi: 10.1128/JVI.00292-18. PubMed PMID:29793958 PubMed Central PMC6052313.
  4. Olson, ED, Musier-Forsyth, K. Retroviral Gag protein-RNA interactions: Implications for specific genomic RNA packaging and virion assembly. Semin. Cell Dev. Biol. 2018; :. doi: 10.1016/j.semcdb.2018.03.015. PubMed PMID:29580971 PubMed Central PMC6167211.
  5. Song, Y, Zhou, H, Vo, MN, Shi, Y, Nawaz, MH, Vargas-Rodriguez, O et al.. Publisher Correction: Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid. Nat Commun. 2018;9 (1):1113. doi: 10.1038/s41467-018-03594-1. PubMed PMID:29535387 PubMed Central PMC5849694.
  6. Song, Y, Zhou, H, Vo, MN, Shi, Y, Nawaz, MH, Vargas-Rodriguez, O et al.. Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid. Nat Commun. 2017;8 (1):2281. doi: 10.1038/s41467-017-02201-z. PubMed PMID:29273753 PubMed Central PMC5741666.
  7. Comandur, R, Olson, ED, Musier-Forsyth, K. Conservation of tRNA mimicry in the 5'-untranslated region of distinct HIV-1 subtypes. RNA. 2017;23 (12):1850-1859. doi: 10.1261/rna.062182.117. PubMed PMID:28860303 PubMed Central PMC5689005.
  8. Duchon, AA, St Gelais, C, Titkemeier, N, Hatterschide, J, Wu, L, Musier-Forsyth, K et al.. HIV-1 Exploits a Dynamic Multi-aminoacyl-tRNA Synthetase Complex To Enhance Viral Replication. J. Virol. 2017;91 (21):. doi: 10.1128/JVI.01240-17. PubMed PMID:28814526 PubMed Central PMC5640844.
  9. Danhart, EM, Bakhtina, M, Cantara, WA, Kuzmishin, AB, Ma, X, Sanford, BL et al.. Conformational and chemical selection by a -acting editing domain. Proc. Natl. Acad. Sci. U.S.A. 2017;114 (33):E6774-E6783. doi: 10.1073/pnas.1703925114. PubMed PMID:28768811 PubMed Central PMC5565427.
  10. Bacusmo, JM, Kuzmishin, AB, Cantara, WA, Goto, Y, Suga, H, Musier-Forsyth, K et al.. Quality control by trans-editing factor prevents global mistranslation of non-protein amino acid α-aminobutyrate. RNA Biol. 2018;15 (4-5):576-585. doi: 10.1080/15476286.2017.1353846. PubMed PMID:28737471 PubMed Central PMC6103672.
  11. Post, K, Olson, ED, Naufer, MN, Gorelick, RJ, Rouzina, I, Williams, MC et al.. Mechanistic differences between HIV-1 and SIV nucleocapsid proteins and cross-species HIV-1 genomic RNA recognition. Retrovirology. 2016;13 (1):89. doi: 10.1186/s12977-016-0322-5. PubMed PMID:28034301 PubMed Central PMC5198506.
  12. Todd, GC, Duchon, A, Inlora, J, Olson, ED, Musier-Forsyth, K, Ono, A et al.. Inhibition of HIV-1 Gag-membrane interactions by specific RNAs. RNA. 2017;23 (3):395-405. doi: 10.1261/rna.058453.116. PubMed PMID:27932583 PubMed Central PMC5311501.
  13. Liu, S, Comandur, R, Jones, CP, Tsang, P, Musier-Forsyth, K. Anticodon-like binding of the HIV-1 tRNA-like element to human lysyl-tRNA synthetase. RNA. 2016;22 (12):1828-1835. doi: 10.1261/rna.058081.116. PubMed PMID:27852925 PubMed Central PMC5113203.
  14. Cantara, WA, Hatterschide, J, Wu, W, Musier-Forsyth, K. RiboCAT: a new capillary electrophoresis data analysis tool for nucleic acid probing. RNA. 2017;23 (2):240-249. doi: 10.1261/rna.058404.116. PubMed PMID:27821510 PubMed Central PMC5238798.
  15. Cantara, WA, Olson, ED, Musier-Forsyth, K. Analysis of RNA structure using small-angle X-ray scattering. Methods. 2017;113 :46-55. doi: 10.1016/j.ymeth.2016.10.008. PubMed PMID:27777026 PubMed Central PMC5253320.
  16. Rye-McCurdy, T, Olson, ED, Liu, S, Binkley, C, Reyes, JP, Thompson, BR et al.. Functional Equivalence of Retroviral MA Domains in Facilitating Psi RNA Binding Specificity by Gag. Viruses. 2016;8 (9):. doi: 10.3390/v8090256. PubMed PMID:27657107 PubMed Central PMC5035970.
