NIGMS has funded our project R01 GM122432: PROTEIN DYNAMICS IN SITE-SPECIFIC DNA RECOMBINATION. The work will fill critical gaps in our understanding of the mechanisms of site specific DNA recombination as exemplified by Cre, a commonly used genetic engineering tool. The studies will provide new insights that could facilitate the design of recombinase variants with defined DNA sequence specificity and improved efficiency, and may suggest new avenues for controlling its activity.
New NIH R01: Protein Dynamics in Site-Specific DNA Recombination