Previous Publications

Years 2011-2012

109. Kunys AR; Lian W; Pei D. Specificity profiling of protein-binding domains using one-bead-one-compound Peptide libraries. Curr. Protoc. Chem Biol. 2012 Dec 1;4(4):331-55.

108. Dewan V, Liu T, Chen KM, Qian Z, Xiao Y, Kleiman L, Mahasenan KV, Li C, Matsuo H, Pei D, Musier-Forsyth K. Cyclic Peptide Inhibitors of HIV-1 Capsid-Human Lysyl-tRNA Synthetase Interaction. ACS Chem Biol. ACS Chem. Biol. 2012 Apr 20;7(4):761-9

107. Malladi VL, Sobczak AJ, Meyer TM, Pei D, Wnuk SF. Inhibition of LuxS by S-ribosylhomocysteine analogues containing a [4-aza]ribose ring. Bioorg Med Chem. 2011 Sep 15;19(18):5507-19.

106. Liu, Tao; Qian, Ziqing; Xiao, Qing; Pei, Dehua. High-Throughput Screening of One-Bead-One-Compound Libraries: Identification of Cyclic Peptidyl Inhibitors against Calcineurin/NFAT Interaction. ACS Combinatorial Science  (2011), 13(5), 537-546.

105. Xianghong Wu, Lisheng Wang, Yaohua Han, Nicholas Regan, Pui-Kai Li, Miguel A. Villalona, Xiche Hu, Roger Briesewitz, and Dehua Pei. Creating Diverse Target-Binding Surfaces on FKBP12: Synthesis and
Evaluation of a Rapamycin Analogue Library. ACS Comb. Sci., 2011, 13 (5), pp 486–495

104. Zhang, Yanyan; Zhang Jinjin; Yuan, Chunhua; Hard, Ryan L.; Park, In-Hee; Li, Chenlong; Bell, Charles; Pei, Dehua. Simultaneous Binding of Two Peptidyl Ligands by a Src Homology 2 Domain. Biochemistry (2011), 50(35), 7637-7646.,

103. Ren, Lige; Chen, Xianwen; Luechapanichkul, Rinrada; Selner, Nicholas G.; Meyer, Tiffany M.; Wavreille, Anne-Sophie; Chan, Richard; Iorio, Caterina; Zhou, Xiang; Neel, Benjamin G.; et al. Substrate Specificity of Protein Tyrosine Phosphatases 1B, RPTPα, SHP- 1, and SHP- 2. Biochemistry, 2011, 50 (12), pp 2339–2356

102. Shepherd, Tyson R.; Hard, Ryan L.; Murray, Ann M.; Pei, Dehua; Fuentes, Ernesto J. Distinct Ligand Specificity of the Tiam1 and Tiam2 PDZ Domains. Biochemistry (2011), 50(8), 1296-1308.

101. Plummer, Paul; Zhu, Jinge; Akiba, Masato; Pei, Dehua; Zhang, Qijing. Identification of a key amino acid of LuxS involved in AI- 2 production in Campylobacter jejuni. PLoS One (2011), 6(1), e15876

Years 2009-2010

100. Hard, Ryan L.; Liu, Jiangxin; Shen, Juan; Zhou, Pei; Pei, Dehua. HDAC6 and Ubp-M BUZ Domains Recognize Specific C-Terminal Sequences of Proteins. Biochemistry (2010), 49(50), 10737-10746

99. Chen, Xianwen; Ren, Lige; Kim, Soochong; Carpino, Nicholas; Daniel, James L.; Kunapuli, Satya P.; Tsygankov, Alexander Y.; Pei, Dehua. Determination of the Substrate Specificity of Protein-tyrosine Phosphatase TULA-2 and Identification of Syk as a TULA-2 Substrate. Journal of Biological Chemistry (2010), 285(41), 31268-31276

98. Xiao, Qing; Zhang, Feiran; Nacev, Benjamin A.; Liu, Jun O.; Pei, Dehua. Protein N-Terminal Processing: Substrate Specificity of Escherichia coli and Human Methionine Aminopeptidases. Biochemistry (2010), 49(26), 5588-5599.

97. Liu, Tao; Liu, Yu; Kao, Hung-Ying; Pei, Dehua. Membrane Permeable Cyclic Peptidyl Inhibitors against Human Peptidylprolyl Isomerase Pin1. Journal of Medicinal Chemistry (2010), 53(6), 2494-2501.