  17. Lomidze, L, Kelley, S, Gogichaishvili, S, Metreveli, N, Musier-Forsyth, K, Kankia, B et al.. Sr(2+) induces unusually stable d(GGGTGGGTGGGTGGG) quadruplex dimers. Biopolymers. 2016;105 (11):811-8. doi: 10.1002/bip.22916. PubMed PMID:27416320 .
  18. Kankia, B, Gvarjaladze, D, Rabe, A, Lomidze, L, Metreveli, N, Musier-Forsyth, K et al.. Stable Domain Assembly of a Monomolecular DNA Quadruplex: Implications for DNA-Based Nanoswitches. Biophys. J. 2016;110 (10):2169-75. doi: 10.1016/j.bpj.2016.04.031. PubMed PMID:27224482 PubMed Central PMC4880955.
  19. McCauley, MJ, Rouzina, I, Manthei, KA, Gorelick, RJ, Musier-Forsyth, K, Williams, MC et al.. Targeted binding of nucleocapsid protein transforms the folding landscape of HIV-1 TAR RNA. Proc. Natl. Acad. Sci. U.S.A. 2015;112 (44):13555-60. doi: 10.1073/pnas.1510100112. PubMed PMID:26483503 PubMed Central PMC4640786.
  20. Olson, ED, Cantara, WA, Musier-Forsyth, K. New Structure Sheds Light on Selective HIV-1 Genomic RNA Packaging. Viruses. 2015;7 (8):4826-35. doi: 10.3390/v7082846. PubMed PMID:26305251 PubMed Central PMC4576207.
  21. Liu, Z, Vargas-Rodriguez, O, Goto, Y, Novoa, EM, Ribas de Pouplana, L, Suga, H et al.. Homologous trans-editing factors with broad tRNA specificity prevent mistranslation caused by serine/threonine misactivation. Proc. Natl. Acad. Sci. U.S.A. 2015;112 (19):6027-32. doi: 10.1073/pnas.1423664112. PubMed PMID:25918376 PubMed Central PMC4434731.
  22. Novoa, EM, Vargas-Rodriguez, O, Lange, S, Goto, Y, Suga, H, Musier-Forsyth, K et al.. Ancestral AlaX editing enzymes for control of genetic code fidelity are not tRNA-specific. J. Biol. Chem. 2015;290 (16):10495-503. doi: 10.1074/jbc.M115.640060. PubMed PMID:25724653 PubMed Central PMC4400357.
  23. Rye-McCurdy, T, Rouzina, I, Musier-Forsyth, K. Fluorescence anisotropy-based salt-titration approach to characterize protein-nucleic acid interactions. Methods Mol. Biol. 2015;1259 :385-402. doi: 10.1007/978-1-4939-2214-7_23. PubMed PMID:25579598 .
  24. Berkhout, B, Mouland, AJ, Musier-Forsyth, K. Retroviral nucleocapsid protein and assembly. Foreword. Virus Res. 2014;193 :1. doi: 10.1016/j.virusres.2014.10.018. PubMed PMID:25440780 .
  25. Vargas-Rodriguez, O, Musier-Forsyth, K. Structural biology: wobble puts RNA on target. Nature. 2014;510 (7506):480-1. doi: 10.1038/nature13502. PubMed PMID:24919145 .
  26. Wu, H, Wang, W, Naiyer, N, Fichtenbaum, E, Qualley, DF, McCauley, MJ et al.. Single aromatic residue location alters nucleic acid binding and chaperone function of FIV nucleocapsid protein. Virus Res. 2014;193 :39-51. doi: 10.1016/j.virusres.2014.06.002. PubMed PMID:24915282 PubMed Central PMC4252577.
  27. Wang, W, Naiyer, N, Mitra, M, Li, J, Williams, MC, Rouzina, I et al.. Distinct nucleic acid interaction properties of HIV-1 nucleocapsid protein precursor NCp15 explain reduced viral infectivity. Nucleic Acids Res. 2014;42 (11):7145-59. doi: 10.1093/nar/gku335. PubMed PMID:24813443 PubMed Central PMC4066767.
  28. Alemán, EA, de Silva, C, Patrick, EM, Musier-Forsyth, K, Rueda, D. Single-Molecule Fluorescence Using Nucleotide Analogs: A Proof-of-Principle. J Phys Chem Lett. 2014;5 (5):777-781. doi: 10.1021/jz4025832. PubMed PMID:24803990 PubMed Central PMC3985717.
