David Nagib

David A Nagib

Boston College
B.S. with Honors, 2006 
Advisor: Scott J. Miller

Princeton University
Ph.D. in Chemistry, 2011
Advisor: David W.C. MacMillan

University of California, Berkeley
NIH Postdoctoral Fellow, 2014
Advisor: F. Dean Toste

David grew up near Philadelphia, PA as the eldest of four siblings in an Egyptian family with a strong love for teaching and education. In 2006, he earned a B.S. in Chemistry at Boston College, where he was awarded the university’s Scholar of the College prize for his thesis work with Prof. Scott Miller. During this period, he developed small peptide catalysts that serve as synthetically-controllable enzyme-mimics to desymmetrize meso-diols. In 2011, he earned his Ph.D. with Prof. David MacMillan at Princeton University, developing several new trifluoromethylation reactions by pioneering catalytic strategies for the mild generation of CF3 radicals. During his graduate studies, David developed the first catalytic, enantioselective trifluoromethylation of carbonyls by combining organocatalytic activation with photoredox catalysis. He further developed this radical-based strategy to enable the streamlined synthesis of medicinally-important aryl and heteroaryl organofluorines with numerous applications towards the late-stage C-H functionalization of medicinal agents such as lipitor and ibuprofen. As a Ruth L. Kirschstein NIH Postdoctoral Scholar with Prof. F. Dean Toste at the University of California, Berkeley, David continued developing new C-H activation strategies by harnessing selective, oxidative gold mechanisms and exploring their unique C-C and C-N bond-forming reactivity. In collaboration with Prof. Omar Yaghi, he also explored the catalytic utility of post-synthetically modified MOF (metal-organic framework) materials as size-specific heterogeneous catalyst architectures. In 2014, David joined the faculty of The Ohio State University as an assistant professor in the Department of Chemistry and Biochemistry. His team’s research on radical-mediated C-H and C-O functionalization has been recognized with awards by the ACS, NIH, NSF, and Sloan Foundation. When not working alongside his awesome labmates, David enjoys running along the Scioto River, checking out Columbus‘ vibrant foodie scene, and planning future world travels.

Recent Awards and Honors

2019 Sloan Research Fellow, Alfred P. Sloan Foundation (Sloan)
2019 Emerging Investigator, Chemical Communications (Chem Comm)
2018 Featured Young Investigator, American Chemical Society (ACS Select)
2017 Faculty Early Career Development Award, National Science Foundation (NSF CAREER)
2017 Thieme Chemistry Journals Award (Thieme)
2016 Outstanding Investigator Award, National Institutes of Health (NIH MIRA)
2016 Distinguished Undergraduate Research Mentor Award (Finalist), The Ohio State University (OSU)
2015 Doctoral New Investigator Award, American Chemical Society, Petroleum Research Fund (ACS PRF)
2012 Ruth L. Kirschstein Postdoctoral Fellowship, National Institutes of Health (NIH F32)

In the news …

David Nagib named 2019 Sloan Research Fellow, Spring 2019
Masked aldehyde makes mild radical reaction possible, C&E News, Fall 2018
A new way to create molecules for drug development, Fall 2018
College of Arts and Sciences: Research highlights, Spring 2018
Building Better Medicine, Spring 2017
Honors and recognition: NSF CAREER Award, Spring 2017
Chemist’s New NIH MIRA Grant a Game-Changer for Drug Discovery, Sep 2016