96. Pei, Dehua. On-Bead Library Screening Made Easier. Chemistry & Biology (2010), 17(1), 3-4

95. Zhang, Yanyan; Wavreille, Anne-Sophie; Kunys, Andrew R.; Pei, Dehua. The SH2 Domains of Inositol Polyphosphate 5-Phosphatases SHIP1 and SHIP2 Have Similar Ligand Specificity but Different Binding Kinetics. Biochemistry (2009), 48(46), 11075-11083.

94. Wnuk, Stanislaw F.; Robert, Jenay; Sobczak, Adam J.; Meyers, Brandon P.; Malladi, Venkata L. A.; Zhu, Jinge; Gopishetty, Bhaskar; Pei, Dehua. Inhibition of S-ribosylhomocysteinase (LuxS) by substrate analogues modified at the ribosyl C-3 position. Bioorganic & Medicinal Chemistry (2009), 17(18), 6699-6706.

93. Ekici, Ozlem Dogan; Zhu, Jinge; Wah Chung, Ivy Yeuk; Paetzel, Mark; Dalbey, Ross E.; Pei, Dehua. Profiling the Substrate Specificity of Viral Protease VP4 by a FRET-Based Peptide Library Approach. Biochemistry (2009), 48(24), 5753-5759.a

92. Chen, Xianwen; Tan, Pauline H.; Zhang, Yanyan; Pei, Dehua. On-Bead Screening of Combinatorial Libraries: Reduction of Nonspecific Binding by Decreasing Surface Ligand Density. Journal of Combinatorial Chemistry (2009), 11(4), 604-611.

91. Liu, Tao; Joo, Sang Hoon; Voorhees, Jeffrey L.; Brooks, Charles L.; Pei, Dehua. Synthesis and screening of a cyclic peptide library: Discovery of small-molecule ligands against human prolactin receptor. Bioorganic & Medicinal Chemistry (2009), 17(3), 1026-1033.

90. Thakkar, Amit; Cohen, Allison S.; Connolly, Michael D.; Zuckermann, Ronald N.; Pei, Dehua. High-Throughput Sequencing of Peptoids and Peptide-Peptoid Hybrids by Partial Edman Degradation and Mass Spectrometry. Journal of Combinatorial Chemistry (2009), 11(2), 294-302.

89. Gopishetty, Bhaskar; Zhu, Jinge; Rajan, Rakhi; Sobczak, Adam J.; Wnuk, Stanislaw F.; Bell, Charles E.; Pei, Dehua. Probing the Catalytic Mechanism of S-Ribosylhomocysteinase (LuxS) with Catalytic Intermediates and Substrate Analogues. Journal of the American Chemical Society (2009), 131(3), 1243-1250.

Years 2007-2008

88. Gopishetty, Bhaskar; Ren, Lige, Waller, Tiffany M.; Wavreille, Anne-Sophie; Lopez, Miguel; Thakkar, Amit; Zhu, Jinge; Pei, Dehua. Synthesis of 3,5-Difluorotyrosine-Containing Peptides: Application in Substrate Profiling of Protein Tyrosine Phosphatases. Organic Letters (2008), 10(20), 4605-4608.

87. Shen, Gang; Zhu, Jinge; Simpson, Anthony M.; Pei, Dehua. Design and synthesis of macrocyclic peptidyl hydroxamates as peptide deformylase inhibitors. Bioorganic & Medicinal Chemistry Letters (2008), 18(10), 3060-3063.

86. Wnuk, Stanislaw F.; Lalama, Jennifer; Garmendia, Craig A.; Robert, Jenay; Zhu, Jinge; Pei, Dehua. S-Ribosylhomocysteine analogues with the carbon-5 and sulfur atoms replaced by a vinyl or (fluoro)vinyl unit. Bioorganic & Medicinal Chemistry (2008), 16(9), 5090-5102.

85. Zhang, Yanyan; Zhou, Shanggen; Wavreille, Anne-Sophie; DeWille, James; Pei, Dehua. Cyclic Peptidyl Inhibitors of Grb2 and Tensin SH2 Domains Identified from Combinatorial Libraries. Journal of Combinatorial Chemistry (2008), 10(2), 247-255.