  29. Rye-McCurdy, TD, Nadaraia-Hoke, S, Gudleski-O'Regan, N, Flanagan, JM, Parent, LJ, Musier-Forsyth, K et al.. Mechanistic differences between nucleic acid chaperone activities of the Gag proteins of Rous sarcoma virus and human immunodeficiency virus type 1 are attributed to the MA domain. J. Virol. 2014;88 (14):7852-61. doi: 10.1128/JVI.00736-14. PubMed PMID:24789780 PubMed Central PMC4097784.
  30. Qu, J, Kang, SG, Wang, W, Musier-Forsyth, K, Jang, JC. The Arabidopsis thaliana tandem zinc finger 1 (AtTZF1) protein in RNA binding and decay. Plant J. 2014;78 (3):452-67. doi: 10.1111/tpj.12485. PubMed PMID:24635033 PubMed Central PMC4026020.
  31. Jones, CP, Cantara, WA, Olson, ED, Musier-Forsyth, K. Small-angle X-ray scattering-derived structure of the HIV-1 5' UTR reveals 3D tRNA mimicry. Proc. Natl. Acad. Sci. U.S.A. 2014;111 (9):3395-400. doi: 10.1073/pnas.1319658111. PubMed PMID:24550473 PubMed Central PMC3948283.
  32. Bartholow, TG, Sanford, BL, Cao, B, Schmit, HL, Johnson, JM, Meitzner, J et al.. Strictly conserved lysine of prolyl-tRNA Synthetase editing domain facilitates binding and positioning of misacylated tRNA(Pro.). Biochemistry. 2014;53 (6):1059-68. doi: 10.1021/bi401279r. PubMed PMID:24450765 PubMed Central PMC3986007.
  33. Das, M, Vargas-Rodriguez, O, Goto, Y, Suga, H, Musier-Forsyth, K. Distinct tRNA recognition strategies used by a homologous family of editing domains prevent mistranslation. Nucleic Acids Res. 2014;42 (6):3943-53. doi: 10.1093/nar/gkt1332. PubMed PMID:24371276 PubMed Central PMC3973320.
  34. Chaurasiya, KR, McCauley, MJ, Wang, W, Qualley, DF, Wu, T, Kitamura, S et al.. Oligomerization transforms human APOBEC3G from an efficient enzyme to a slowly dissociating nucleic acid-binding protein. Nat Chem. 2014;6 (1):28-33. doi: 10.1038/nchem.1795. PubMed PMID:24345943 PubMed Central PMC3950479.
  35. Mathias, J, Okyere, R, Lomidze, L, Gvarjaladze, D, Musier-Forsyth, K, Kankia, B et al.. Thermal stability of quadruplex primers for highly versatile isothermal DNA amplification. Biophys. Chem. 2014;185 :14-8. doi: 10.1016/j.bpc.2013.10.008. PubMed PMID:24317195 .
  36. Wu, H, Mitra, M, Naufer, MN, McCauley, MJ, Gorelick, RJ, Rouzina, I et al.. Differential contribution of basic residues to HIV-1 nucleocapsid protein's nucleic acid chaperone function and retroviral replication. Nucleic Acids Res. 2014;42 (4):2525-37. doi: 10.1093/nar/gkt1227. PubMed PMID:24293648 PubMed Central PMC3936775.
  37. Sun, M, Grigsby, IF, Gorelick, RJ, Mansky, LM, Musier-Forsyth, K. Retrovirus-specific differences in matrix and nucleocapsid protein-nucleic acid interactions: implications for genomic RNA packaging. J. Virol. 2014;88 (2):1271-80. doi: 10.1128/JVI.02151-13. PubMed PMID:24227839 PubMed Central PMC3911680.
  38. Mitra, M, Wang, W, Vo, MN, Rouzina, I, Barany, G, Musier-Forsyth, K et al.. The N-terminal zinc finger and flanking basic domains represent the minimal region of the human immunodeficiency virus type-1 nucleocapsid protein for targeting chaperone function. Biochemistry. 2013;52 (46):8226-36. doi: 10.1021/bi401250a. PubMed PMID:24144434 PubMed Central PMC3875364.
  39. Webb, JA, Jones, CP, Parent, LJ, Rouzina, I, Musier-Forsyth, K. Distinct binding interactions of HIV-1 Gag to Psi and non-Psi RNAs: implications for viral genomic RNA packaging. RNA. 2013;19 (8):1078-88. doi: 10.1261/rna.038869.113. PubMed PMID:23798665 PubMed Central PMC3708528.
  40. Johnson, JM, Sanford, BL, Strom, AM, Tadayon, SN, Lehman, BP, Zirbes, AM et al.. Multiple pathways promote dynamical coupling between catalytic domains in Escherichia coli prolyl-tRNA synthetase. Biochemistry. 2013;52 (25):4399-412. doi: 10.1021/bi400079h. PubMed PMID:23731272 PubMed Central PMC3749879.
