I am interested in the relationship between macromolecular structure and function, and have found a way to appease that interest by studying Cre-loxP recombination via a variety of biophysical characterization techniques. My current goal is to continue PRE experiments with full-length Cre to gain insights into the structure and dynamics of intermediates along the recombination pathway.
I am interested in using physical biochemistry techniques such as NMR to study protein structure and dynamics. I am currently studying Cre Recombinase and how dynamics and structural elements facilitate target sequence identity and DNA scanning against nonspecific sites.
I am interested in studying protein thermodynamics using Native Mass spectrometry. I am co-advised by Vicki Wysocki. I am currently working with studying binding in Loz1 and TRAP.
I am interested in utilizing physical biochemistry techniques to study the relationship between macromolecular structure and function. Currently my goal is to investigate the apo structure of Cre recombinase, particularly looking at variations in active site orientation between apo- and DNA-bound Cre.
I use biophysical methods such as NMR and ITC to study protein structure and dynamics. I am currently studying how certain structural elements facilitate the binding specificity and recombination efficiency of the Cre-loxP system. I also work full-time as a staff TA for the organic chemistry instructional labs.
Caroline Hervey
I am an undergraduate biochemistry major, minoring in Epidemiology. I am currently studying how the binding specificity and recombination efficacy of the Cre-loxP system is facilitated by structural elements.
Madelyn Highfield
I am an undergraduate biochemistry major minoring in pharmaceutical sciences and music. I am studying heterogeneity in the Cre-loxP recombination system.
