| Key Publications (Graphic Summary): | |
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 | Chiral pyrrolidines via an enantioselective Hofmann-Löffler-Freytag reaction Pavitra Laohapaisan, Ipshita Roy, and David A. Nagib Chem Catalysis, 2024, DOI: 10.1016/j.checat.2024.101149 (open access) |
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 | Radical Polarity Jacob J. A. Garwood, Andrew D. Chen, and David A. Nagib J. Am. Chem. Soc., 2024, 146, 28034–28059 |
 Top 5 Most Read Articles in JACS for entire year (#1 for Oct) Highlighted in Chemistry World, “New database unlocks predictive power of radical polarity” by Rupali Dabas Highlighted in OPRD, “Some Items of Interest to Process R&D Chemists and Engineers” Org. Process Res. Dev., 2024, DOI: 10.1021/acs.oprd.4c00352 | |
| Cyclopropanation with Non-Stabilized Carbenes via Ketyl Radicals Duong T. Ngo †, Jacob J. A. Garwood †, and David A. Nagib J. Am. Chem. Soc., 2024, 146, 24009–24015 |
 Top 10 Most Read Articles in JACS, Jul/Aug 2023 Highlighted in OPRD, “Some Items of Interest to Process R&D Chemists and Engineers” Org. Process Res. Dev., 2024, DOI: 10.1021/acs.oprd.4c00352 | |
| Cyclopropanation of unactivated alkenes with non-stabilized iron carbenes Bethany M. DeMuynck, Lumin Zhang, Emma K. Ralph, and David A. Nagib Chem, 2024, 10, 1015–1027 (open access) |
 Highlighted in Chemistry World, “Iron salts catalyse the creation of carbenes for cyclopropanation” by Fernando Gomollón-Bel Highlighted in Nature Synthesis, “Cyclopropanes from iron carbenes” by Peter Seavill Highlighted in OPRD, “Some Items of Interest to Process R&D Chemists and Engineers” Org. Process Res. Dev., 2024, DOI: 10.1021/acs.oprd.4c00127 | |
 | Carbonyl cross-metathesis via deoxygenative gem-di-metal catalysis Lumin Zhang and David A. Nagib Nature Chem., 2024, 16, 107–113 (open access) |
 Highlighted in Chemistry World, “‘Transformative’ carbonyl cross-metathesis used to synthesise alkenes” by Bárbara Pinho | |
 | Carbene reactivity from alkyl and aryl aldehydes Lumin Zhang, Bethany M. DeMuynck †, Alyson N. Paneque †, Joy E. Rutherford †, and David A. Nagib Science, 2022, 377, 649–654 |
 Highlighted in Science, “Safe, selective, and scalable carbenes” by West and Rousseaux Highlighted in Chemistry World, “Carbenes, but without the explosives” by Kira Welter Highlighted in OSU News, “An easier and safer way to synthesize medicines” by Tatyana Woodall Highlighted in OPRD, “Some Items of Interest to Process R&D Chemists and Engineers” Org. Process Res. Dev., 2022, 26, 2789 | |
| γ C–H Functionalization of Amines via Triple H-Atom Transfer of a Vinyl Sulfonyl Radical Chaperone James H. Herbort †, Taylor N. Bednar †, Andrew D. Chen, T. V. RajanBabu, and David A. Nagib J. Am. Chem. Soc., 2022, 144, 13366–13373 |
 Top 10 Most Read Articles in JACS, Jul/Aug 2022 | |
 | Radical Aza-Heck Cyclization of Imidates via Energy Transfer, Electron Transfer, and Cobalt Catalysis Allen F. Prusinowski, Henry C. Sise, Taylor N. Bednar, and David A. Nagib ACS Catal., 2022, 12, 4327−4332 |
 Top 5 Most Read Articles in ACS Catalysis, Apr 2022 | |