  41. Vargas-Rodriguez, O, Musier-Forsyth, K. Exclusive use of trans-editing domains prevents proline mistranslation. J. Biol. Chem. 2013;288 (20):14391-9. doi: 10.1074/jbc.M113.467795. PubMed PMID:23564458 PubMed Central PMC3656294.
  42. Jones, CP, Saadatmand, J, Kleiman, L, Musier-Forsyth, K. Molecular mimicry of human tRNALys anti-codon domain by HIV-1 RNA genome facilitates tRNA primer annealing. RNA. 2013;19 (2):219-29. doi: 10.1261/rna.036681.112. PubMed PMID:23264568 PubMed Central PMC3543088.
  43. Taylor, A, Joseph, A, Okyere, R, Gogichaishvili, S, Musier-Forsyth, K, Kankia, B et al.. Isothermal quadruplex priming amplification for DNA-based diagnostics. Biophys. Chem. 2013;171 :1-8. doi: 10.1016/j.bpc.2012.11.001. PubMed PMID:23232099 .
  44. Kumar, S, Das, M, Hadad, CM, Musier-Forsyth, K. Aminoacyl-tRNA substrate and enzyme backbone atoms contribute to translational quality control by YbaK. J Phys Chem B. 2013;117 (16):4521-7. doi: 10.1021/jp308628y. PubMed PMID:23185990 PubMed Central PMC3601562.
  45. Dewan, V, Wei, M, Kleiman, L, Musier-Forsyth, K. Dual role for motif 1 residues of human lysyl-tRNA synthetase in dimerization and packaging into HIV-1. J. Biol. Chem. 2012;287 (50):41955-62. doi: 10.1074/jbc.M112.421842. PubMed PMID:23095741 PubMed Central PMC3516742.
  46. Johnson, J, Okyere, R, Joseph, A, Musier-Forsyth, K, Kankia, B. Quadruplex formation as a molecular switch to turn on intrinsically fluorescent nucleotide analogs. Nucleic Acids Res. 2013;41 (1):220-8. doi: 10.1093/nar/gks975. PubMed PMID:23093597 PubMed Central PMC3592437.
  47. Wu, H, Mitra, M, McCauley, MJ, Thomas, JA, Rouzina, I, Musier-Forsyth, K et al.. Aromatic residue mutations reveal direct correlation between HIV-1 nucleocapsid protein's nucleic acid chaperone activity and retroviral replication. Virus Res. 2013;171 (2):263-77. doi: 10.1016/j.virusres.2012.07.008. PubMed PMID:22814429 PubMed Central PMC3745225.
  48. Wang, H, Musier-Forsyth, K, Falk, C, Barbara, PF. Single-molecule spectroscopic study of dynamic nanoscale DNA bending behavior of HIV-1 nucleocapsid protein. J Phys Chem B. 2013;117 (16):4183-96. doi: 10.1021/jp3018259. PubMed PMID:22591315 PubMed Central PMC3491087.
  49. Kumar, S, Das, M, Hadad, CM, Musier-Forsyth, K. Substrate and enzyme functional groups contribute to translational quality control by bacterial prolyl-tRNA synthetase. J Phys Chem B. 2012;116 (23):6991-9. doi: 10.1021/jp300845h. PubMed PMID:22458656 PubMed Central PMC3376218.
  50. Sanford, B, Cao, B, Johnson, JM, Zimmerman, K, Strom, AM, Mueller, RM et al.. Role of coupled dynamics in the catalytic activity of prokaryotic-like prolyl-tRNA synthetases. Biochemistry. 2012;51 (10):2146-56. doi: 10.1021/bi300097g. PubMed PMID:22356126 PubMed Central PMC3337710.
  51. Dewan, V, Liu, T, Chen, KM, Qian, Z, Xiao, Y, Kleiman, L et al.. Cyclic peptide inhibitors of HIV-1 capsid-human lysyl-tRNA synthetase interaction. ACS Chem. Biol. 2012;7 (4):761-9. doi: 10.1021/cb200450w. PubMed PMID:22276994 PubMed Central PMC3330833.
  52. Kumar, S, Das, M, Hadad, CM, Musier-Forsyth, K. Substrate specificity of bacterial prolyl-tRNA synthetase editing domain is controlled by a tunable hydrophobic pocket. J. Biol. Chem. 2012;287 (5):3175-84. doi: 10.1074/jbc.M111.313619. PubMed PMID:22128149 PubMed Central PMC3270972.