84. Nguyen, Kiet T.; Pei, Dehua. High-throughput screening of peptide deformylase inhibitors. Methods in Molecular Medicine (2008), 142 (New Antibiotic Targets), 117-130.

83. Joo, Sang Hoon; Pei, Dehua. Synthesis and Screening of Support-Bound Combinatorial Peptide Libraries with Free C-Termini: Determination of the Sequence Specificity of PDZ Domains. Biochemistry (2008), 47(9), 3061-3072.

82. Zhu, Jinge; Pei, Dehua. A LuxP-Based Fluorescent Sensor for Bacterial Autoinducer II. ACS Chemical Biology (2008), 3(2), 110-119.

81. Nguyen, Kiet T.; Wu, Jen-Chieh; Boylan, Julie A.; Gherardini, Frank C.; Pei, Dehua. Zinc is the metal cofactor of Borrelia burgdorferi peptide deformylase. Archives of Biochemistry and Biophysics (2007), 468(2), 217-225.

80. Pei, Dehua; Wavreille, Anne-Sophie. Reverse interactomics: decoding protein-protein interactions with combinatorial peptide libraries. Molecular BioSystems (2007), 3(8), 536-541.

79. Xiao, Qing; Pei, Dehua. High-Throughput Synthesis and Screening of Cyclic Peptide Antibiotics. Journal of Medicinal Chemistry (2007), 50(13), 3132-3137.

78. Wavreille, Anne-Sophie; Garaud, Mathieu; Zhang, Yanyan; Pei, Dehua. Defining SH2 domain and PTP specificity by screening combinatorial peptide libraries. Methods (Oxford, United Kingdom) (2007), 42(3), 207-219.

77. Garaud, Mathieu; Pei, Dehua. Substrate Profiling of Protein Tyrosine Phosphatase PTP1B by Screening a Combinatorial Peptide Library. Journal of the American Chemical Society (2007), 129(17), 5366-5367.

76. Rajamani, Sathish; Zhu, Jinge; Pei, Dehua; Sayre, Richard. A LuxP-FRET-Based Reporter for the Detection and Quantification of AI-2 Bacterial Quorum-Sensing Signal Compounds. Biochemistry (2007), 46(13), 3990-3997.

75. Wavreille, Anne-Sophie; Pei, Dehua. A Chemical Approach to the Identification of Tensin-Binding Proteins. ACS Chemical Biology (2007), 2(2), 109-118.

74. Ekici, Ozlem Dogan; Karla, Andrew; Paetzel, Mark; Lively, Mark O.; Pei, Dehua; Dalbey, Ross E. Altered -3 Substrate Specificity of Escherichia coli Signal Peptidase 1 Mutants as Revealed by Screening a Combinatorial Peptide Library. Journal of Biological Chemistry (2007), 282(1), 417-425.

 

Years 2005-2006

73. Sweeney, Michael C.; Wang, Xianxi; Park, Junguk; Liu, Yusen; Pei, Dehua. Determination of the Sequence Specificity of XIAP BIR Domains by Screening a Combinatorial Peptide Library. Biochemistry (2006), 45(49), 14740-14748.

72. Zhu, Jinge; Knottenbelt, Sushilla; Kirk, Martin L.; Pei, Dehua. Catalytic Mechanism of S-Ribosylhomocysteinase: Ionization State of Active-Site Residues. Biochemistry (2006), 45(40), 12195-12203.

71. Joo, Sang Hoon; Xiao, Qing; Ling, Yun; Gopishetty, Bhaskar; Pei, Dehua. High-Throughput Sequence Determination of Cyclic Peptide Library Members by Partial Edman Degradation/Mass Spectrometry. Journal of the American Chemical Society (2006), 128(39), 13000-13009.

70. Imhof, Diana; Wavreille, Anne-Sophie; May, Andreas; Zacharias, Martin; Tridandapani, Susheela; Pei, Dehua. Sequence Specificity of SHP-1 and SHP-2 Src Homology 2 Domains. Critical Roles of Residues Beyond the pY+3 Position. Journal of Biological Chemistry (2006), 281(29), 20271-20282.

69. Thakkar, Amit; Wavreille, Anne-Sophie; Pei, Dehua. Traceless Capping Agent for Peptide Sequencing by Partial Edman Degradation and Mass Spectrometry. Analytical Chemistry (2006), 78(16), 5935-5939.