| Aza-heterocycles via copper-catalyzed, remote C–H desaturation of amines Leah M. Stateman †, Ross M. Dare †, Alyson N. Paneque, and David A. Nagib Chem, 2022, 8, 210–224 (open access) |
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| Cross-Selective Aza-Pinacol Coupling via Atom Transfer Catalysis Sean M. Rafferty †, Joy E. Rutherford †, Lumin Zhang, Lu Wang, and David A. Nagib J. Am. Chem. Soc., 2021, 143, 5622–5628 |
 Top 5 Most Read Articles in JACS, Apr/May 2021 Highlighted in OPRD, “Some Items of Interest to Process R&D Chemists and Engineers” Org. Process Res. Dev., 2021, 25, 1701 | |
| Regioselective Radical Amino-Functionalizations of Allyl Alcohols via Dual Catalytic Cross-Coupling Zuxiao Zhang, Duong T. Ngo, and David A. Nagib ACS Catal., 2021, 11, 3473−3477 |
 Top 5 Most Read Articles in ACS Catalysis, Mar/Apr 2021 | |
| Enantioselective Radical C–H Amination for the Synthesis of β-Amino Alcohols Kohki M. Nakafuku †, Zuxiao Zhang †, Ethan A. Wappes †, Leah M. Stateman, Andrew D. Chen, and David A. Nagib Nature Chem., 2020, 12, 697–704 (open access) |
 Highlighted in OSU News, “Turning alcohol into key ingredients for new medicines” by Laura Arenschield Featured on Ohio 24/7 Now, “Alcohol & Amino Acids” by Myles Harris Highlighted in Synfacts, “Synthesis of β-Amino Alcohols…” Synfacts, 2020, 16, 1057 Behind the Paper in Nature Chemistry Communities | |
| Vicinal, Double C–H Functionalization of Alcohols via an Imidate Radical-Polar Crossover Cascade Allen F. Prusinowski, Raymond K. Twumasi, Ethan A. Wappes, and David A. Nagib J. Am. Chem. Soc., 2020, 142, 5429−5438 |
 Most Read Article in JACS, Mar/Apr 2020 Highlighted in C&E News, “Adding two functional groups to an aliphatic alcohol in one shot” by Fernando Gomollón-Bel, C&E News, 2020, 98 (12), 7 Highlighted in ChemistryViews, “Double Functionalization of Alcohols” Mar 2020 Highlighted in Organic Chemistry Portal, Oct 2020 | |
 | Radical Cascade Synthesis of Azoles via Tandem Hydrogen Atom Transfer Andrew D. Chen †, James H. Herbort †, Ethan A. Wappes, Kohki M. Nakafuku, Darsheed N. Mustafa, and David A. Nagib Chem. Sci., 2020, 11, 2479−2486 |
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| Chiral Piperidines from Acyclic Amines via Enantioselective, Radical-Mediated δ C–H Cyanation Zuxiao Zhang, Xin Zhang, and David A. Nagib Chem, 2019, 5, 3127−3134 (Open Access Pre-Print) |
 Highlighted in Chem, “Copper Interrupts N-Radical Reactivity and Enables Access to Enantiopure Piperidines” by McMillan and Leonori, Chem, 2019, 5, 3008−2010 Highlighted in OSU News, “A simpler way to make some medicines” by Laura Arenschield Featured as cover art, Dec 2019 issue of Chem | |
 | Development of an Imine Chaperone for Selective C–H Functionalization of Alcohols via Radical Relay Kohki M. Nakafuku †, Raymond K. Twumasi †, Avassaya Vanitcha †, Ethan A. Wappes, Kayambu Namitharan, Mathieu Bekkaye, and David A. Nagib J. Org. Chem., 2019, 84, 13065−13072 |
 Featured in Special Issue on C-H Bond Functionalization Most Read Article in J. Org. Chem., Sept/Oct 2019 Top 10 Most Read Article of the Year, JOC 2019 Awarded Outstanding Article of the Year, JOC 2020 | |