  53. Kessl, JJ, Li, M, Ignatov, M, Shkriabai, N, Eidahl, JO, Feng, L et al.. FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75. Nucleic Acids Res. 2011;39 (20):9009-22. doi: 10.1093/nar/gkr581. PubMed PMID:21771857 PubMed Central PMC3203615.
  54. So, BR, An, S, Kumar, S, Das, M, Turner, DA, Hadad, CM et al.. Substrate-mediated fidelity mechanism ensures accurate decoding of proline codons. J. Biol. Chem. 2011;286 (36):31810-20. doi: 10.1074/jbc.M111.232611. PubMed PMID:21768119 PubMed Central PMC3173103.
  55. Rein, A, Datta, SA, Jones, CP, Musier-Forsyth, K. Diverse interactions of retroviral Gag proteins with RNAs. Trends Biochem. Sci. 2011;36 (7):373-80. doi: 10.1016/j.tibs.2011.04.001. PubMed PMID:21550256 PubMed Central PMC3130074.
  56. Kelley, S, Boroda, S, Musier-Forsyth, K, Kankia, BI. HIV-integrase aptamer folds into a parallel quadruplex: a thermodynamic study. Biophys. Chem. 2011;155 (2-3):82-8. doi: 10.1016/j.bpc.2011.03.004. PubMed PMID:21435774 .
  57. Musier-Forsyth, K. RNA remodeling by chaperones and helicases. RNA Biol. ;7 (6):632-3. . PubMed PMID:21173577 .
  58. Levin, JG, Mitra, M, Mascarenhas, A, Musier-Forsyth, K. Role of HIV-1 nucleocapsid protein in HIV-1 reverse transcription. RNA Biol. ;7 (6):754-74. . PubMed PMID:21160280 PubMed Central PMC3073334.
  59. Jones, CP, Datta, SA, Rein, A, Rouzina, I, Musier-Forsyth, K. Matrix domain modulates HIV-1 Gag's nucleic acid chaperone activity via inositol phosphate binding. J. Virol. 2011;85 (4):1594-603. doi: 10.1128/JVI.01809-10. PubMed PMID:21123373 PubMed Central PMC3028911.
  60. Ranji, A, Shkriabai, N, Kvaratskhelia, M, Musier-Forsyth, K, Boris-Lawrie, K. Features of double-stranded RNA-binding domains of RNA helicase A are necessary for selective recognition and translation of complex mRNAs. J. Biol. Chem. 2011;286 (7):5328-37. doi: 10.1074/jbc.M110.176339. PubMed PMID:21123178 PubMed Central PMC3037645.
  61. Wang, H, Ma, X, Yeh, YS, Zhu, Y, Daugherty, MD, Frankel, AD et al.. Comparative analysis of RNA/protein dynamics for the arginine-rich-binding motif and zinc-finger-binding motif proteins encoded by HIV-1. Biophys. J. 2010;99 (10):3454-62. doi: 10.1016/j.bpj.2010.09.051. PubMed PMID:21081095 PubMed Central PMC2980704.
  62. Kleiman, L, Jones, CP, Musier-Forsyth, K. Formation of the tRNALys packaging complex in HIV-1. FEBS Lett. 2010;584 (2):359-65. doi: 10.1016/j.febslet.2009.11.038. PubMed PMID:19914238 PubMed Central PMC2820394.
  63. Qualley, DF, Stewart-Maynard, KM, Wang, F, Mitra, M, Gorelick, RJ, Rouzina, I et al.. C-terminal domain modulates the nucleic acid chaperone activity of human T-cell leukemia virus type 1 nucleocapsid protein via an electrostatic mechanism. J. Biol. Chem. 2010;285 (1):295-307. doi: 10.1074/jbc.M109.051334. PubMed PMID:19887455 PubMed Central PMC2804176.
  64. Mascarenhas, AP, Musier-Forsyth, K. The capsid protein of human immunodeficiency virus: interactions of HIV-1 capsid with host protein factors. FEBS J. 2009;276 (21):6118-27. doi: 10.1111/j.1742-4658.2009.07315.x. PubMed PMID:19825046 .
  65. Ling, J, So, BR, Yadavalli, SS, Roy, H, Shoji, S, Fredrick, K et al.. Resampling and editing of mischarged tRNA prior to translation elongation. Mol. Cell. 2009;33 (5):654-60. doi: 10.1016/j.molcel.2009.01.031. PubMed PMID:19285947 PubMed Central PMC2944653.
  66. Chen, Y, Wu, B, Musier-Forsyth, K, Mansky, LM, Mueller, JD. Fluorescence fluctuation spectroscopy on viral-like particles reveals variable gag stoichiometry. Biophys. J. 2009;96 (5):1961-9. doi: 10.1016/j.bpj.2008.10.067. PubMed PMID:19254556 PubMed Central PMC2717261.
