Publications

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Nature ChemistryEnantioselective Radical C–H Amination for the Synthesis of β-Amino Alcohols
Kohki M. Nakafuku †, Zuxiao Zhang †, Ethan A. Wappes †, Leah M. Stateman, Andrew D. Chen, and David A. Nagib
Nature Chem., 2020, 12, 697–704 (open access)
 
Highlighted in OSU News, “Turning alcohol into key ingredients for new medicines” by Laura Arenschield 
Featured on Ohio 24/7 Now, “Alcohol & Amino Acids” by Myles Harris
Behind the Paper in Nature Chemistry Communities
JACSVicinal, Double C–H Functionalization of Alcohols via an Imidate Radical-Polar Crossover Cascade
Allen F. Prusinowski, Raymond K. Twumasi, Ethan A. Wappes, and David A. Nagib
J. Am. Chem. Soc., 2020142, 5429−5438
 
Most Read Article in JACS, Mar/Apr 2020
Highlighted in C&E News, “Adding two functional groups to an aliphatic alcohol in one shot” by Fernando Gomollón-Bel, C&E News, 2020, 98 (12), 7
Highlighted in ChemistryViews, “Double Functionalization of Alcohols” Mar 2020
Radical Cascade Synthesis of Azoles via Tandem Hydrogen Atom Transfer
Andrew D. Chen †, James H. Herbort †, Ethan A. Wappes, Kohki M. Nakafuku, Darsheed N. Mustafa, and David A. Nagib
Chem. Sci., 202011, 2479−2486
 
Highlighted in Synfacts, “Radical Cascade Synthesis of Azoles” Synfacts202016, 429
Chiral Piperidines from Acyclic Amines via Enantioselective, Radical-Mediated δ C–H Cyanation
Zuxiao Zhang, Xin Zhang, and David A. Nagib
Chem, 2019, 5, 3127−3134  (Open Access Pre-Print)
Highlighted in Chem, “Copper Interrupts N-Radical Reactivity and Enables Access to Enantiopure Piperidines” by McMillan and Leonori, Chem, 2019, 5, 3008−2010
Highlighted in OSU News, “A simpler way to make some medicines” by Laura Arenschield
Featured as cover art, Dec 2019 issue of Chem
Development of an Imine Chaperone for Selective C–H Functionalization of Alcohols via Radical Relay
Kohki M. Nakafuku †, Raymond K. Twumasi †, Avassaya Vanitcha †, Ethan A. Wappes, Kayambu Namitharan, Mathieu Bekkaye, and David A. Nagib
J. Org. Chem., 2019, 84, 13065−13072
 
Featured in Special Issue on C-H Bond Functionalization
Most Read Article in J. Org. Chem., Sept/Oct 2019
Top 10 Most Read Article of the Year, JOC 2019
Multi-component Heteroarene Couplings via Polarity-reversed Radical Cascades
Jeremy M. Lear †, J. Quentin Buquoi †, Xin Gu, Kui Pan, Darsheed N. Mustafa, and David A. Nagib
Chem. Commun., 2019, 55, 8820−8823
 
Featured in 2019 Emerging Investigators’ Special Issue (Profile)
Heteroarene Phosphinylalkylation via a Catalytic, Polarity-Reversing Radical Cascade
J. Quentin Buquoi †, Jeremy M. Lear †, Xin Gu, and David A. Nagib
ACS Catal., 2019, 9, 5330−5335
 
Most Read Article in ACS Catalysis, May/Jun 2019
Top 20 Most Read Articles of the year, ACS Catalysis, 2019
Catalytic β C–H amination via an imidate radical relay
Leah M. Stateman, Ethan A. Wappes, Kohki M. Nakafuku, Kara M. Edwards, and David A. Nagib
Chem. Sci., 2019, 10, 2693−2699
 
 Highlighted in Chem. Sci. “Editor’s Choice” Collection, 2019
Site-Selective C–H Functionalization of (Hetero)Arenes via Transient, Non-symmetric Iodanes
Stacy C. Fosu †, Chido M. Hambira †, Andrew D. Chen, James R. Fuchs, and David A. Nagib
Chem, 2019, 5, 417−428 (Open Access)
 
Highlighted in Chem, “More Than Just Acetates: PhI(OAc)2 Enables C–H Halogenation of Arenes” by Wengryniuk, Chem, 2019, 5, 254–262
Highlighted in Chem, “150th Anniversary of the Periodic Table: Breakthrough Research on Halogens”
δ C−H (Hetero)Arylation via Cu-Catalyzed Radical Relay
Zuxiao Zhang, Leah M. Stateman, and David A. Nagib
Chem. Sci., 2019, 10, 1207−1211
 
Highlighted in Synfacts, “Copper-Catalyzed Remote Arylation” Synfacts, 201915, 171
Highlighted in Organic Chemistry Portal, Oct 2019
Highlighted in Chem. Sci., “Most popular 2018-2019 organic chemistry articles”
Ketyl radical reactivity via atom transfer catalysis
Lu Wang, Jeremy M. Lear, Sean M. Rafferty, Stacy C. Fosu and David A. Nagib
Science, 2018, 362, 225−229 (open access)
 