68. Wang, Xianxi; Matta, Ranyia; Shen, Gang; Nelin, Leif D.; Pei, Dehua; Liu, Yusen. Mechanism of triptolide-induced apoptosis: effect on caspase activation and Bid cleavage and essentiality of the hydroxyl group of triptolide. Journal of Molecular Medicine ( Heidelberg, Germany) (2006), 84(5), 405-415.

67. Shen, Gang; Rajan, Rakhi; Zhu, Jinge; Bell, Charles E.; Pei, Dehua. Design and Synthesis of Substrate and Intermediate Analogue Inhibitors of S-Ribosylhomocysteinase. Journal of Medicinal Chemistry (2006), 49(10), 3003-3011.

66. Sweeney, Michael C.; Wavreille, Anne-Sophie; Park, Junguk; Butchar, Jonathan P.; Tridandapani, Susheela; Pei, Dehua. Decoding Protein-Protein Interactions through Combinatorial Chemistry: Sequence Specificity of SHP-1, SHP-2, and SHIP SH2 Domains. Biochemistry (2005), 44(45), 14932-14947.

65. Qin, Chuanguang; Wavreille, Anne-Sophie; Pei, Dehua. Alternative Mode of Binding to Phosphotyrosyl Peptides by Src Homology-2 Domains. Biochemistry (2005), 44(36), 12196-12202.

64. Nguyen, Kiet T.; Pei, Dehua. Purification and Characterization of Enzymes Involved in the Degradation of Chemotactic N-Formyl Peptides. Biochemistry (2005), 44(23), 8514-8522.

63. Rajan, Rakhi; Zhu, Jinge; Hu, Xubo; Pei, Dehua; Bell, Charles E. Crystal Structure of S-Ribosylhomocysteinase (LuxS) in Complex with a Catalytic 2-Ketone Intermediate. Biochemistry (2005), 44(10), 3745-3753.

Years 2003-2004

62. Zhu, J., Dhimitruka, I., and Pei, D. (2004) 5-(2-Aminoethyl)-dithio-2-nitrobenzoate as a more base-stable alternative to Ellman’s reagent. Org. Lett. 6, 3809-3812.

61. Park, J., and Pei, D. (2004) trans- b -Nitrostyrene derivatives as slow-binding inhibitors of protein tyrosine phosphatases. Biochemistry 43, 15014–15021.

60. Hu, X., Nguyen, K. T., Jiang, V. C., Lofland, D., Moser, H. E., and Pei, D. (2004) Macrocyclic inhibitors for peptide deformylase: An SAR study of the ring size. J. Med. Chem. 47, 4941–4949.

59. Zhu, J., Patel, R., and Pei, D. (2004) Catalytic mechanism of S-ribosylhomocysteinase (LuxS): Stereochemical course and kinetic isotope effect of proton transfer reactions. Biochemistry 43, 10166–10172.

58. Pei , D, and Zhu, J. (2004) Mechanism of S-ribosylhomocysteinase (LuxS). Curr. Opin. Chem. Biol. 8, 492–497.

57. Nguyen, K. T., Hu, X., and Pei , D. (2004) Slow-binding inhibition of peptide deformylase by cyclic peptidomimetics as revealed by a new spectrophotometric assay. Bioorg. Chem. 32, 178–191.

56. Robien, M. A., Nguyen, K. T., Kumar, A., Hirsch, I., Turley, S., Pei, D., and Hol, W. G. J. (2004) An Improved crystal form of Plasmodium falciparum peptide deformylase. Protein Sci. 13, 1155–1163.

55. Park, J, Fu, H., and Pei, D. (2004) Peptidyl aldehydes as slow-binding inhibitors of dual-specificity phosphatases. Bioorg. Med. Chem. Lett. 14, 685–687.

54. Xian, M., Fatima, Z., Zhang, W., Fang, J., Pei, D., Loo, J., Stevenson, T., and Wang, P. G. (2004) Identification of a -Galactosyl Epitope Mimetics through Rapid Generation and Screening of C-linked Combinatorial Glycopeptide Library. J. Comb. Chem. 6, 126–134.

53. Hu, X., Zhu, J., Srivathsan, S., and Pei, D. (2004) Peptidyl Hydroxamic Acids as Methionine Aminopeptidase Inhibitors. Bioorg. Med. Chem. Lett. 14, 77–79.