  67. Post, K, Kankia, B, Gopalakrishnan, S, Yang, V, Cramer, E, Saladores, P et al.. Fidelity of plus-strand priming requires the nucleic acid chaperone activity of HIV-1 nucleocapsid protein. Nucleic Acids Res. 2009;37 (6):1755-66. doi: 10.1093/nar/gkn1045. PubMed PMID:19158189 PubMed Central PMC2665208.
  68. Vo, MN, Barany, G, Rouzina, I, Musier-Forsyth, K. Effect of Mg(2+) and Na(+) on the nucleic acid chaperone activity of HIV-1 nucleocapsid protein: implications for reverse transcription. J. Mol. Biol. 2009;386 (3):773-88. doi: 10.1016/j.jmb.2008.12.073. PubMed PMID:19154740 PubMed Central PMC2642912.
  69. Vo, MN, Barany, G, Rouzina, I, Musier-Forsyth, K. HIV-1 nucleocapsid protein switches the pathway of transactivation response element RNA/DNA annealing from loop-loop "kissing" to "zipper". J. Mol. Biol. 2009;386 (3):789-801. doi: 10.1016/j.jmb.2008.12.070. PubMed PMID:19154737 PubMed Central PMC2646174.
  70. Yadavalli, SS, Musier-Forsyth, K, Ibba, M. The return of pretransfer editing in protein synthesis. Proc. Natl. Acad. Sci. U.S.A. 2008;105 (49):19031-2. doi: 10.1073/pnas.0810781106. PubMed PMID:19057010 PubMed Central PMC2614708.
  71. Wei, M, Yang, Y, Niu, M, Desfosse, L, Kennedy, R, Musier-Forsyth, K et al.. Inability of human immunodeficiency virus type 1 produced in murine cells to selectively incorporate primer formula. J. Virol. 2008;82 (24):12049-59. doi: 10.1128/JVI.01744-08. PubMed PMID:18842718 PubMed Central PMC2593337.
  72. Stewart-Maynard, KM, Cruceanu, M, Wang, F, Vo, MN, Gorelick, RJ, Williams, MC et al.. Retroviral nucleocapsid proteins display nonequivalent levels of nucleic acid chaperone activity. J. Virol. 2008;82 (20):10129-42. doi: 10.1128/JVI.01169-08. PubMed PMID:18684831 PubMed Central PMC2566285.
  73. Burke, B, An, S, Musier-Forsyth, K. Functional guanine-arginine interaction between tRNAPro and prolyl-tRNA synthetase that couples binding and catalysis. Biochim. Biophys. Acta. 2008;1784 (9):1222-5. doi: 10.1016/j.bbapap.2008.04.027. PubMed PMID:18513497 PubMed Central PMC2559941.
  74. An, S, Barany, G, Musier-Forsyth, K. Evolution of acceptor stem tRNA recognition by class II prolyl-tRNA synthetase. Nucleic Acids Res. 2008;36 (8):2514-21. doi: 10.1093/nar/gkn063. PubMed PMID:18310681 PubMed Central PMC2377447.
  75. Guo, M, Ignatov, M, Musier-Forsyth, K, Schimmel, P, Yang, XL. Crystal structure of tetrameric form of human lysyl-tRNA synthetase: Implications for multisynthetase complex formation. Proc. Natl. Acad. Sci. U.S.A. 2008;105 (7):2331-6. doi: 10.1073/pnas.0712072105. PubMed PMID:18272479 PubMed Central PMC2268136.
  76. Splan, KE, Musier-Forsyth, K, Boniecki, MT, Martinis, SA. In vitro assays for the determination of aminoacyl-tRNA synthetase editing activity. Methods. 2008;44 (2):119-28. doi: 10.1016/j.ymeth.2007.10.009. PubMed PMID:18241793 PubMed Central PMC2270698.
  77. Splan, KE, Ignatov, ME, Musier-Forsyth, K. Transfer RNA modulates the editing mechanism used by class II prolyl-tRNA synthetase. J. Biol. Chem. 2008;283 (11):7128-34. doi: 10.1074/jbc.M709902200. PubMed PMID:18180290 .
  78. Iwatani, Y, Chan, DS, Wang, F, Maynard, KS, Sugiura, W, Gronenborn, AM et al.. Deaminase-independent inhibition of HIV-1 reverse transcription by APOBEC3G. Nucleic Acids Res. 2007;35 (21):7096-108. doi: 10.1093/nar/gkm750. PubMed PMID:17942420 PubMed Central PMC2175344.
