New Paper: Mechanistic models fit to variable temperature calorimetric data provide insights into cooperativity

Elihu C. Ihms, Ian R. Kleckner, Paul Gollnick, Mark P. Foster, “Mechanistic models fit to variable temperature calorimetric data provide insights into cooperativity” Biophysical Journal 112 ( 7) 2017,  1328–1338 https://authors.elsevier.com/a/1UsgL_9FM4eH5

We use a nearest-neighbor formalism to generate a simplified binding polynomial for the 2048 configurations of TRAP + 0-11 Trp ligands, and show that temperature dependence of the ITC data provides sufficient data to constrain parameter space and define microscopic binding and interaction thermodynamics.