52. Zhu, J., Hu, X., Dizin, E., and Pei, D. (2003) Catalytic Mechanism of S-Ribosylhomocysteinase (LuxS): Direct Observation of Ketone Intermediates by 13C NMR Spectroscopy. J. Am. Chem. Soc. 125, 13379–13381.

51. Hu, X., Nguyen, K. T., Verlinde, C. L. M. J., Hol, W. G. J., and Pei, D. (2003) Structure-based design of a macrocyclic Inhibitor for peptide deformylase. J. Med. Chem. 46, 3771–3774.

50. Nguyen, K. T., Hu, X., Colton, C., Chakrabarti, R., Zhu, M. X., and Pei, D. (2003) Characterization of a human peptide deformylase: Implications for antibacterial drug design. Biochemistry 42, 9952–9958.

49. Sweeney, M. C., & Pei, D. (2003) An Improved Method for Rapid Sequencing of Support-Bound Peptides by Partial Edman Degradation and Mass Spectrometry. J. Comb. Chem. 5, 218–222.

48. Zhu, J., Dizin, E., Hu, X., Wavreille, A.-S., Park, J., & Pei, D. (2003) S-Ribosylhomocysteinase (LuxS) is a Mononuclear Iron Protein. Biochemistry 42, 4717–4726.

47. Park, J., Fu, H., & Pei, D. (2003) Peptidyl Aldehydes as Reversible Covalent Inhibitors of Src Homology 2 Domains. Biochemistry 42, 5159–5167.

Years 2001-2002

46. Arabaci, G., Yi, T., Fu, H., Porter, M. E., Beebe, K. D., & Pei, D. (2002) a -Bromoacetophenone Derivatives As Neutral Protein Tyrosine Phosphatase Inhibitors: Structure-Function Relationship. Bioorg. Med. Chem. Lett. 12, 3047–3050.

45. Deng, H., Callender, R., Zhu, J., Nguyen, K. T., & Pei, D. (2002) Determination of the Ionization State and Catalytic Function of Glu-133 in Peptide Deformylase by Difference FTIR Spectroscopy. Biochemistry 41, 10563–10569.

44. Fu, H., Park, J., & Pei, D. (2002) Peptidyl Aldehydes as Reversible Covalent Inhibitors of Protein Tyrosine Phosphatases. Biochemistry 41, 10700–10709.

43. Wang, P., Fu, H., Snavley, D. F., Freitas, M. A., & Pei, D. (2002) Screening Combinatorial Libraries by Mass Spectrometry. 2. Identification of Optimal Substrates of Protein Tyrosine Phosphatase SHP-1. Biochemistry 41, 6202–6210.

42. Kumar, A., Nguyen, K. T., Srivathsan, S., Ornstein, B., Turley, S., Hirsch, I., Pei, D., & Hol, W. G. J. (2002) Crystals of Peptide Deformylase from Plasmodium falciparum Reveal Critical Characteristics of the Active Site for Drug Design. Structure 10, 357–367.

41. Bracchi-Ricard, V., Nguyen, K. T., Zhou, Y., Rajagopalan, P. T. R., Chakrabarti, D., and Pei, D. (2001) Characterization of an Eukaryotic Peptide Deformylase from Plasmodium falciparum. Arch. Biochem. Biophys. 396, 162–170.

40. Wang, P., Snavley, D. F., Freitas, M. A., & Pei, D. (2001) Screening Combinatorial Libraries for Optimal Enzyme Substrates by Mass Spectrometry. Rapid Commun. Mass Spectrom., 2001, 15, 1166–1171.

39. Wang, P., Arabaci, G., & Pei, D. (2001) Rapid Sequencing of Library Derived Peptides by Partial Edman Degradation and Mass Spectrometry. J. Comb. Chem. 3, 251–254.

38. Pei, D. (2001) Peptide Deformylase: A Target for Novel Antibiotics? Emerging Therapeutic Targets 5, 23–40.

Years 1989-2000

37. Liao, H., Yuan, C., Su, M.-I., Yongkiettrakul, S., Qin, D., Li, H., Byeon, I.-J., Pei, D., & Tsai, M.-D. (2000). Structure of the FHA1 domain of yeast Rad53 and identification of binding sites for both FHA1 and its target protein Rad9. J. Mol. Biol. 304, 941–951.