  79. Kovaleski, BJ, Kennedy, R, Khorchid, A, Kleiman, L, Matsuo, H, Musier-Forsyth, K et al.. Critical role of helix 4 of HIV-1 capsid C-terminal domain in interactions with human lysyl-tRNA synthetase. J. Biol. Chem. 2007;282 (44):32274-9. doi: 10.1074/jbc.M706256200. PubMed PMID:17724017 .
  80. Landes, CF, Zeng, Y, Liu, HW, Musier-Forsyth, K, Barbara, PF. Single-molecule study of the inhibition of HIV-1 transactivation response region DNA/DNA annealing by argininamide. J. Am. Chem. Soc. 2007;129 (33):10181-8. doi: 10.1021/ja071491r. PubMed PMID:17658799 .
  81. Zeng, Y, Liu, HW, Landes, CF, Kim, YJ, Ma, X, Zhu, Y et al.. Probing nucleation, reverse annealing, and chaperone function along the reaction path of HIV-1 single-strand transfer. Proc. Natl. Acad. Sci. U.S.A. 2007;104 (31):12651-6. doi: 10.1073/pnas.0700350104. PubMed PMID:17578926 PubMed Central PMC1937521.
  82. Liu, HW, Zeng, Y, Landes, CF, Kim, YJ, Zhu, Y, Ma, X et al.. Insights on the role of nucleic acid/protein interactions in chaperoned nucleic acid rearrangements of HIV-1 reverse transcription. Proc. Natl. Acad. Sci. U.S.A. 2007;104 (13):5261-7. doi: 10.1073/pnas.0700166104. PubMed PMID:17372205 PubMed Central PMC1828707.
  83. SternJohn, J, Hati, S, Siliciano, PG, Musier-Forsyth, K. Restoring species-specific posttransfer editing activity to a synthetase with a defunct editing domain. Proc. Natl. Acad. Sci. U.S.A. 2007;104 (7):2127-32. doi: 10.1073/pnas.0611110104. PubMed PMID:17283340 PubMed Central PMC1892958.
  84. Kankia, BI, Musier-Forsyth, K. The HIV-1 central DNA flap region contains a "flapping" third strand. Biophys. Chem. 2007;127 (1-2):64-8. doi: 10.1016/j.bpc.2006.12.005. PubMed PMID:17215070 .
  85. Cruceanu, M, Gorelick, RJ, Musier-Forsyth, K, Rouzina, I, Williams, MC. Rapid kinetics of protein-nucleic acid interaction is a major component of HIV-1 nucleocapsid protein's nucleic acid chaperone function. J. Mol. Biol. 2006;363 (5):867-77. doi: 10.1016/j.jmb.2006.08.070. PubMed PMID:16997322 .
  86. Vo, MN, Barany, G, Rouzina, I, Musier-Forsyth, K. Mechanistic studies of mini-TAR RNA/DNA annealing in the absence and presence of HIV-1 nucleocapsid protein. J. Mol. Biol. 2006;363 (1):244-61. doi: 10.1016/j.jmb.2006.08.039. PubMed PMID:16962137 .
  87. Hati, S, Ziervogel, B, Sternjohn, J, Wong, FC, Nagan, MC, Rosen, AE et al.. Pre-transfer editing by class II prolyl-tRNA synthetase: role of aminoacylation active site in "selective release" of noncognate amino acids. J. Biol. Chem. 2006;281 (38):27862-72. doi: 10.1074/jbc.M605856200. PubMed PMID:16864571 .
  88. Rosen, AE, Brooks, BS, Guth, E, Francklyn, CS, Musier-Forsyth, K. Evolutionary conservation of a functionally important backbone phosphate group critical for aminoacylation of histidine tRNAs. RNA. 2006;12 (7):1315-22. doi: 10.1261/rna.78606. PubMed PMID:16741232 PubMed Central PMC1484442.
  89. Kovaleski, BJ, Kennedy, R, Hong, MK, Datta, SA, Kleiman, L, Rein, A et al.. In vitro characterization of the interaction between HIV-1 Gag and human lysyl-tRNA synthetase. J. Biol. Chem. 2006;281 (28):19449-56. doi: 10.1074/jbc.M601189200. PubMed PMID:16702215 .
  90. Cosa, G, Zeng, Y, Liu, HW, Landes, CF, Makarov, DE, Musier-Forsyth, K et al.. Evidence for non-two-state kinetics in the nucleocapsid protein chaperoned opening of DNA hairpins. J Phys Chem B. 2006;110 (5):2419-26. doi: 10.1021/jp054189i. PubMed PMID:16471833 .
  91. Pinto, YY, Le, JD, Seeman, NC, Musier-Forsyth, K, Taton, TA, Kiehl, RA et al.. Sequence-encoded self-assembly of multiple-nanocomponent arrays by 2D DNA scaffolding. Nano Lett. 2005;5 (12):2399-402. doi: 10.1021/nl0515495. PubMed PMID:16351185 .