Highlighted in Science, “Easy access to elusive radical reactions” by Blackburn and Roizen, Science, 2018362, 157−158
Highlighted in C&E News, “Masked aldehyde makes mild radical reaction possible” by Tien Nguyen, C&E News, 2018, 96 (42), 7
Highlighted in OSU News, “A new way to create molecules for drug development” by Jeff Grabmeier
Highlighted in OPRD, “Some Items of Interest to Process R&D Chemists and Engineers” Org. Process Res. Dev., 2018, 22, 1687
Highlighted in Synfacts, “Iodine Atom Transfer Catalysis via Ketyl Radicals” Synfacts, 2019, 15, 63
JACSCatalytic Alkene Difunctionalization via Imidate Radicals
Kohki M. Nakafuku †, Stacy C. Fosu †, and David A. Nagib
J. Am. Chem. Soc., 2018, 140, 11202−11205
 
One of the “Most Read” articles in JACS, Aug-Oct 2018.
Highlighted in OPRD, Oct 2018. “Some Items of Interest to Process R&D Chemists and Engineers” Org. Process Res. Dev., 2018, 22, 1335
β C–H di-halogenation via iterative hydrogen atom transfer
Ethan A. Wappes †, Avassaya Vanitcha †, and David A. Nagib
Chem. Sci., 2018, 9, 4500–4504
 
Highlighted in Organic Chemistry Portal, Nov 2018
nature2011Directed β C–H Amination of Alcohols via Radical Relay Chaperones
Ethan A. Wappes †, Kohki M. Nakafuku †, and David A. Nagib
J. Am. Chem. Soc., 2017139, 10204–10207
 
Highlighted in OPRD, Sept 2017. “Some Items of Interest to Process R&D Chemists and Engineers” Org. Process Res. Dev., 2017, 21, 1196
Highlighted in Synform, Nov 2017
Highlighted (twice) in Organic Chemistry Portal, May 2018 and Sept 2018
Highlighted in ACS Select “JACS Young Investigators” virtual issue, Aug 2018
Highlighted in OPRD, Dec 2018. “Green Chemistry Articles of Interest to the Pharmaceutical Industry” Org. Process Res. Dev. 2018, 22, 1699
Triiodide-Mediated δ-Amination of Secondary C-H Bonds
Ethan A. Wappes, Stacy C. Fosu, Trevor C. Chopko, and David A. Nagib
Angew. Chem. Int. Ed., 2016, 55, 9974–9978
 
 
Highlighted in Synform, featured as cover article, Nov 2016
Highlighted in Organic Chemistry Portal, Sept 2017

Reviews

Remote C–H Functionalization via Selective Hydrogen Atom Transfer
Leah M. Stateman, Kohki M. Nakafuku, and David A. Nagib
Synthesis, 2018, 50, 1569–1586
 
An essential guide to selective C-H functionalization by radicals (for experts and beginners alike)

Perspectives & Highlights

Nitrogen gets radical
David A. Nagib
Nature Chem., 2019, 11, 396–398

Radical Conversion of Acids to Alkenes via Dual Catalysis
Allen F. Prusinowski and David A. Nagib
Trends in Chemistry, 2019, 1, 452-453

Catalytic Desymmetrization by C-H Functionalization as a Solution to the Chiral Methyl Problem
David A. Nagib
Angew. Chem. Int. Ed., 2017, 56, 7354–7356

Catalytic, Asymmetric Alkylation via Excited-State Iminium Ions
David A. Nagib
Chem, 2017, 2, 616–618

Pre-OSU

nature2011Seven Post-Synthetic Covalent Reactions in Tandem Leading to Enzyme-Like Complexity within Metal-Organic Framework Crystals
Alejandro M. Fracaroli, Peter Siman, David A. Nagib, Mitsuharu Suzuki, Hiroyasu Furukawa, F. Dean Toste, and Omar M. Yaghi
J. Am. Chem. Soc., 2016138, 8352–8355
 
Highlighted in Nature Nanotechnology, “Enzyme pretenders” by Bryden Le Bailly, Aug 2016.
nature2011Trifluoromethylation of Arenes and Heteroarenes by Means of Photoredox Catalysis
David A. Nagib & David W. C. MacMillan
Nature, 2011480, 224–228
 
Awarded highest ranking of “Exceptional” by the Faculty of 1000
Highlighted by Parsons & Buchwald, Nature, 2011, 480, 184–185
> 900 citations
AngewCover2Photoredox Catalysis: A Mild, Operationally Simple Approach to the Synthesis of α-Trifluoromethyl Carbonyl Compounds
Phong V. Pham, David A. Nagib, David W. C. MacMillan
Angew. Chem. Int. Ed., 2011, 50, 6119–6122
 
 


Selected as a “Hot Paper” by the editors of ACIE
> 350 citations

JACSEnantioselective α-Trifluoromethylation of Aldehydes via Photoredox Organocatalysis
David A. Nagib, Mark E. Scott, David W. C. MacMillan
J. Am. Chem. Soc., 2009131, 10875–10877
 
 

Most downloaded synthetic methods article in JACS for all of 2009
> 850 citations