36. Wang, P., Byeon, I.-J. L., Liao, H., Beebe, K. D., Yongkiettrakul, S., Pei, D., and Tsai, M.-D. (2000). Structure and Specificity of the Interaction between the FHA2 Domain of Rad53 and Phosphotyrosyl Peptides. J. Mol. Biol. 302, 927–940.

35. Beebe, K. D., Wang, P., Arabaci, G., and Pei, D. (2000). Determination of the Binding Specificity of the SH2 Domains of Protein Tyrosine Phosphatase SHP-1 through the Screening of a Combinatorial Phosphotyrosyl Peptide Library. Biochemistry 39, 13251–13260.

34. Wei, Y., Yi, T., Huntington, K. M., Chaudhury, C., and Pei, D. (2000). Identification of Potent Peptide Deformylase Inhibitors from a Rationally Designed Combinatorial Library. J. Comb. Chem. 2, 650–657.
33. Wei, Y. & Pei, D. (2000). Activation of Antibacterial Prodrugs by Peptide Deformylase. Bioorg. Med. Chem. Lett. 10, 1073–1076.

32. Zhou, Y., Guo, X.-C., Yi, T., Yoshimoto, T., and Pei, D. (2000). Two Continuous Spectrophotometric Assays for Methionine Aminopeptidase. Anal. Biochem. 280, 159–165.

31. Beebe, K. D., Shin, J., Peng, J., Chaudhury, C., Khera, J., and Pei, D. (2000). Substrate Recognition through a PDZ Domain in Tail Specific Protease. Biochemistry 39, 3149–3155.

30. Huntington, K. M., Yi, T., Wei, Y., and Pei, D. (2000). Synthesis and Antibacterial Activity of Peptide Deformylase Inhibitors. Biochemistry 39, 4543–4551.

29. Rajagopalan, P. T. R., Grimme, S., and Pei, D. (2000). Characterization of Cobalt(II)-Substituted Peptide Deformylase: Function of the Metal Ion and the Catalytic Residue Glu-133. Biochemistry 39, 779–790.

28. Huntington, K. M., Bienvenue, D. L., Wei, Y., Bennet, B., Holz, R. L., and Pei, D. (1999) Slow-Binding Inhibition of the Aminopeptidase from Aeromonas proteolytica by Peptidyl Thiols: Synthesis and Spectroscopic Characterization. Biochemistry 38, 15587–15596.

27. Guo, X.-C., Rajagopalan, P. T. R., and Pei, D. (1999) A Direct Spectrophotometric Assay for Peptide Deformylase. Anal. Biochem. 273, 298–304.

26. Arabaci, G., Guo, X.-C., Beebe, K. D., Coggeshall, K. M., and Pei, D. (1999) a-Haloaceto-phenone Derivatives As Photoreversible Covalent Inhibitors of Protein Tyrosine Phosphatases. J. Am. Chem. Soc. 121, 5085–5086.

25. Hao, B., Gong, W., Rajagopalan, P. T. R., Zhou, Y., Pei, D., & Chan, M. K. (1999) Structural Basis for the Design of Antibiotics Targeting Peptide Deformylase. Biochemistry 38, 4712–4719.

24. Hu, Y.-J., Wei, Y., Zhou, Y., Rajagopalan, P. T. R., and Pei, D. (1999) Determination of Substrate Specificity for Peptide Deformylase through the Screening of a Combinatorial Peptide Library. Biochemistry 38, 643–650.

23. Hu, Y.-J., Rajagopalan, P. T. R., & Pei, D. (1998) H-Phosphonate Derivatives as Novel Peptide Deformylase Inhibitors. Bioorg. Med. Chem. Lett. 8, 2479-2482.

22. Wei, Y., Yan, Y., Pei, D., & Gong, B. (1998) Prodrug Activation by Photolysis. Bioorg. Med. Chem. Lett. 8, 2419–2422.

21. Rajagopalan, P. T. R., and Pei, D. (1998) Oxygen Mediated Inactivation of Peptide Deformylase. J. Biol. Chem. 273, 22305-22310.

20. Beebe, K. T., & Pei, D. (1998) A Continuous Fluorimetric Assay for Tail Specific Protease. Anal. Biochem. 263, 51-56.

19. Rajagopalan, P. T. R., Yu, X. C., & Pei, D. (1997) Peptide Deformylase: A New Type of Mononuclear Iron Protein. J. Am. Chem. Soc. 119, 12418-12419.