 | Multi-component Heteroarene Couplings via Polarity-reversed Radical Cascades Jeremy M. Lear †, J. Quentin Buquoi †, Xin Gu, Kui Pan, Darsheed N. Mustafa, and David A. Nagib Chem. Commun., 2019, 55, 8820−8823 |
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| Heteroarene Phosphinylalkylation via a Catalytic, Polarity-Reversing Radical Cascade J. Quentin Buquoi †, Jeremy M. Lear †, Xin Gu, and David A. Nagib ACS Catal., 2019, 9, 5330−5335 |
 Most Read Article in ACS Catalysis, May/Jun 2019 Top 20 Most Read Articles of the year, ACS Catalysis, 2019 | |
| Catalytic β C–H amination via an imidate radical relay Leah M. Stateman, Ethan A. Wappes, Kohki M. Nakafuku, Kara M. Edwards, and David A. Nagib Chem. Sci., 2019, 10, 2693−2699 |
 Highlighted in Chem. Sci. “Editor’s Choice” Collection, 2019 | |
 | Site-Selective C–H Functionalization of (Hetero)Arenes via Transient, Non-symmetric Iodanes Stacy C. Fosu †, Chido M. Hambira †, Andrew D. Chen, James R. Fuchs, and David A. Nagib Chem, 2019, 5, 417−428 (Open Access) |
 Highlighted in Chem, “More Than Just Acetates: PhI(OAc)2 Enables C–H Halogenation of Arenes” by Wengryniuk, Chem, 2019, 5, 254–262 Highlighted in Chem, “150th Anniversary of the Periodic Table: Breakthrough Research on Halogens” | |
| δ C−H (Hetero)Arylation via Cu-Catalyzed Radical Relay Zuxiao Zhang, Leah M. Stateman, and David A. Nagib Chem. Sci., 2019, 10, 1207−1211 |
 Highlighted in Synfacts, “Copper-Catalyzed Remote Arylation” Synfacts, 2019, 15, 171 Highlighted in Organic Chemistry Portal, Oct 2019 | |
 | Ketyl radical reactivity via atom transfer catalysis Lu Wang, Jeremy M. Lear, Sean M. Rafferty, Stacy C. Fosu and David A. Nagib Science, 2018, 362, 225−229 (open access) |
 Highlighted in Science, “Easy access to elusive radical reactions” by Blackburn and Roizen, Science, 2018, 362, 157−158 Highlighted in C&E News, “Masked aldehyde makes mild radical reaction possible” by Tien Nguyen, C&E News, 2018, 96 (42), 7 Highlighted in OSU News, “A new way to create molecules for drug development” by Jeff Grabmeier Highlighted in OPRD, “Some Items of Interest to Process R&D Chemists and Engineers” Org. Process Res. Dev., 2018, 22, 1687 Highlighted in Synfacts, “Iodine Atom Transfer Catalysis via Ketyl Radicals” Synfacts, 2019, 15, 63 > 100 citations | |
| Catalytic Alkene Difunctionalization via Imidate Radicals Kohki M. Nakafuku †, Stacy C. Fosu †, and David A. Nagib J. Am. Chem. Soc., 2018, 140, 11202−11205 |
 One of the “Most Read” articles in JACS, Aug-Oct 2018. Highlighted in OPRD, Oct 2018. “Some Items of Interest to Process R&D Chemists and Engineers” Org. Process Res. Dev., 2018, 22, 1335 | |
| β C–H di-halogenation via iterative hydrogen atom transfer Ethan A. Wappes †, Avassaya Vanitcha †, and David A. Nagib Chem. Sci., 2018, 9, 4500–4504 |
 Highlighted in Organic Chemistry Portal, Nov 2018 | |
| Directed β C–H Amination of Alcohols via Radical Relay Chaperones Ethan A. Wappes †, Kohki M. Nakafuku †, and David A. Nagib J. Am. Chem. Soc., 2017, 139, 10204–10207 |