  92. Levin, JG, Guo, J, Rouzina, I, Musier-Forsyth, K. Nucleic acid chaperone activity of HIV-1 nucleocapsid protein: critical role in reverse transcription and molecular mechanism. Prog. Nucleic Acid Res. Mol. Biol. 2005;80 :217-86. doi: 10.1016/S0079-6603(05)80006-6. PubMed PMID:16164976 .
  93. Liu, HW, Cosa, G, Landes, CF, Zeng, Y, Kovaleski, BJ, Mullen, DG et al.. Single-molecule FRET studies of important intermediates in the nucleocapsid-protein-chaperoned minus-strand transfer step in HIV-1 reverse transcription. Biophys. J. 2005;89 (5):3470-9. doi: 10.1529/biophysj.105.065326. PubMed PMID:16100256 PubMed Central PMC1366842.
  94. An, S, Musier-Forsyth, K. Cys-tRNA(Pro) editing by Haemophilus influenzae YbaK via a novel synthetase.YbaK.tRNA ternary complex. J. Biol. Chem. 2005;280 (41):34465-72. doi: 10.1074/jbc.M507550200. PubMed PMID:16087664 .
  95. Kankia, BI, Barany, G, Musier-Forsyth, K. Unfolding of DNA quadruplexes induced by HIV-1 nucleocapsid protein. Nucleic Acids Res. 2005;33 (14):4395-403. doi: 10.1093/nar/gki741. PubMed PMID:16077025 PubMed Central PMC1182697.
  96. Cosa, G, Harbron, EJ, Zeng, Y, Liu, HW, O'Connor, DB, Eta-Hosokawa, C et al.. Secondary structure and secondary structure dynamics of DNA hairpins complexed with HIV-1 NC protein. Biophys. J. 2004;87 (4):2759-67. doi: 10.1529/biophysj.104.043083. PubMed PMID:15454467 PubMed Central PMC1304694.
  97. An, S, Musier-Forsyth, K. Trans-editing of Cys-tRNAPro by Haemophilus influenzae YbaK protein. J. Biol. Chem. 2004;279 (41):42359-62. doi: 10.1074/jbc.C400304200. PubMed PMID:15322138 .
  98. Gunasekera, N, Lee, SW, Kim, S, Musier-Forsyth, K, Arriaga, E. Nuclear localization of aminoacyl-tRNA synthetases using single-cell capillary electrophoresis laser-induced fluorescence analysis. Anal. Chem. 2004;76 (16):4741-6. doi: 10.1021/ac049567e. PubMed PMID:15307785 .
  99. Gunasekera, N, Xiong, G, Musier-Forsyth, K, Arriaga, E. A capillary electrophoretic method for monitoring the presence of alpha-tubulin in nuclear preparations. Anal. Biochem. 2004;330 (1):1-9. doi: 10.1016/j.ab.2004.03.059. PubMed PMID:15183755 .
  100. Hargittai, MR, Gorelick, RJ, Rouzina, I, Musier-Forsyth, K. Mechanistic insights into the kinetics of HIV-1 nucleocapsid protein-facilitated tRNA annealing to the primer binding site. J. Mol. Biol. 2004;337 (4):951-68. doi: 10.1016/j.jmb.2004.01.054. PubMed PMID:15033363 .
  101. Gunasekera, N, Olson, KJ, Musier-Forsyth, K, Arriaga, EA. Capillary electrophoretic separation of nuclei released from single cells. Anal. Chem. 2004;76 (3):655-62. doi: 10.1021/ac034916a. PubMed PMID:14750860 .
  102. Connolly, SA, Rosen, AE, Musier-Forsyth, K, Francklyn, CS. G-1:C73 recognition by an arginine cluster in the active site of Escherichia coli histidyl-tRNA synthetase. Biochemistry. 2004;43 (4):962-9. doi: 10.1021/bi035708f. PubMed PMID:14744140 .
  103. Rosen, AE, Musier-Forsyth, K. Recognition of G-1:C73 atomic groups by Escherichia coli histidyl-tRNA synthetase. J. Am. Chem. Soc. 2004;126 (1):64-5. doi: 10.1021/ja0381609. PubMed PMID:14709061 .
Search PubMed

Recent Posts


  • Congratulations to Dr. Wei Wang who successfully defended his dissertation on Nov. 1, 2013!
  • Congratulations to Dr. Oscar Vargas-Rodriguez who successfully defended his dissertation on April 4, 2014!
  • Congratulations to Dr. Brianne Sanford who successfully defended her dissertation on April 7, 2014!
  1. New Publications Comments Off on New Publications