18.Chan, M. K., Gong, W., Rajagopalan, P. T. R., Hao, B., Tsai, C. M., & Pei, D. (1997) Crystal Structure of the Escherichia coli Peptide Deformylase. Biochemistry 36, 13904-13909.

17. Rajagopalan, P. T. R., Datta, A., & Pei, D. (1997) Purification, Characterization, and Inhibition of Peptide Deformylase from Escherichia coli. Biochemistry 36, 13910-13918.

16. Wei, Y. & Pei, D. (1997) Continuous Spectrophotometric Assay of Peptide Deformylase. Anal. Biochem. 250, 29-34.

15. Kharbanda, S. M., Bharti, A., Pei, D., Wang, J., Pandey, D., Ren, R., Weichselbaum, R., Walsh, C. T., & Kufe, D. (1996) The Stress Response to Ionizing Radiation Involves c-Abl-Dependent Phosphorylation of SHP-1. Proc. Natl. Acad. Sci. U.S.A. 93, 6898-6901.

14. Pei, D., Wang, J., & Walsh, C. T. (1996) Differential Functions of the Two Src Homology 2 Domains in Protein Tyrosine Phosphatase SH-PTP1. Proc. Natl. Acad. Sci. USA 93, 1141-1145.

13. Payne, G., Stolz, L. A., Pei, D., Band, H., Shoelson, S. E., Walsh, C. T. (1994) The Phosphopeptide-Binding Specificity of Src Family SH2 Domains. Chemistry & Biology 1, 99.

12. Pei, D., Lorenz, U., Klingmuller, U., Neel, B. G., & Walsh, C. T. (1994) Intramolecular Regulation of Protein Tyrosine Phosphatase SH-PTP1: A New Function for Src Homology 2 Domains. Biochemistry 33, 15483–15493.

11. Lorenz, U., Ravichandran, K. S., Pei, D., Walsh, C. T., Burakoff, S. J., & Neel, B. G. (1994) Lck-dependent Tyrosyl Phosphorylation of the Protein Tyrosine Phosphatase SH-PTP1 in Murine Cells. Mol. Cell Biol. 14, 1824.

10. Pei, D. & Schultz, P. G. (1993) Artificial Nucleases, in The Nucleases, 2nd ed.; S. Linn, S. Lloyd, R. Roberts, Eds.; Cold Spring Harbor Laboratory Press, pp317-340.

9. Pei, D., Neel, B. G., & Walsh, C. T. (1993) Overexpression, Purification, and Characterization of SHPTP1, a Src Homology 2-Containing Protein-Tyrosine-Phosphatase. Proc. Natl. Acad. Sci. USA 90, 1092–1096.

8. Williams, R. M., Glinka, T., Flanagan, M. E., Gallegos, R., Coffman, H., and Pei, D. (1992) Cannizzaro-Based O2-Dependent Cleavage of DNA by Quinocarcin. J. Am. Chem. Soc. 114, 733.

7. Pei, D., Ulrich, H. D., & Schultz, P. G. (1991) A Combinatorial Approach Towards DNA Recognition. Science 253, 1408.

6. Pei, D. & Schultz, P. G. (1991) Engineering Protein Specificity: Gene Manipulation with Semisynthetic Nucleases. J. Am. Chem. Soc. 113, 9398.

5. Pei, D., Corey, D. R., & Schultz, P. G. (1990) Site-Specific Cleavage of Duplex DNA by a Semisynthetic Nuclease via Triple-Helix Formation. Proc. Natl. Acad. Sci. USA 87, 9858.

4. Pei, D. & Schultz, P. G. (1990) Site-Specific Cleavage of Duplex DNA with a l Repressor-Staphylococcal Nuclease Hybrid. J. Am. Chem. Soc. 112, 4579.

3. Corey, D. R., Pei, D., & Schultz, P. G. (1989) Sequence-Selective Hydrolysis of Duplex DNA by an Oligonucleotide-Directed Nuclease. J. Am. Chem. Soc. 111, 8253.

2. Corey, D. R., Pei, D., & Schultz, P. G. (1989) Generation of a Catalytic Sequence-Specific Hybrid DNase. Biochemistry 28, 8277.

1. Wu, D., Pei, D., & Qu, S. (1989) Activity Coefficients and Heat Capacity of Several Synthetic Porphyrin Derivatives. Chemical Journal of Chinese Universities 10, 267.