 One of the “Most Read” articles in JACS, Aug 2017 Highlighted in OPRD, Sept 2017. “Some Items of Interest to Process R&D Chemists and Engineers” Org. Process Res. Dev., 2017, 21, 1196 Highlighted in Synform, Nov 2017 Highlighted (twice) in Organic Chemistry Portal, May 2018 and Sept 2018 Highlighted in ACS Select “JACS Young Investigators” virtual issue, Aug 2018 Highlighted in OPRD, Dec 2018. “Green Chemistry Articles of Interest to the Pharmaceutical Industry” Org. Process Res. Dev. 2018, 22, 1699 | |
 | Triiodide-Mediated δ-Amination of Secondary C-H Bonds Ethan A. Wappes, Stacy C. Fosu, Trevor C. Chopko, and David A. Nagib Angew. Chem. Int. Ed., 2016, 55, 9974–9978 |
 Highlighted in Synform, featured as cover article, Nov 2016 Highlighted in Organic Chemistry Portal, Sept 2017 | |
Reviews
 | Remote C–H Functionalization via Selective Hydrogen Atom Transfer Leah M. Stateman, Kohki M. Nakafuku, and David A. Nagib Synthesis, 2018, 50, 1569–1586 |
 An essential guide to selective C-H functionalization by radicals (for experts and beginners alike) | |
 | (Z)-N-Phenoxybenzimidoyl Chloride Ross M. Dare, and David A. Nagib Encyclopedia of Reagents for Organic Synthesis (e-EROS), 2022, DOI: 10.1002/047084289X.rn02431 |
 Explores the many uses of our imidate radical chaperone | |
Perspectives & Highlights
Radical arenes
Taylor N. Bender and David A. Nagib
Nature Chem., 2023, 15, 3–4
Asymmetric Catalysis in Radical Chemistry
David A. Nagib
Chem. Rev., 2022, 122, 15989–15992
Nitrogen gets radical
David A. Nagib
Nature Chem., 2019, 11, 396–398
Radical Conversion of Acids to Alkenes via Dual Catalysis
Allen F. Prusinowski and David A. Nagib
Trends in Chemistry, 2019, 1, 452-453
Catalytic Desymmetrization by C-H Functionalization as a Solution to the Chiral Methyl Problem
David A. Nagib
Angew. Chem. Int. Ed., 2017, 56, 7354–7356
Catalytic, Asymmetric Alkylation via Excited-State Iminium Ions
David A. Nagib
Chem, 2017, 2, 616–618
Pre-OSU
| Seven Post-Synthetic Covalent Reactions in Tandem Leading to Enzyme-Like Complexity within Metal-Organic Framework Crystals Alejandro M. Fracaroli, Peter Siman, David A. Nagib, Mitsuharu Suzuki, Hiroyasu Furukawa, F. Dean Toste, and Omar M. Yaghi J. Am. Chem. Soc., 2016, 138, 8352–8355 |
 Highlighted in Nature Nanotechnology, “Enzyme pretenders” by Bryden Le Bailly, Aug 2016. | |
 | Trifluoromethylation of Arenes and Heteroarenes by Means of Photoredox Catalysis David A. Nagib & David W. C. MacMillan Nature, 2011, 480, 224–228 |
 Awarded highest ranking of “Exceptional” by the Faculty of 1000 | |
 | Photoredox Catalysis: A Mild, Operationally Simple Approach to the Synthesis of α-Trifluoromethyl Carbonyl Compounds Phong V. Pham, David A. Nagib, David W. C. MacMillan Angew. Chem. Int. Ed., 2011, 50, 6119–6122 |
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| Enantioselective α-Trifluoromethylation of Aldehydes via Photoredox Organocatalysis David A. Nagib, Mark E. Scott, David W. C. MacMillan J. Am. Chem. Soc., 2009, 131, 10875–10877 |
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