Dr. Venkat Gopalan


 

Melvin S. Newman Professor of Chemistry and Biochemistry
Department of Chemistry and Biochemistry
Center for RNA Biology
The Ohio State University
484 West 12th Avenue
774 Biological Sciences Building
Columbus, OH 43210
 

Phone: (614) 292-1332
Fax: (614) 292-6773
Email: gopalan.5@osu.edu
 

Education and Training

1995 Visiting Scientist
MRC Laboratory of Molecular Biology, Cambridge, UK
Mentor: Sir Aaron Klug
1992 – 1997 Postdoctoral Research Associate
Yale University, New Haven, CT
Mentor: Dr. Sidney Altman
1991 Ph.D. in Biochemistry
University of New Mexico, Albuquerque, NM
Advisor: Dr. Robert H. Glew
1986 B.S. in Chemistry
University of Madras, Madras, India

 

Professional Positions

2010 to date Professor
Department of Chemistry and Biochemistry (renamed after a merger in July 2012)
The Ohio State University, Columbus, OH
2003 – 2010 Associate Professor
Department of Biochemistry
The Ohio State University, Columbus, OH
1998 – 2003 Assistant Professor
Department of Biochemistry
The Ohio State University, Columbus, OH
1995 Visiting Scientist
MRC Laboratory of Molecular Biology, Cambridge, UK
Mentor: Sir Aaron Klug, Professor and Director
1992 – 1997 Postdoctoral Research Associate
Department of Biology
Yale University, New Haven, CT
Mentor: Sidney Altman, Sterling Professor of Biology and Chemistry
1990 – 1991 Graduate Student Researcher
Department of Biochemistry
University of New Mexico, Albuquerque, NM
Advisor: Robert H. Glew, Professor and Chairperson
1986 – 1990 Graduate Student Researcher
Department of Microbiology, Biochemistry, and Molecular Biology
University of Pittsburgh School of Medicine, Pittsburgh, PA
Advisor: Robert H. Glew, Professor

 

Honors and Awards

2018 OSU College of Arts and Sciences Diversity Enhancement Faculty Award (with Drs. Susan Cole, Department of Molecular Genetics; Jane Jackman, Department of Chemistry and Biochemistry; and Amanda Simcox, Department of Molecular Genetics)
2017 – 2022 Melvin S. Newman Professor of Chemistry and Biochemistry
2010 The Ohio State University Alumni Distinguished Teaching Award
2010 Bringing the World into the Classroom: American Council of Education Award to Recognize Innovative Use of Technology to Promote Internationalization (Finalist)
2009 The Ohio State University Rosalene Sedgwick Faculty Service Award
2008 The Ohio State University Harlan Hatcher Award for Academic Excellence
2007 The Ohio State University Department of Biochemistry Award for Excellence
2005 The Ohio State University College of Biological Sciences Dean’s Award for Classroom Teaching
2004 The Ohio State University Colleges of Arts and Sciences Student Council Outstanding Teacher Award (Finalist)
2003 The Ohio State University College of Biological Sciences Dean’s Award for Undergraduate Research Mentoring
2003 – 2008 National Science Foundation CAREER Award
1995 – 1996 Anna Fuller Cancer Research Fund Postdoctoral Fellowship
1993 – 1995 Donaghue Medical Research Foundation Postdoctoral Fellowship

 

Publications (prior to independent position at OSU)

*Corresponding author(s)
Gopalan V, Golbik R, Schreiber G, Fersht AR, and Altman S*. (1997) Fluorescence properties of a tryptophan residue in an aromatic core of the protein subunit of ribonuclease P from Escherichia coli. J. Mol. Biol.267: 765-769.
Gopalan V, Baxevanis AD, Landsman D, and Altman S*. (1997) Analysis of the functional role of conserved residues in the protein subunit of ribonuclease P from Escherichia coliJ. Mol. Biol.267: 818-829.
Gopalan V, Talbot SJ, and Altman S*. (1994) RNA-protein interactions in RNase P. In K. Nagai and I. Mattaj (Eds.), RNA-Protein Interactions – Frontiers in Molecular Biology (pp. 103-126). Oxford, UK: Oxford University Press.
Glew RH*, Gopalan V, Forsyth GW, and Vander Jagt DJ. (1993) The mammalian cytosolic broad-specificity ß-glucosidase. In A. Esen (Ed.), ß-glucosidases: Biochemistry and Molecular Biology (pp. 83-112). Washington, D.C.: American Chemical Society.
Gopalan V, Pastuszyn A, Galey WR Jr, and Glew RH*. (1992) Exolytic hydrolysis of toxic plant glucosides by guinea pig liver cytosolic ß-glucosidase. J. Biol. Chem.267: 14027-14032.
Gopalan V, Vander Jagt DJ, Libell DP, and Glew RH*. (1992) Transglucosylation as a probe of the mechanism of action of mammalian cytosolic ß-glucosidase. J. Biol. Chem.267: 9629-9638.
Lai LB, Gopalan V, and Glew RH*. (1992) Continuous spectrophotometric assays for ß-glucosidases acting on the plant glucosides L-picein and prunasin. Anal. Biochem.200: 365-369.
Glew, RH*, Gopalan V, Hubbell CA, Devraj RV, Lawson RA, Diven WF, and Mannock DA. (1991) 2,3-Di-O-tetradecyl-1-O-(ß-D-glucopyranosyl)-sn-glycerol is a substrate for human glucocerebrosidase. Biochem. J.274: 557-563.
Glew RH*, Gopalan V, Hubbell CA, Beutler E, Geil JD, and Lee RE. (1991) A case of nonneurologic Gaucher’s disease that biochemically resembles the neurologic types. J. Neuropathol. Exp. Neurol.50: 108-117.
Butcher BA, Gopalan V, Lee RE, Richards TC, Waggoner AS, and Glew RH*. (1989) Use of 4-heptylumbelliferyl-ß-D-glucoside to identify Gaucher’s disease heterozygotes. Clin. Chim. Acta184: 235-242.
Gopalan V, Glew RH*, Libell DP, and DePetro JJ. (1989) The dual effects of alcohols on the kinetic properties of guinea pig liver cytosolic ß-glucosidase. J. Biol. Chem.264: 15418-15422.
Gopalan V, Daniels LB, Glew RH*, and Claeyssens M. (1989) Kinetic analysis of the interaction of alkyl glycosides with two human ß-glucosidases. Biochem. J.262: 541-548.